pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-1015Research ArticleОБЗОРЫREVIEWSРоль матриксных металлопротеиназ в формировании морфофункционального дисбаланса воздухоносных путей при хронической обструктивной болезни легкихRole of matrix metalloproteinases in forming morphofunctional imbalance of airways in case of chronic obstructive lung diseaseНевзороваВ. А.NevzorovaV. A.nevzorova@inbox.ruТипикТ. В.TilikT. V.noemail@neicon.ruГилифановЕ. А.GilifanovE. A.noemail@neicon.ruПанченкоЕ. А.PanchenkoE. A.noemail@neicon.ruВахрушеваС. Е.VakhrushevaS. E.noemail@neicon.ruТипикВ. В.TilikV. V.noemail@neicon.ruВладивостокский государственный медицинский университетРоссияVladivostok State Medical UniversityRussian Federation20112806201102913Copyright © Невзорова В.А., Типик Т.В., Гилифанов Е.А., Панченко Е.А., Вахрушева С.Е., Типик В.В., 20112011Невзорова В.А., Типик Т.В., Гилифанов Е.А., Панченко Е.А., Вахрушева С.Е., Типик В.В.Nevzorova V.A., Tilik T.V., Gilifanov E.A., Panchenko E.A., Vakhrusheva S.E., Tilik V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/1015

Хроническая обструктивная болезнь легких (ХОБЛ) рассматривается в качестве никотинассоциированного заболевания, в патогенезе которого ведущее значение имеет дисбаланс в системе «протеолиз-антипротеолиз». Матриксные металло-протеиназы являются не только независимыми факторами возникновения ХОБЛ, но и играют важную роль в воспалении дыхательных путей. В обзоре с позиции современного представления о патогенезе ХОБЛ рассмотрена роль различных представителей класса матриксных металлопротеиназ. Обобщены данные как о самостоятельном влиянии активности этих ферментов на легочную ткань, так и о их важной роли в проградиентном течении воспалительной реакции в дыхательных путях.

The authors deem the chronic obstructive lung disease to be nicotine-associated disease that mostly results from the imbalance in the ‘proteolysis-antiproteolysis’ system. The matrix metalloproteinases are independent factors that play an important role in forming respiratory ways inflammation. From the present-day standpoint of the pathogenesis of chronic obstructive lung disease, the authors consider the role of various representatives of the matrix metalloproteinases’ class and summarise the current data about the independent action of these enzymes on the pulmonary tissue, and their important function in the progradient course of the inflammatory response in the respiratory ways.

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The authors declare that there are no conflicts of interest present.