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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1066</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРГАНИЗАЦИЯ ЗДРАВООХРАНЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PUBLIC HEALTH ORGANIZATION</subject></subj-group></article-categories><title-group><article-title>Клинические факторы прогноза при меланоме кожи</article-title><trans-title-group xml:lang="en"><trans-title>Clinical prognostic factors in case of skin melanoma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марочко</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Marochko</surname><given-names>A. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боровская</surname><given-names>Т. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Borovskaya</surname><given-names>T. F.</given-names></name></name-alternatives><email xlink:type="simple">bota-nya@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соболева</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Soboleva</surname><given-names>Yu. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Хабаровский филиал Российского онкологического научного центра им. Н.Н. Блохина РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Khabarovsk Branch of the Russian Oncological Scientific Centre named after N.N. Blokhin, RAMS</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Хабаровский краевой клинический центр онкологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Khabarovsk Regional Clinical Oncologic Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>03</month><year>2011</year></pub-date><volume>0</volume><issue>1</issue><fpage>86</fpage><lpage>89</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Марочко А.Ю., Боровская Т.Ф., Соболева Ю.В., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Марочко А.Ю., Боровская Т.Ф., Соболева Ю.В.</copyright-holder><copyright-holder xml:lang="en">Marochko A.Y., Borovskaya T.F., Soboleva Y.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1066">https://www.tmj-vgmu.ru/jour/article/view/1066</self-uri><abstract><p>Изучена 5- и 10- летняя выживаемость 430 больных первичной меланомой кожи, получавших лечение в онкологических учреждениях Хабаровского края в 1990-2003 гг. Наиболее неблагоприятным оказался прогноз для мужчин при локализации опухоли в области головы и шеи, а также для обоих полов при поражении кожи стоп. Зарегистрировано большое число изъязвившихся меланом. Частота изъязвления непосредственным образом связана со степенью распространения первичной опухоли и является важным универсальным фактором прогноза. Последний при изъязвлении значительно ухудшался. Частота невогенных опухолей и меланом, развившихся de novo, в Хабаровском крае была примерно одинакова. Прогноз при меланоме, возникшей de novo, более неблагоприятный. Влияние этого фактора в наибольшей степени было выражено у женщин.</p></abstract><trans-abstract xml:lang="en"><p>The authors have studied 5 and 10-year survival of 430 patients with primary skin melanoma undergone treatment in the oncological departments of the Khabarovsk Krai in 1990-2003. The most unfavourable prognosis appeared to occur for men with the tumours localized on the head and neck and both sexes in case of foot skin lesions. There was a large number of ulcerated melanoma. The ulceration rate directly correlated to the extent of primary tumour dissemination, and was an important universal prognostic factor. Given the ulceration, it considerably worsened the situation. The occurrence of de novo tumours and melanomas in the Khabarovsk Krai was approximately equal. In case of de novo melanoma, the prognosis for the disease was more unfavourable. This factor was more evident with respect to women.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>меланома кожи</kwd><kwd>прогноз</kwd><kwd>выживаемость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>skin melanoma</kwd><kwd>prognosis</kwd><kwd>survival rate</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Анисимов В.В. Меланома кожи (перспективы улучшения диагностики и лечения): дис.. д-ра мед. наук. СПб., 2000. 97 с.</mixed-citation><mixed-citation xml:lang="en">Анисимов В.В. Меланома кожи (перспективы улучшения диагностики и лечения): дис.. д-ра мед. наук. СПб., 2000. 97 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ганина К.П., Налескина Л.А. Злокачественная меланома и предшествующие изменения кожи. 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