References

pmj

Тихоокеанский медицинский журнал

Pacific Medical Journal

1609-1175

TGMU

10.17238/PmJ1609-1175.2017.1.37-41

pmj-108

Research Article

ОБЗОРЫ

REVIEWS

Биомаркеры и участники ремоделирования субхондральной кости при остеоартрозе

Biomarkers of subchondral bone remodeling in osteoarthritis

Кабалык

М. А.

Kabalyk

M. A.

maxi_maxim@mail.ru

Тихоокеанский государственный медицинский университетРоссияPacific State Medical UniversityRussian Federation

2017

28032017

013641

2017

Кабалык М.А.

Kabalyk M.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.tmj-vgmu.ru/jour/article/view/108

Остеоартроз (ОА) - наиболее распространенное и социально значимое заболевание опорно-двигательного аппарата, основной проблемой лечения которого является отсутствие диагностических и прогностических маркеров ранних стадий заболевания. Цель этого обзора - анализ данных о биомаркерах деградации субхондральной кости при ОА. Рассматриваются субфенотипические молекулы - холекальциферол и паратиреоидный гормон, а также биологические субстанции, образующиеся остеобластами на разных стадиях костной дифференцировки. Обзор литературы позволяет предположить важное диагностическое значение при ОА целого ряда биологических субстанций, среди которых наибольший интерес представляют остеокальцин, кальцитонин, продукты деградации фибриллярных белков костного и хрящевого матрикса, холекальциферол. Перспективным видится исследование диагностической значимости описанных биологических маркеров, что в значительной степени будет способствовать расширению диагностического и прогностического инструментария и поможет более подробно оценивать неоднородную популяцию больных ОА.

Osteoarthritis - the most widespread and socially significant diseases of the musculoskeletal system, the main problem is the lack of treatment which diagnostic and prognostic markers of early stages of the disease. The purpose of this review is an analysis of biomarker degradation of the subchondral bone in osteoarthritis. The article reviews subphenotypic molecules - cholecalciferol and parathyroid hormone, and biological substances produced by osteoblasts at various stages of bone differentiation. The review of the literature suggests an important diagnostic value of a variety of biological substances in osteoarthritis, among which the most interesting are osteocalcin, calcitonin, fibrillar protein degradation products of bone and cartilage matrix, cholecalciferol. It appears promising study the diagnostic value of biomarkers disclosed that a significant degree will contribute to the expansion of the diagnostic and prognostic tools, and allow more detailed assessment of a heterogeneous population of patients with osteoarthritis.

остеобластыколлагенремоделирование костисуставной хрящ

osteoblastscollagenbone remodelingarticular cartilage

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The authors declare that there are no conflicts of interest present.