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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1130</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>ИЗУЧЕНИЕ НИТРОКСИДМОДУЛИРУЮЩЕГО ДЕЙСТВИЯ ПРОМЕДОЛА ПРИ ОДНОКРАТНОМ
ПРИМЕНЕНИИ ДЛЯ ПРЕДОПЕРАЦИОННОГО ОБЕЗБОЛИВАНИЯ У ОНКОЛОГИЧЕСКИХ БОЛЬНЫХ</article-title><trans-title-group xml:lang="en"><trans-title>STUDYING NITRIC OXIDE-MODULATING EFFECT
OF PROMEDOL DURING SINGLE APPLICATION FOR
PRE-OPERATIVE ANESTHESIA OF ONCOLOGICAL
PATIENTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дюйзен</surname><given-names>И. В.</given-names></name></name-alternatives><email xlink:type="simple">duval@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ламаш</surname><given-names>Н. Е.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денеж</surname><given-names>А. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фадеева</surname><given-names>А. С.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Dyuizen</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Lamash</surname><given-names>N. E.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Denezh</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Fadeeva</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Лаборатория фармакологии Института биологии моря им. А.В. Жирмунского ДВО РАН; Владивостокский государственный медицинский университет</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Приморский краевой онкологический диспансер</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-3"><institution>Laboratory of Pharmacology of Institute of Marine Biology
named after A.V. Zhirmundsky, FEB RAS;  Vladivostok State Medical
University</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-4"><institution>Primorsky Regional Oncological Dispensary</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2010</year></pub-date><volume>0</volume><issue>2</issue><fpage>43</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дюйзен И.В., Ламаш Н.Е., Денеж А.А., Фадеева А.С., Dyuizen I.V., Lamash N.E., Denezh A.A., Fadeeva A.S., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Дюйзен И.В., Ламаш Н.Е., Денеж А.А., Фадеева А.С., Dyuizen I.V., Lamash N.E., Denezh A.A., Fadeeva A.S.</copyright-holder><copyright-holder xml:lang="en">Дюйзен И.В., Ламаш Н.Е., Денеж А.А., Фадеева А.С., Dyuizen I.V., Lamash N.E., Denezh A.A., Fadeeva A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1130">https://www.tmj-vgmu.ru/jour/article/view/1130</self-uri><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>оксид азота</kwd><kwd>боль</kwd><kwd>эндогенная аналгезия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nitric oxide</kwd><kwd>pain</kwd><kwd>endogenous analgesia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Abdel-Zaher A.O., Hamdy M.M., Aly S.A. et al. Attenuation of morphine tolerance and dependence by aminoguanidine in mice // Eur. J. Pharmacol. 2006. Vol. 1, No. 540. P. 60-66.</mixed-citation><mixed-citation xml:lang="en">Abdel-Zaher A.O., Hamdy M.M., Aly S.A. et al. Attenuation of morphine tolerance and dependence by aminoguanidine in mice // Eur. J. Pharmacol. 2006. Vol. 1, No. 540. P. 60-66.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Batista A., Macedo T., Tavares P., Ribeiro C.F. et al. Nitric oxide production and nitric oxide synthase expression in platelets from heroin abusers before and after ultrarapid detoxification //Ann. N. Y. Acad. Sci. 2002. Vol. 965. P. 479-486.</mixed-citation><mixed-citation xml:lang="en">Batista A., Macedo T., Tavares P., Ribeiro C.F. et al. Nitric oxide production and nitric oxide synthase expression in platelets from heroin abusers before and after ultrarapid detoxification //Ann. N. Y. Acad. Sci. 2002. Vol. 965. P. 479-486.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ebert B., Thorkildsen C., Andersen S. et al. Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists // Biochem. Pharmacol. 1998. Vol. 56, No. 5. P. 553-559.</mixed-citation><mixed-citation xml:lang="en">Ebert B., Thorkildsen C., Andersen S. et al. Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists // Biochem. Pharmacol. 1998. Vol. 56, No. 5. P. 553-559.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Freirel M.A.M., Guimar?es1 J.S., Leal W.G., Pereira1 A. Pain modulation by nitric oxide in the spinal cord // Frontiers in Neurosci. 2009. Vol. 3, No 2. P. 175-181.</mixed-citation><mixed-citation xml:lang="en">Freirel M.A.M., Guimar?es1 J.S., Leal W.G., Pereira1 A. Pain modulation by nitric oxide in the spinal cord // Frontiers in Neurosci. 2009. Vol. 3, No 2. P. 175-181.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hoogstraate J., Andersson L.I., Berge O.-G. et al. COX-inhibiting nitric oxide donators (CINODs) - a new paradigm in the treatment of pain and inflammation // Inflammopharmacology 2003. Vol. 11, No. 4-6. P. 423-428.</mixed-citation><mixed-citation xml:lang="en">Hoogstraate J., Andersson L.I., Berge O.-G. et al. COX-inhibiting nitric oxide donators (CINODs) - a new paradigm in the treatment of pain and inflammation // Inflammopharmacology 2003. Vol. 11, No. 4-6. P. 423-428.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kampa1 M., Hatzoglou1 A., Notas G., Niniraki M., Kouroumalis E., Castanas E. Opioids are non-competitive inhibitors of nitric oxidesynthase in T47D human breast cancer cells // Cell Death and Differentiation. 2001. Vol. 8. P. 943-952.</mixed-citation><mixed-citation xml:lang="en">Kampa1 M., Hatzoglou1 A., Notas G., Niniraki M., Kouroumalis E., Castanas E. Opioids are non-competitive inhibitors of nitric oxidesynthase in T47D human breast cancer cells // Cell Death and Differentiation. 2001. Vol. 8. P. 943-952.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Machelska H., Labuz D., Przewocki R., Przewocka B. Inhibition of Nitric Oxide Synthase Enhances Antinociception Mediated by Mu, Delta and Kappa Opioid Receptors in Acute and Prolonged Pain in the Rat Spinal Cord // Mol. Pharmacol. 1997. Vol. 282, No. 2. P. 977-984.</mixed-citation><mixed-citation xml:lang="en">Machelska H., Labuz D., Przewocki R., Przewocka B. Inhibition of Nitric Oxide Synthase Enhances Antinociception Mediated by Mu, Delta and Kappa Opioid Receptors in Acute and Prolonged Pain in the Rat Spinal Cord // Mol. Pharmacol. 1997. Vol. 282, No. 2. P. 977-984.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mastronicolaa D., Arcuric E., Aresea M. et al. Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells // Cell. Mol. Life Sci. 2004. Vol. 61, P. 2991-2997.</mixed-citation><mixed-citation xml:lang="en">Mastronicolaa D., Arcuric E., Aresea M. et al. Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells // Cell. Mol. Life Sci. 2004. Vol. 61, P. 2991-2997.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Salerno L., Sorrenti V., Di Giacomo C. et al. Progress in the development of selective nitric oxide synthase (NOS) inhibitors // Curr. Pharm. Des. 2002. Vol. 8, No. 3. P. 177-200.</mixed-citation><mixed-citation xml:lang="en">Salerno L., Sorrenti V., Di Giacomo C. et al. Progress in the development of selective nitric oxide synthase (NOS) inhibitors // Curr. Pharm. Des. 2002. Vol. 8, No. 3. P. 177-200.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Stefano G.B., Hartman A., Bilfinger T.V. et al. Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation // J. Biol. Chem. 1995. Vol. 270, No. 51. P. 30290-30293.</mixed-citation><mixed-citation xml:lang="en">Stefano G.B., Hartman A., Bilfinger T.V. et al. Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation // J. Biol. Chem. 1995. Vol. 270, No. 51. P. 30290-30293.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Watanabea C., Okudab K., Sakuradac C. et al. Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats // Brain Res. 2003. Vol. 990, P. 77- 86.</mixed-citation><mixed-citation xml:lang="en">Watanabea C., Okudab K., Sakuradac C. et al. Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats // Brain Res. 2003. Vol. 990, P. 77- 86.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
