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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1143</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>ВЛИЯНИЕ ХИТОЗАНОВ С РАЗЛИЧНОЙ МОЛЕКУЛЯРНОЙ МАССОЙ НА РАЗВИТИЕ
АДЕНОКАРЦИНОМЫ ЭРЛИХА И ЭФФЕКТИВНОСТЬ ЦИКЛОФОСФАНА У МЫШЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>Effect of Chitosans of Diferent Molecular
Mas on Ehrlich Adenocarcinoma Growth
and Efficiency of Cyclophosphane in Mice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зуева</surname><given-names>Е. П.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Разина</surname><given-names>Т. Г.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амосова</surname><given-names>Е. Н.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крылова</surname><given-names>С. Г.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лопатина</surname><given-names>К. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефимова</surname><given-names>Л. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сафонова</surname><given-names>Е. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыбалкина</surname><given-names>О. Ю.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хотимченко</surname><given-names>Ю. С.</given-names></name></name-alternatives><email xlink:type="simple">yukhotimchenko@imb.dvo.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Zueva</surname><given-names>E. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Razina</surname><given-names>T. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Amosova</surname><given-names>E. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Kryilova</surname><given-names>S. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Lopatina</surname><given-names>K. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Efimova</surname><given-names>L. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Safonova</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Ryibalkina</surname><given-names>O. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Khotimchenko</surname><given-names>Yu. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>НИИ фармакологии СО РАМН</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Институт биологии моря им. А.В. Жирмунского ДВО РАН</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-3"><institution>Research Institute of Pharmacology, SB RAMS</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-4"><institution>Institute of Marine Biology named after
A.V. Zhirmundsky, FEB RAS</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2010</year></pub-date><volume>0</volume><issue>2</issue><fpage>82</fpage><lpage>84</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зуева Е.П., Разина Т.Г., Амосова Е.Н., Крылова С.Г., Лопатина К.А., Ефимова Л.А., Сафонова Е.А., Рыбалкина О.Ю., Хотимченко Ю.С., Zueva E.P., Razina T.G., Amosova E.N., Kryilova S.G., Lopatina K.A., Efimova L.A., Safonova E.A., Ryibalkina O.Y., Khotimchenko Y.S., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Зуева Е.П., Разина Т.Г., Амосова Е.Н., Крылова С.Г., Лопатина К.А., Ефимова Л.А., Сафонова Е.А., Рыбалкина О.Ю., Хотимченко Ю.С., Zueva E.P., Razina T.G., Amosova E.N., Kryilova S.G., Lopatina K.A., Efimova L.A., Safonova E.A., Ryibalkina O.Y., Khotimchenko Y.S.</copyright-holder><copyright-holder xml:lang="en">Зуева Е.П., Разина Т.Г., Амосова Е.Н., Крылова С.Г., Лопатина К.А., Ефимова Л.А., Сафонова Е.А., Рыбалкина О.Ю., Хотимченко Ю.С., Zueva E.P., Razina T.G., Amosova E.N., Kryilova S.G., Lopatina K.A., Efimova L.A., Safonova E.A., Ryibalkina O.Y., Khotimchenko Y.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1143">https://www.tmj-vgmu.ru/jour/article/view/1143</self-uri><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>хитозан</kwd><kwd>аденокарцинома Эрлиха</kwd><kwd>циклофосфан</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chitosan</kwd><kwd>Ehrlich adenocarcinoma</kwd><kwd>cyclophosphane</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Лакин Г.Ф. Биометрия. М.: Высшая школа, 1980. 293 с.</mixed-citation><mixed-citation xml:lang="en">Лакин Г.Ф. Биометрия. М.: Высшая школа, 1980. 293 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Софьина З.П., Сыркин А.Б., Голдин А., Кляйн А. Экспериментальная оценка противоопухолевых препаратов в СССР и США. М.: Медицина, 1980. 296 с.</mixed-citation><mixed-citation xml:lang="en">Софьина З.П., Сыркин А.Б., Голдин А., Кляйн А. Экспериментальная оценка противоопухолевых препаратов в СССР и США. М.: Медицина, 1980. 296 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Хотимченко Ю.С., Хасина Э.И., Ковалев В.В. и др. Эффективность пищевых некрахмальных полисахаридов при экспериментальном токсическом гепатите // Вопросы питания. 2000. Т. 69, № 1/2. С. 22-26.</mixed-citation><mixed-citation xml:lang="en">Хотимченко Ю.С., Хасина Э.И., Ковалев В.В. и др. Эффективность пищевых некрахмальных полисахаридов при экспериментальном токсическом гепатите // Вопросы питания. 2000. Т. 69, № 1/2. С. 22-26.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Baek K.S., Won E.K., Choung S.Y. Effects of chitosan on serum cytokine levels in elderly subjects // Arch. Pharm. Res. 2007. Vol. 30, N 12. P. 1550-1557.</mixed-citation><mixed-citation xml:lang="en">Baek K.S., Won E.K., Choung S.Y. Effects of chitosan on serum cytokine levels in elderly subjects // Arch. Pharm. Res. 2007. Vol. 30, N 12. P. 1550-1557.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gallaher D.D., Gallaher C.M., Mahrt G.J. et al. A glucomannan and chitosan fiber supplement decreases plasma cholesterol and increases cholesterol excretion in overweight normocholesterolemic humans // J. Am. Coll. Nutr. 2002. Vol. 21, No. 5. P. 428-433.</mixed-citation><mixed-citation xml:lang="en">Gallaher D.D., Gallaher C.M., Mahrt G.J. et al. A glucomannan and chitosan fiber supplement decreases plasma cholesterol and increases cholesterol excretion in overweight normocholesterolemic humans // J. Am. Coll. Nutr. 2002. Vol. 21, No. 5. P. 428-433.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Khotimchenko M., Sergushchenko I., Khotimchenko Y.S. The effects of low-esterified pectin on lead-induced thyroid injury in rats // Environmental Toxicology and Pharmacology. 2004. Vol. 17. P. 67-71.</mixed-citation><mixed-citation xml:lang="en">Khotimchenko M., Sergushchenko I., Khotimchenko Y.S. The effects of low-esterified pectin on lead-induced thyroid injury in rats // Environmental Toxicology and Pharmacology. 2004. Vol. 17. P. 67-71.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kimura Y., Onoyama M., Sera T., Okuda H. Antitumor activity and side effects of combined treatment with chitosan and cisplatin in sarcoma 180-bearing mice // J. Pharm. Pharmacol. 2000. Vol. 52. P. 883-890.</mixed-citation><mixed-citation xml:lang="en">Kimura Y., Onoyama M., Sera T., Okuda H. Antitumor activity and side effects of combined treatment with chitosan and cisplatin in sarcoma 180-bearing mice // J. Pharm. Pharmacol. 2000. Vol. 52. P. 883-890.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kimura Y., Sawai N., Okuda H. Antitumor activity and adverse reactions of combined treatment with chitosan and doxorubicin in tumor-bearing mice // J. Pharm. Pharmacol. 2001. Vol. 53. P. 1373-1378.</mixed-citation><mixed-citation xml:lang="en">Kimura Y., Sawai N., Okuda H. Antitumor activity and adverse reactions of combined treatment with chitosan and doxorubicin in tumor-bearing mice // J. Pharm. Pharmacol. 2001. Vol. 53. P. 1373-1378.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kimura Y., Okuda H. Prevention by chitosan of myelotoxicity, gastrointestinal toxicity and immunocompetent organic toxicity induced by 5-flurouracil without loss of antitumor activity in mice // Jpn. J. Cancer Res. 1999. Vol. 90. P. 765-774.</mixed-citation><mixed-citation xml:lang="en">Kimura Y., Okuda H. Prevention by chitosan of myelotoxicity, gastrointestinal toxicity and immunocompetent organic toxicity induced by 5-flurouracil without loss of antitumor activity in mice // Jpn. J. Cancer Res. 1999. Vol. 90. P. 765-774.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Maeda Y., Kimura Y. Antitumor effects of various low-molecular- weight chitosans are due to increased natural killer aactivity of intestinal intraepithelial lymphocytes in sarcoma 180-bearing mice // J. Nutr. 2004. Vol. 134. P. 945-950.</mixed-citation><mixed-citation xml:lang="en">Maeda Y., Kimura Y. Antitumor effects of various low-molecular- weight chitosans are due to increased natural killer aactivity of intestinal intraepithelial lymphocytes in sarcoma 180-bearing mice // J. Nutr. 2004. Vol. 134. P. 945-950.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Shen K.T., Chen M.H., Chan H.Y. et al. Inhibitory effects of chitooligosaccharides on tumor growth and metastasis // Food Chem. Toxicol. 2009. Vol. 47, No. 8. P. 1864-1871.</mixed-citation><mixed-citation xml:lang="en">Shen K.T., Chen M.H., Chan H.Y. et al. Inhibitory effects of chitooligosaccharides on tumor growth and metastasis // Food Chem. Toxicol. 2009. Vol. 47, No. 8. P. 1864-1871.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Singla A.K., Chawla M. Chitosan: some pharmaceutical and biological aspects - an update // J. Pharm. Pharmacol. 2001. Vol. 53. P. 1047-1067.</mixed-citation><mixed-citation xml:lang="en">Singla A.K., Chawla M. Chitosan: some pharmaceutical and biological aspects - an update // J. Pharm. Pharmacol. 2001. Vol. 53. P. 1047-1067.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Torzsas T.L., Kendall C.W., Sugano M. et al. The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice // Food Chem. Toxicol. 1996. Vol. 34, No. 1. P. 73-77.</mixed-citation><mixed-citation xml:lang="en">Torzsas T.L., Kendall C.W., Sugano M. et al. The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice // Food Chem. Toxicol. 1996. Vol. 34, No. 1. P. 73-77.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng I.Y., Zhu J.F. Study on antimicrobial activity of chitosan with different molecular weights // Carbohydr. Polym. 2003. Vol. 54. P. 527-530.</mixed-citation><mixed-citation xml:lang="en">Zheng I.Y., Zhu J.F. Study on antimicrobial activity of chitosan with different molecular weights // Carbohydr. Polym. 2003. Vol. 54. P. 527-530.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
