pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-1156Research ArticleСтатьиПОЛИМОРФИЗМ ГЕНОВ ГЛЮТАТИОНТРАНСФЕРАЗ ПРИ ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНИ ЛЕГКИХ, АССОЦИИРОВАННОЙ С ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦАPOLYMORPHISM OF GLUTATHIONE TRANSFERASE GENES IN CASE OF CHRONIC OBSTRUCTIVE LUNG DISEASE ASSOCIATED WITH ISCHEMIC HEART DISEASEТиликТ. В.yersinia@inboxНевзороваВ. А.gmu.nauka@mail.ruВахрушеваС. Е.noemail@neicon.ruПанченкоЕ. А.noemail@neicon.ruИсаеваМ. П.noemail@neicon.ruTilikT. V.noemail@neicon.ruNevzorovaV. A.noemail@neicon.ruVakhrushevaS. E.noemail@neicon.ruPanchenkoE. A.noemail@neicon.ruIsaevaM. P.noemail@neicon.ruВладивостокский государственный медицинский университетRussian Federationихоокеанский институт биоорганической химии ДВО РАНRussian FederationVladivostok State Medical UniversityRussian FederationPacific Institute of Bioorganic Chemistry of FEB RASRussian Federation201028032010011315Copyright © Тилик Т.В., Невзорова В.А., Вахрушева С.Е., Панченко Е.А., Исаева М.П., Tilik T.V., Nevzorova V.A., Vakhrusheva S.E., Panchenko E.A., Isaeva M.P., 20102010Тилик Т.В., Невзорова В.А., Вахрушева С.Е., Панченко Е.А., Исаева М.П., Tilik T.V., Nevzorova V.A., Vakhrusheva S.E., Panchenko E.A., Isaeva M.P.Тилик Т.В., Невзорова В.А., Вахрушева С.Е., Панченко Е.А., Исаева М.П., Tilik T.V., Nevzorova V.A., Vakhrusheva S.E., Panchenko E.A., Isaeva M.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/1156

С помощью полимеразной цепной реакции изучено распределение полиморфных вариантов генов, кодирующих глютатионтрансферазы (GSTM1 и GSTT1), у 60 пациентов с хронической обструктивной болезнью легких, ассоциированной со стабильной стенокардией, и у 30 здоровых лиц. Установлена высокая частота гомозиготной делеции этих генов у больных, причем нулевой генотип GSTT1 был достоверно связан с тяжестью патологии легких. При ассоциированном делеционном генотипе GSTM1 и GSTT1 зарегистрировано повышение относительного риска возникновения сочетанной патологии легких и сердца. Выявление молекулярно-генетических маркеров позволит использовать их для выделения групп риска и проведения адекватной профилактики хронической обструктивной болезни легких и ишемической болезни сердца.

Applying polymerase chain reaction, the authors have studied distribution of polymorphous variants of genes responsible for coding glutathione transferases (GSTM1 и GSTT1) in 60 patients with chronic obstructive lung disease associated with stable angina and 30 healthy men and detected high frequency of homozygous deletions of these genes. The zero genotype GSTT1 is reliably indicative of the severity of lung pathology. The associated deletion genotype GSTM1 and GSTT1 is characterized by increasing relative risk of a combined pathology of heart and lungs. Detection of molecular genetic markers will make it possible to apply them for identifying risk groups and implementing prevention of chronic obstructive lung disease and ischemic heart disease.

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The authors declare that there are no conflicts of interest present.