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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1194</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>ОБОСНОВАНИЕ ИММУНОТРОПНОЙ ТЕРАПИИ ПРИ ВНУТРИУТРОБНОЙ ПНЕВМОНИИ У НОВОРОЖДЕННЫХ ДЕТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>JUSTIFICATION FOR IMMUNOTROPIC THERAPY DURING CONGENITAL PNEUMONIA DIAGNOSED IN NEWBORN CHILDREN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бениова</surname><given-names>С. Н.</given-names></name></name-alternatives><email xlink:type="simple">snbeniova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полякова</surname><given-names>М. С.</given-names></name></name-alternatives><email xlink:type="simple">mshegeda@rambler.ru &lt;mailto:mshegeda@rambler.ru&gt;</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шегеда</surname><given-names>М. Г.</given-names></name></name-alternatives><email xlink:type="simple">mshegeda@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блохина</surname><given-names>Н. П.</given-names></name></name-alternatives><email xlink:type="simple">mshegeda@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Королев</surname><given-names>А. Г.</given-names></name></name-alternatives><email xlink:type="simple">mshegeda@rambler.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдуллаева</surname><given-names>Е. С.</given-names></name></name-alternatives><email xlink:type="simple">mshegeda@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Beniova</surname><given-names>S. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Polyakova</surname><given-names>M. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Shegeda</surname><given-names>M. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Blokhina</surname><given-names>N. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Korolev</surname><given-names>A. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Abdullaeva</surname><given-names>E. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Владивостокский государственный медицинский университет</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Городской клинический родильный дом</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>Детская городская клиническая больница</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-4"><institution>Vladivostok State Medical University</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-5"><institution>Municipal Clinical Maternity Hospital</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-6"><institution>Children's Municipal Clinical Hospital</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2009</year></pub-date><volume>0</volume><issue>4</issue><fpage>28</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бениова С.Н., Полякова М.С., Шегеда М.Г., Блохина Н.П., Королев А.Г., Абдуллаева Е.С., Beniova S.N., Polyakova M.S., Shegeda M.G., Blokhina N.P., Korolev A.G., Abdullaeva E.S., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Бениова С.Н., Полякова М.С., Шегеда М.Г., Блохина Н.П., Королев А.Г., Абдуллаева Е.С., Beniova S.N., Polyakova M.S., Shegeda M.G., Blokhina N.P., Korolev A.G., Abdullaeva E.S.</copyright-holder><copyright-holder xml:lang="en">Бениова С.Н., Полякова М.С., Шегеда М.Г., Блохина Н.П., Королев А.Г., Абдуллаева Е.С., Beniova S.N., Polyakova M.S., Shegeda M.G., Blokhina N.P., Korolev A.G., Abdullaeva E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1194">https://www.tmj-vgmu.ru/jour/article/view/1194</self-uri><trans-abstract xml:lang="en"><p>The paper describes results of studies of system of cytokines and a1-acid glycoprotein carried out for 60 new-born children suffered from congenital pneumonia, within the first 3 days of their lives. It has been revealed that imbalance of immunologic mechanisms of new-born children having congenital pneumonia is accompanied by decrease in neutrophil inflammatory responses, manifests in low level of interleukin-8 and ineffectiveness of protective and adaptive cell functions. Applying of Viferon-1 as a part of complex therapy allowed the survival rate for new-born children having severe manifestations of disease to increase as well as the intensive care to be optimised, the periods of treatment to shorten and the detected immunologic imbalance to be resolved in due time.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>новорожденные</kwd><kwd>пневмония</kwd><kwd>цитокины</kwd><kwd>виферон</kwd></kwd-group><kwd-group xml:lang="en"><kwd>new-born children</kwd><kwd>pneumonia</kwd><kwd>cytokines</kwd><kwd>Viferon</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Апциаури Н.Е., Банковская Л.В., Шуйкина Э.Е. и др. Генерация активных форм кислорода макрофагами мышей: влияние генотипа, иммуноцитокинов и инфицирования // Журнал микробиологии, эпидемиологии и иммунологии. 1994. № 2. 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