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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1200</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>ЗНАЧЕНИЕ ЦИТОКИНОВОГО СТАТУСА В РАННЕЙ ДИАГНОСТИКЕ ТУБЕРКУЛЕЗА ПРИ ВИЧ-ИНФЕКЦИИ</article-title><trans-title-group xml:lang="en"><trans-title>SIGNIFICANCE OF CYTOKINE STATUS IN EARLY DIAGNOSTICS OF TUBERCULOSIS ASSOCIATED WITH
HIV-INFECTION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маркелова</surname><given-names>Е. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сотниченко</surname><given-names>С. А.</given-names></name></name-alternatives><email xlink:type="simple">kcspid@mail.ru &lt;mailto:kcspid@mail.ru&gt;</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скляр</surname><given-names>Л. Ф.</given-names></name></name-alternatives><email xlink:type="simple">l_f_skljar@bk.ru &lt;mailto:l_f_skljar@bk.ru&gt;</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Markelova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Sotnichenko</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Sklyar</surname><given-names>L. F.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Владивостокский государственный медицинский университет</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Краевой клинический центр по профилактике и борьбе со СПИД и инфекционными заболеваниями</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-3"><institution>Vladivostok State Medical University</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-4"><institution>Regional Clinical Centre of Prevention and Fight against AIDS</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2009</year></pub-date><volume>0</volume><issue>4</issue><fpage>44</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Маркелова Е.В., Сотниченко С.А., Скляр Л.Ф., Markelova E.V., Sotnichenko S.A., Sklyar L.F., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Маркелова Е.В., Сотниченко С.А., Скляр Л.Ф., Markelova E.V., Sotnichenko S.A., Sklyar L.F.</copyright-holder><copyright-holder xml:lang="en">Маркелова Е.В., Сотниченко С.А., Скляр Л.Ф., Markelova E.V., Sotnichenko S.A., Sklyar L.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1200">https://www.tmj-vgmu.ru/jour/article/view/1200</self-uri><trans-abstract xml:lang="en"><p>HIV-positive patients and patients having HIV-infection associated with tuberculosis. The authors have studied dependency of detection probability for tuberculosis diagnosed in HIV-positive patients from initial levels of immunological profile at various stages of disease using stratification analysis. They also have performed logistic regression analysis with backward selection of predictors and detecting of tuberculosis contagion as dependent variable. Tuberculosis risk was dependent to a considerable extent on HIV RNA level, number of lymphocytes and length of tuberculosis preventive treatment. They have suggested a diagnostic search algorithm for early detection of tuberculosis in HIV-positive patients, which implies monitoring of ummunological markers (tumour-a necrosis factor, interleukin-10 and soluble receptor of interleukin-6) and their detection in certain intervals.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ВИЧ-инфекция</kwd><kwd>туберкулез</kwd><kwd>цитокины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>HIV-infection</kwd><kwd>tuberculosis</kwd><kwd>cytokines</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Карачунский М.А. Туберкулез при ВИЧ-инфекции // Проблемы туберкулеза. 2000. № 1. С. 47-52. Клинические рекомендации. ВИЧ-инфекция и СПИД / под ред. В.В. Покровского. М.: ГЭОТАР-Медиа, 2006. 128 с.</mixed-citation><mixed-citation xml:lang="en">Карачунский М.А. Туберкулез при ВИЧ-инфекции // Проблемы туберкулеза. 2000. № 1. С. 47-52. 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