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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1472</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>Продленная эпидуральная инфузия в предоперационной подготовке больных с критической ишемией нижних конечностей на фоне хронического болевого синдрома</article-title><trans-title-group xml:lang="en"><trans-title>Prolonged epidural infusion in preoperative treatment of patients with a critical ischemia of the legs in case of the chronic pain</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новиков</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikov</surname><given-names>A. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голуб</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Golub</surname><given-names>I. E.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Майстровский</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Maistrovskiy</surname><given-names>K. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Приморская краевая клиническая больница № 1 (г. Владивосток)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Primorsky Regional Hospital No. 1 (Vladivostok)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Иркутский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Irkutsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>28</day><month>03</month><year>2008</year></pub-date><volume>0</volume><issue>1</issue><fpage>46</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Новиков А.Ю., Голуб И.Е., Майстровский К.В., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Новиков А.Ю., Голуб И.Е., Майстровский К.В.</copyright-holder><copyright-holder xml:lang="en">Novikov A.Y., Golub I.E., Maistrovskiy K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1472">https://www.tmj-vgmu.ru/jour/article/view/1472</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>The analysis of treatment of a pain syndrome in a complex of preoperative treatment at 60 patients with a critical ischemia of the legs is done. We used the epidural anesthesia of the Ropivacain (control), epidural anesthesia and intramuscular Ketoprophen (1st group), and also epidural anesthesia, Ketoprophen and analgetic doze of the Kethamine (2nd group). It is shown, that multimodal and preventive method of preoperative treatment statistically significantly improves the peripheral blood flow, and also allows influencing the pathogenesis of the chronic ischemic pain syndrome due to effective efferent blockade, anti-prostaglandine action of the Ketoprophen and blockade of NM DA-receptors.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хронический ишемический болевой синдром</kwd><kwd>эпидуральная анестезия</kwd><kwd>кетопрофен</kwd><kwd>кетамин</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Боль и аналгезия / Машфорд М.Л., Купер М.Г., Кохен М.Л. и др. — М.: Литера, 2004.</mixed-citation><mixed-citation xml:lang="en">Боль и аналгезия / Машфорд М.Л., Купер М.Г., Кохен М.Л. и др. — М.: Литера, 2004.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Казаков Ю.И., Белов И.В., Хатыпов М.Г., Ситкин С.И. // Ангиология и сосудистая хирургия. — 2004. - Т. 10, № 4. - С. 73-77.</mixed-citation><mixed-citation xml:lang="en">Казаков Ю.И., Белов И.В., Хатыпов М.Г., Ситкин С.И. // Ангиология и сосудистая хирургия. — 2004. - Т. 10, № 4. - С. 73-77.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Карпов И.А., Овечкин А.М., Теплых Б.А. // Регионарная анестезия и лечение боли. — М. — Тверь, 2004. - С. 60-63.</mixed-citation><mixed-citation xml:lang="en">Карпов И.А., Овечкин А.М., Теплых Б.А. // Регионарная анестезия и лечение боли. — М. — Тверь, 2004. - С. 60-63.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Кукушкин М.Л. //Боль. - 2003. -№1.- С. 5-12.</mixed-citation><mixed-citation xml:lang="en">Кукушкин М.Л. //Боль. - 2003. -№1.- С. 5-12.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Лебедева Р.Н., Никода В.В. // Фармакотерапия острой боли. — М. :Аир-Арт, 1998. — С. 47—55.</mixed-citation><mixed-citation xml:lang="en">Лебедева Р.Н., Никода В.В. // Фармакотерапия острой боли. — М. :Аир-Арт, 1998. — С. 47—55.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Овечкин А.М., Свиридов С.В. // Регионарная анестезия и лечение острой боли. — 2006. — Т. 1, № 0. — С. 68-69.</mixed-citation><mixed-citation xml:lang="en">Овечкин А.М., Свиридов С.В. // Регионарная анестезия и лечение острой боли. — 2006. — Т. 1, № 0. — С. 68-69.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Осипова Н.А., Никода В.В. //Анестезиология и реаниматология. — 2003. — № 5. — С. 4—9.</mixed-citation><mixed-citation xml:lang="en">Осипова Н.А., Никода В.В. //Анестезиология и реаниматология. — 2003. — № 5. — С. 4—9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Breivik H. // Pain / An Updated Review. - Seattle, 2002. - P. 337-349.</mixed-citation><mixed-citation xml:lang="en">Breivik H. // Pain / An Updated Review. - Seattle, 2002. - P. 337-349.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kehlet H. // Br. 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