On the basis of the treatment of two groups of patients with deep veins thromboses of the legs the schemes of the anti‑coagulant therapy are discussed. It is shown, that simultaneous use of direct and indirect anticoagulants allows to reduce the duration of hospitalization. The use of low initial dozes of indirect anticoagulants (warfarin – 5 mg and less) is not justified owing to prolonged required level of the hypocoagulation.