pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-1631Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESОЦЕНКА ЭФФЕКТИВНОСТИ ПРОТИВОВИРУСНОЙ ТЕРАПИИ С УЧЕТОМ НЕКОТОРЫХ ПОКАЗАТЕЛЕЙ СИСТЕМЫ ЦИТОКИНОВ ПРИ ХРОНИЧЕСКОЙ HCV-ИНФЕКЦИИESTIMATION OF EFFICIENCY OF ANTIVIRUS THERAPY IN VIEW OF SOME PARAMETERS OF SYSTEM OF CYTOKINES AT CHRONIC HCV-INFECTIONСклярЛ. Ф.SklyarL. F.МаркеловаЕ. В.MarkelovaE. V.Владивостокский государственный медицинский университетРоссияVladivostok State Medical UniversityRussian Federation200628122006043135Copyright © Скляр Л.Ф., Маркелова Е.В., 20062006Скляр Л.Ф., Маркелова Е.В.Sklyar L.F., Markelova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/1631

.

The group of patients in amount 45 person received the standard combined therapy by preparations of recombinant IFN-α in combination with ribavirin. The positive effect of standard antivirus treatment at patients with chronic HCV-infection associated with increase of level of IL-2, decrease of levels of TNF-α, IL-1, IL-12р40, IL-12р70 and IL-10 in peripheral serum. It has allowed to use them as noninvasive markers of the steady virologic answer during treatment of a chronic HCV-infection.

вирусный гепатит Сцитокиныбиоптатыкомбинированная терапияReferencesНикулкина Е.Н., Крель П.Е., Лопаткина Т.Н. и др. // Клинич. фармакология и терапия. – 2004. – Т. 13, № 2. – С. 48–52.Никулкина Е.Н., Крель П.Е., Лопаткина Т.Н. и др. // Клинич. фармакология и терапия. – 2004. – Т. 13, № 2. – С. 48–52.Amaraa R., Mareckova H., Urbanek P. et al. // J. Gastroenterology. – 2003. – Vol. 38, No. 3. – P. 254.Amaraa R., Mareckova H., Urbanek P. et al. // J. Gastroenterology. – 2003. – Vol. 38, No. 3. – P. 254.Berg T., Sarrazin C., Herrmann E. et al. // Hepatology. – 2003. – Vol. 37. – P. 600–609.Berg T., Sarrazin C., Herrmann E. et al. // Hepatology. – 2003. – Vol. 37. – P. 600–609.Burroughs A.K. // Liver transpl. – 2000. – Vol. 6, No. 2. – P. 35–40.Burroughs A.K. // Liver transpl. – 2000. – Vol. 6, No. 2. – P. 35–40.Craxi A. // Semin. Liver Dis. – 2003. – Vol. 23, No. 1. – P. 35–46.Craxi A. // Semin. Liver Dis. – 2003. – Vol. 23, No. 1. – P. 35–46.Hadziyannis S.J., Sette ir H., Morgan T.R. et al. // Ann. Intern. Med. – 2004. – Vol. 140. – P. 346–355.Hadziyannis S.J., Sette ir H., Morgan T.R. et al. // Ann. Intern. Med. – 2004. – Vol. 140. – P. 346–355.Gopal D.V., Rabcin J.M., Berk B.S. et al. // Liver transpl. – 2001. – No. 7. – P. 181–190.Gopal D.V., Rabcin J.M., Berk B.S. et al. // Liver transpl. – 2001. – No. 7. – P. 181–190.McHutchison J., Gordon S.C., Schiff E.R. et al. // N. Engl. J. Med. – 1998. – Vol. 339. – P. 1485–1492.McHutchison J., Gordon S.C., Schiff E.R. et al. // N. Engl. J. Med. – 1998. – Vol. 339. – P. 1485–1492.Meurs E. // Virologie. – 1997. – Vol. 1. – P. 481–498.Meurs E. // Virologie. – 1997. – Vol. 1. – P. 481–498.National Institutes of Health Consensus Development Conference Statement: Management of Hepatitis C: 2002 // Hepatology. – 2002. – Vol. 36. – P. 2-20.National Institutes of Health Consensus Development Conference Statement: Management of Hepatitis C: 2002 // Hepatology. – 2002. – Vol. 36. – P. 2-20.Peters M. // Hepatology. – 1996. – Vol. 23. – P. 909–916.Peters M. // Hepatology. – 1996. – Vol. 23. – P. 909–916.Pestka S. // Immunological reviews. – 2004. – Vol. 202. – P. 28–32.Pestka S. // Immunological reviews. – 2004. – Vol. 202. – P. 28–32.Poynard T., McHutchison J., Manns M. et al. // Gastroenterology. – 2002. – Vol. 122. – P. 1303–1313.Poynard T., McHutchison J., Manns M. et al. // Gastroenterology. – 2002. – Vol. 122. – P. 1303–1313.Randall G., Rice C.M. // Curr. Opin. Infect. Dis. – 2001. – Vol. 14. – P. 743–747.Randall G., Rice C.M. // Curr. Opin. Infect. Dis. – 2001. – Vol. 14. – P. 743–747.Wedemeyer H., Cornberg B., Manns M.P. // Liver Immunology / ed. Gershwin. – London : Academic Press, 2003. – Ch. 16. – P. 223–248.Wedemeyer H., Cornberg B., Manns M.P. // Liver Immunology / ed. Gershwin. – London : Academic Press, 2003. – Ch. 16. – P. 223–248.

The authors declare that there are no conflicts of interest present.