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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1632</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>ОЦЕНКА ЗНАЧЕНИЯ ЦИРКУЛИРУЮЩИХ ИММУННЫХ КОМПЛЕКСОВ В ПАТОГЕНЕЗЕ ГЕМОРРАГИЧЕСКОЙ ЛИХОРАДКИ С ПОЧЕЧНЫМ СИНДРОМОМ</article-title><trans-title-group xml:lang="en"><trans-title>ESTIMATION OF VALUE OF CIRCULATING IMMUNE COMPLEXES IN THE PATHOGENESIS OF THE HEMORRHAGIC FEVER WITH RENAL SYNDROME</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максёма</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksyoma</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кушнарева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kushnareva</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слонова</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Slonova</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванис</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanis</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НИИ эпидемиологии и микробиологии СО РАМН;&#13;
Владивостокский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific research institute of epidemiology and microbiology Siberian Branch of the Russian Academy of Medical Science;&#13;
Vladivostok State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2006</year></pub-date><volume>0</volume><issue>4</issue><fpage>35</fpage><lpage>38</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Максёма И.Г., Кушнарева Т.В., Слонова Р.А., Иванис В.А., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Максёма И.Г., Кушнарева Т.В., Слонова Р.А., Иванис В.А.</copyright-holder><copyright-holder xml:lang="en">Maksyoma I.G., Kushnareva T.V., Slonova R.A., Ivanis V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1632">https://www.tmj-vgmu.ru/jour/article/view/1632</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>The results of studying of dynamics of circulating immune complexes at patients with hemorrhagic fever with renal syndrome are shown. The activity of process of formation of complexes depends on a clinical variant of illness only in early terms and reaches the maximal values by the 3rd week of disease. It is found, that in the feverish period of illness the circulating immune complexes of big size prevail. The dynamics of circulation of an antigen of a virus in blood is investigated as well as in structure of immune complexes. It is shown, that along with decrease in the maintenance of hantavirus antigen in blood by the period of early recovery there is an essential increase of frequency of detection of specific antigen in structure of circulating immune complexes.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>геморрагическая лихорадка с почечным синдромом</kwd><kwd>патогенез</kwd><kwd>циркулирующие иммунные комплексы</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Владимирова Т.П. // Автореф. дис. ... докт. биол. наук. – Хабаровск, 1997.</mixed-citation><mixed-citation xml:lang="en">Владимирова Т.П. // Автореф. дис. ... докт. биол. наук. – Хабаровск, 1997.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гавриловская И.Н., Подгородниченко В.К., Апекина Н.С. и др. // Микробиол. журн. – 1987. – Т. 49, № 4. – С. 71–76.</mixed-citation><mixed-citation xml:lang="en">Гавриловская И.Н., Подгородниченко В.К., Апекина Н.С. и др. // Микробиол. журн. – 1987. – Т. 49, № 4. – С. 71–76.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Гриневич Ю.А., Алферов А.Н. // Лабораторное дело. – 1981. – № 8. – С. 493–495.</mixed-citation><mixed-citation xml:lang="en">Гриневич Ю.А., Алферов А.Н. // Лабораторное дело. – 1981. – № 8. – С. 493–495.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Дадаева А.А., Сизикова Л.П., Чепурнов А.А. // Вопр. вирусологии. – 2004. – № 2. – С. 11–18.</mixed-citation><mixed-citation xml:lang="en">Дадаева А.А., Сизикова Л.П., Чепурнов А.А. // Вопр. вирусологии. – 2004. – № 2. – С. 11–18.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Иванис В.А. // Автореф. дис. ... докт. мед. наук. – Владивосток, 2004.</mixed-citation><mixed-citation xml:lang="en">Иванис В.А. // Автореф. дис. ... докт. мед. наук. – Владивосток, 2004.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Малинина Т.А., Рябов В.И., Малинин О.В. // Журн. микробиол. – 1994. – № 1. – С. 100–103.</mixed-citation><mixed-citation xml:lang="en">Малинина Т.А., Рябов В.И., Малинин О.В. // Журн. микробиол. – 1994. – № 1. – С. 100–103.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Морозов В.Г. // Автореф. дис. ... канд. мед. наук. – СПб., 1993.</mixed-citation><mixed-citation xml:lang="en">Морозов В.Г. // Автореф. дис. ... канд. мед. наук. – СПб., 1993.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Первиков Ю.В., Эльберт Л.Б. 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