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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1635</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>ИММУНОЛОГИЧЕСКИЕ МЕХАНИЗМЫ ПРОГРЕССИРОВАНИЯ ГЕСТОЗА</article-title><trans-title-group xml:lang="en"><trans-title>IMMUNOLOGICOL MECHANISMS IN THE PROGRESS OF GESTOSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щербавская</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shcherbavskaya</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ДВ филиал НЦ медицинской экологии ВСНЦ СО РАМН;&#13;
Краевой клинический центр охраны материнства и детства</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Far-Eastern Branch of the Scientific Center of medical ecology Russian Scientific Center;&#13;
Siberian Branch of the RAMS;&#13;
Regional Clinical Center of Mother and Child Protection</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2006</year></pub-date><volume>0</volume><issue>4</issue><fpage>47</fpage><lpage>50</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Щербавская Э.А., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Щербавская Э.А.</copyright-holder><copyright-holder xml:lang="en">Shcherbavskaya E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1635">https://www.tmj-vgmu.ru/jour/article/view/1635</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α were measured in 130 pregnant women with different severity of gestosis. It was established, that the production of proinflammatory cytokines is increased and the rate of antiinflammatory cytokines is decreased in the patients with gestosis in comparison with women with physiological pregnancy. The severity of disorders of the cytokine status are in proportion with the severity of gestosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>провоспалительные цитокины</kwd><kwd>противовоспалительные цитокины</kwd><kwd>гестоз</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Витковский Ю.А., Белокриницкая Т.Е., Кузник Б.И. // Акушерство и гинекология. – 1998. – № 3. – С. 13–15.</mixed-citation><mixed-citation xml:lang="en">Витковский Ю.А., Белокриницкая Т.Е., Кузник Б.И. // Акушерство и гинекология. – 1998. – № 3. – С. 13–15.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кашкин К.П. // Клинич. лаб. диагностика. – 1998. – № 11. – С. 21–32.</mixed-citation><mixed-citation xml:lang="en">Кашкин К.П. // Клинич. лаб. диагностика. – 1998. – № 11. – С. 21–32.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Киншт Д.Н., Верещагин Е.И., Пасман Н.М., Верещагин И.П. // Вестн. интенсивной терапии. – 1999. – № 2. – С. 23–28.</mixed-citation><mixed-citation xml:lang="en">Киншт Д.Н., Верещагин Е.И., Пасман Н.М., Верещагин И.П. // Вестн. интенсивной терапии. – 1999. – № 2. – С. 23–28.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Криворучко А.Ю., Аксененко В.А., Квочко А.Н., Павлов Р.В. // Журн. акушерства и женских болезней. – 2000. – № 4. – С. 82–85.</mixed-citation><mixed-citation xml:lang="en">Криворучко А.Ю., Аксененко В.А., Квочко А.Н., Павлов Р.В. // Журн. акушерства и женских болезней. – 2000. – № 4. – С. 82–85.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Лященко А.А., Уваров В.Ю. // Доказательная медицина и молекулярная терапия в клинике внутр. болезней : сборник научных трудов, посвященный 240-летию ММА им И.М. 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