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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1751</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURES</subject></subj-group></article-categories><title-group><article-title>ОСОБЕННОСТИ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ ДЕТСКОГО ВОЗРАСТА</article-title><trans-title-group xml:lang="en"><trans-title>FEATURES OF CLINICAL PHARMACOLOGY IN CHILDREN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лозинский</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Lozinsky</surname><given-names>E. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елисеева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Eliseeva</surname><given-names>E. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шмыкова</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Shmikova</surname><given-names>I. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галанова</surname><given-names>Ю. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Galanova</surname><given-names>Yu. D.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Владивостокский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vladivostok State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2005</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2005</year></pub-date><volume>0</volume><issue>3</issue><fpage>14</fpage><lpage>18</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лозинский Е.Ю., Елисеева Е.В., Шмыкова И.И., Галанова Ю.Д., 2005</copyright-statement><copyright-year>2005</copyright-year><copyright-holder xml:lang="ru">Лозинский Е.Ю., Елисеева Е.В., Шмыкова И.И., Галанова Ю.Д.</copyright-holder><copyright-holder xml:lang="en">Lozinsky E.Y., Eliseeva E.V., Shmikova I.I., Galanova Y.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1751">https://www.tmj-vgmu.ru/jour/article/view/1751</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>Our presentation includes physiological peculiarities of a child's development. It reveals a relationship between physiology of different age groups and clinical pharmacology of medications. Absorption, distribution, biotransformation and elimination of drugs vary in different age periods depending on the development of child's internal organs and systems. Mechanisms of pharmacologic effects of medications, development of side effects and drug addiction are discussed according to age characteristics of clinical pharmacology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фармакокинетика</kwd><kwd>фармакодинамика</kwd><kwd>педиатрия</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гусель В.А., Маркова И.В. Справочник педиатра по клинической фармакологии. — Л. : Медицина, 1989.</mixed-citation><mixed-citation xml:lang="en">Гусель В.А., Маркова И.В. 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