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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1761</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>ОСОБЕННОСТИ ЦИТОКИНОВОГО ПРОФИЛЯ И ИММУННОГО СТАТУСА ПРИ АЛЛЕРГИЧЕСКИХ ЗАБОЛЕВАНИЯХ У ДЕТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>FEATURES OF THE CYTOKINE STRUCTURE AND IMMUNE STATUS AT ALLERGIC DISEASES IN CHILDREN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Просекова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Prosekova</surname><given-names>E. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Деркач</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Derkach</surname><given-names>V. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шестовская</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shestovskaya</surname><given-names>T. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нетесова</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Netesova</surname><given-names>S. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>Yu. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Владивостокский государственный медицинский университет; Дальневосточный филиал НИИ клинической иммунологии СО РАМН; Детская городская клиническая больница (г. Владивосток)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vladivostok State Medical University; Far East Branch of Scientific Research Institute of Clinical Immunology of Siberian Branch of the RAMS; Children's City Hospital (Vladivostok)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2005</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2005</year></pub-date><volume>0</volume><issue>3</issue><fpage>44</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Просекова Е.В., Деркач В.В., Шестовская Т.Н., Нетесова С.Ю., Иванова Ю.В., 2005</copyright-statement><copyright-year>2005</copyright-year><copyright-holder xml:lang="ru">Просекова Е.В., Деркач В.В., Шестовская Т.Н., Нетесова С.Ю., Иванова Ю.В.</copyright-holder><copyright-holder xml:lang="en">Prosekova E.V., Derkach V.V., Shestovskaya T.N., Netesova S.Y., Ivanova Y.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1761">https://www.tmj-vgmu.ru/jour/article/view/1761</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>The changes in of the immune response in 300 children in the age of 3—15 years, suffering of allergic rhinitis, asthma and atopic dermatitis are investigated. In various biological material the contents of cytokines and antibodies was determined, the ratio of lymphocytes and phagocytosis parameters of peripheral blood cells was studied. It is shown, that algorithms of cytokine changes reflect a degree and an orientation of an allergic inflammation, immune changes, determine the severity of pathological process and prove the necessity of the immunotrope therapy at these diseases.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>цитокины</kwd><kwd>иммунный статус</kwd><kwd>аллергические заболевания</kwd><kwd>дети</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Адо А.Д. Общая аллергология. — М. : Медицина, 1978.</mixed-citation><mixed-citation xml:lang="en">Адо А.Д. 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