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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1782</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>ГЕНЕТИЧЕСКИЕ АСПЕКТЫ ОСТЕОПОРОЗА</article-title><trans-title-group xml:lang="en"><trans-title>GENETIC ASPECTS OF OSTEOPOROSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кочеткова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kochetkova</surname><given-names>E. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бубнов</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Bubnov</surname><given-names>O. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильева</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilieva</surname><given-names>T. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белых</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Belykh</surname><given-names>O. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Владивостокский государственный медицинский университет; Владивостокский филиал НИИ медицинской генетики ТНЦ СО РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vladivostok State Medical University; Vladivostok Branch of Research Centre of Medical Genetics (Tomsk Research Centre of the Siberian Branch of RAMS)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2005</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2005</year></pub-date><volume>0</volume><issue>2</issue><fpage>14</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кочеткова Е.А., Бубнов О.Ю., Васильева Т.Г., Белых О.А., 2005</copyright-statement><copyright-year>2005</copyright-year><copyright-holder xml:lang="ru">Кочеткова Е.А., Бубнов О.Ю., Васильева Т.Г., Белых О.А.</copyright-holder><copyright-holder xml:lang="en">Kochetkova E.A., Bubnov O.Y., Vasilieva T.G., Belykh O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1782">https://www.tmj-vgmu.ru/jour/article/view/1782</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>This paper provides a literature review on a role of genetic factors in developing osteoporosis. The authors give data on the current investigations of genes that encode vitamin D receptors and I type collagen metabolism, and their effect on mineral bone density. They also highlight that the testing of genes-candidates responsible for pre-osteoporosis provides insight into early pre-clinical detection of patients who are very likely to risk getting this disease in various forms.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>генетика</kwd><kwd>остеопороз</kwd><kwd>гены-кандидаты</kwd><kwd>минеральная плотность костной ткани</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Зазерская И.Е., Асеев М.В., Кузнецова Л.В. //Остеопороз и остеопатии. — 2002. — № 2. — С. 2—6.</mixed-citation><mixed-citation xml:lang="en">Зазерская И.Е., Асеев М.В., Кузнецова Л.В. //Остеопороз и остеопатии. — 2002. — № 2. — С. 2—6.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Короткова Т.А. // Остеопороз и остеопатии. — 2004. -№3.- С. 34-37.</mixed-citation><mixed-citation xml:lang="en">Короткова Т.А. // Остеопороз и остеопатии. — 2004. -№3.- С. 34-37.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Крылов М.Ю., Мякоткин В.А., Беневоленская Л.И. //Материалы I Российского конгресса по остеопорозу. - 2003. - С. 30.</mixed-citation><mixed-citation xml:lang="en">Крылов М.Ю., Мякоткин В.А., Беневоленская Л.И. //Материалы I Российского конгресса по остеопорозу. - 2003. - С. 30.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Мякоткин В.А. // Материалы I Российского конгресса по остеопорозу. — 2003. — С. 27—29.</mixed-citation><mixed-citation xml:lang="en">Мякоткин В.А. // Материалы I Российского конгресса по остеопорозу. — 2003. — С. 27—29.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Beavan S.//Lancet. - 1996. - Vol. 348. - P. 136-137.</mixed-citation><mixed-citation xml:lang="en">Beavan S.//Lancet. - 1996. - Vol. 348. - P. 136-137.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Dawson P.A.//J. 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