Objective. To reveal the peculiarities of distribution and potential interrelations of tobacco smoking with other cardiovascular risk's factors in the population of Primorsky Krai in different age groups. Methods. 2117 people, living in the Primorsky Territory, were examined during a multicentre epidemiological study. All patients completed the questionnaire, conducted an instrumental examination, and venous blood sampling was performed to determine the lipid spectrum and other major biochemical parameters that affect cardiovascular risk. Results. There was a direct relationship between the weight and circumference of the waist, the level of triglycerides on age and smoking status revealed in the course of the study. The indices of systolic and diastolic blood pressure, total cholesterol, low-density lipoprotein, apolipoprotein B, glucose values were correlated with age and did not depend on smoking status. The indices of apolipoprotein A and uric acid were influenced by the status of smoking and did not depend on age. In other biochemical indicators, the dependence on smoking status and age was not revealed. Conclusions. Currently being considered personalized prognostic and predictive approach to the prevention of premature aging and cardiovascular risk, based on the active participation of the patient. Tobacco Smoking is associated with impaired metabolic processes, in particular a change in the number of lipid metabolism and uric acid. With the aim of individualization of prevention approaches can have the value of monitoring indicators triglycerides, apolipoproteins, uric acid, in connection with a possible participation of this factor in the formation of adverse metabolic phenotype. Exceptionally important is the need for the implementation of primary prevention programs aimed at promoting a healthy lifestyle, quitting Smoking and other addictions as the general population and individual levels.