pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.17238/PmJ1609-1175.2017.4.65-68pmj-187Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESЧастота аллелей и генотипов полиморфизма гена C-реактивного белка у женщин с ишемической болезнью сердца и постменопаузальным остеопорозомThe frequency of alleles and genotypes of polymorphism of C-reactive protein gene in women with ischemic heart disease and postmenopausal osteoporosisЦаренокС. Ю.TsarenokS. Yu.sveta-tsarenok@yandex.ruГорбуновВ. В.GorbunovV. V.noemail@neicon.ruДутоваА. А.DutovaA. A.noemail@neicon.ruЧитинская государственная медицинская академияРоссияChita State Medical AcademyRussian Federation201728122017046568Copyright © Царенок С.Ю., Горбунов В.В., Дутова А.А., 20172017Царенок С.Ю., Горбунов В.В., Дутова А.А.Tsarenok S.Y., Gorbunov V.V., Dutova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/187

На основе полимеразной цепной реакции изучена частота встречаемости аллелей и генотипов полиморфизмов С1444Т, С1846Т, С3872Т и A717G гена С-реактивного белка (СРБ) у 205 женщин русской национальности 60-76 лет, 162 из которых страдали ишемической болезнью сердца (ИБС), в т.ч. 76 - в сочетании с остеопорозом. При ИБС выявлены статистически значимые различия в распределении аллелей и генотипов для полиморфизмов СРБ С3872Т и С1444Т по сравнению со здоровыми лицами. При этом среди здоровых чаще обнаруживается аллель Т и гомозиготный генотип ТТ полиморфного участка С3872Т. У пациенток с ИБС аллель Т и генотип ТT полиморфизма С1444Т встречались чаще и были ассоциированы с увеличением риска ИБС в 1,5 раза. Не найдено взаимосвязи между наличием остеопороза и полиморфизмами СРБ. Установлено, что полиморфизм С1444Т ассоциирован с переломами лучевой кости, при носительстве генотипа СС их риск повышался в 1,5 раза. Полиморфизм С1846Т был связан с опасностью позвоночных переломов: у носителей генотипа СТ риск переломов этой локализации повышался в 4,5 раза.

Objective. Aim: to study the frequency of alleles and genotypes of polymorphisms of the C-reactive protein (CRP) gene (С1444Т, С1846Т; С3872Т; A717G) in women with ischemic heart disease (IHD) and osteoporosis. Methods. 205 postmenopausal women aged from 60 to 76 years, living in the Trans-Baikal Territory, Russian nationality were examined. In 162 women, the diagnosis of IHD was verified, among them 76 postmenopausal osteoporosis (the first clinical group) was detected. 86 women with IHD (without osteoporosis) made up the second clinical group. 43 women of the control group did not have a risk of cardiovascular diseases and osteoporosis. Molecular genetic investigation was performed by polymerase chain reaction. Results. A statistically significant difference in the distribution of alleles and genotypes for CRP polymorphisms: C3872T and C1444T was found in women with IHD comparison with healthy individuals. The T allele and the homozygous TT genotype of the polymorphic region C3872T were more often detected among healthy individuals. For polymorphism С1444Т it was established that in patients with IHD allele T and genotype TT were more frequent and associated with an increase in the risk of IHD by 1.5 times. We have not identified the relationship between the presence of osteoporosis and the studied polymorphisms of CRP. We studied the distribution of alleles and genotypes depending on the localization of fractures. It was established that C1444T polymorphism is associated with fractures of the radial bone, polymorphism С1846Т is associated with an increased risk of vertebral fractures. Conclusions. C3872T and C1444T polymorphisms of the CRP gene are associated with IHD. In carriers of T allele and CT genotype of C1444T polymorphism, the risk of IHD increased 1.5 times. We did not find any differences in the distribution of alleles and genotypes of the studied polymorphisms when comparing women who have a combination of IHD and osteoporosis with women with IHD. The risk of development of fractures of the radial bone is associated with polymorphism C1444T. For women with CC genotype, the risk is increased by 1.5 times. The risk of vertebral fractures is associated with polymorphism C1846T. The carriers of CT genotype risk increased by 4.5 times.

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The authors declare that there are no conflicts of interest present.