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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pmj-1919</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>ЗНАЧЕНИЕ ЦИТОКИНОВОГО СТАТУСА В ИЗУЧЕНИИ ИММУНОПАТОГЕНЕЗА ИНФЕКЦИОННЫХ БОЛЕЗНЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>IMPORTANCE OF CYTOKINE STATE IN RESEARCHING INTO THE IMMUNOPATHOGENESIS OF INFECTIOUS DISEASES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванис</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanis</surname><given-names>V. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маркелова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Markelova</surname><given-names>E. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скляр</surname><given-names>Л. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Sklyar</surname><given-names>L. F.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симакова</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Simakova</surname><given-names>A. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мандракова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mandrakova</surname><given-names>N. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Владивостокский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vladivostok State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2004</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2004</year></pub-date><volume>0</volume><issue>2</issue><fpage>36</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иванис В.А., Маркелова Е.В., Скляр Л.Ф., Симакова А.И., Мандракова Н.В., 2004</copyright-statement><copyright-year>2004</copyright-year><copyright-holder xml:lang="ru">Иванис В.А., Маркелова Е.В., Скляр Л.Ф., Симакова А.И., Мандракова Н.В.</copyright-holder><copyright-holder xml:lang="en">Ivanis V.A., Markelova E.V., Sklyar L.F., Simakova A.I., Mandrakova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/1919">https://www.tmj-vgmu.ru/jour/article/view/1919</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>The paper provides data on the researches into the cytokine state under hemorrhagic fever with renal syndrome, chronic viral hepatitis type C, ixode tickborreliosis, and nosocomial pneumonias. The authors have inquired into the content of proinflammatory and anti-inflammatory cytokines at system and local levels (in blood serum, bronchoalveolar fluid supernatants, liver homogenate, expired air condensate). According to the findings, infectious disease pathogens are initiators of the infectious process, and the so-called «direction» in pathogeny belongs to organism immune response that detects the severity, clinical course and form of the disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекционные болезни</kwd><kwd>цитокины</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Васильева Г.И., Иванова И.А., Тюкавкина С.Ю.// Медицинская иммунология. — 2001. — Т.1, № 12. — С. 1101-1111.</mixed-citation><mixed-citation xml:lang="en">Васильева Г.И., Иванова И.А., Тюкавкина С.Ю.// Медицинская иммунология. — 2001. — Т.1, № 12. — С. 1101-1111.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Зубков М.Н., Зубков М.М.// Consilium Medicum. — 2000. - Т. 2, № 1. - С. 32-38.</mixed-citation><mixed-citation xml:lang="en">Зубков М.Н., Зубков М.М.// Consilium Medicum. — 2000. - Т. 2, № 1. - С. 32-38.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Иванис В.А., Маркелова Е.В.// Цитокины и воспаление. - 2002. - Т. 1, № 2. - С. 114-115.</mixed-citation><mixed-citation xml:lang="en">Иванис В.А., Маркелова Е.В.// Цитокины и воспаление. - 2002. - Т. 1, № 2. - С. 114-115.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Леонова Г.Н., Якушева С.С., Иванис В.А. и др.// Эпидемиология и инфекционные болезни. — 2002. — № 1. - С. 49-53.</mixed-citation><mixed-citation xml:lang="en">Леонова Г.Н., Якушева С.С., Иванис В.А. и др.// Эпидемиология и инфекционные болезни. — 2002. — № 1. - С. 49-53.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Лобзин Ю.В., Усков А.Н., Козлов С.С. 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