The authors give consideration to the features of comprehensive blood-saving approach in cardiosurgery, which includes autoblood purveyance, erythropoietin and hypoxic therapies, minimization of volume of pump oxygenator primary filling, preperfusion autoblood sampling, postperfusion blood ultrafiltration, autoblood reinfusion and drain discharge return, hemostasis system correction, and early nutritious support. The blood-saving procedures in practice allowed maintaining the homeostasis indexes in the course of operation and during early postoperative period at optimum level. Favorable outcomes at patients having been operated using bloodless technique testify its efficacy and safety.