pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.17238/PmJ1609-1175.2018.1.11-15pmj-198Research ArticleОБЗОРЫREVIEWSРоль полиморфизма генов в развитии различных вариантов острого и хронического панкреатитаTHE ROLE OF GENE POLYMORPHISM IN THE DEVELOPMENT OF VARIOUS VARIANTS OF ACUTE AND CHRONIC PANCREATITISРаповкаВ. Г.RapovkaV. G.primvasc@mail.ruЗаводовК. А.ZavodovK. A.noemail@neicon.ruСоболевскаяО. А.SobolevskayaO. A.noemail@neicon.ruСарвановИ. А.SarvanovI. V.noemail@neicon.ruТихоокеанский государственный медицинский университетRussian Federation201828032018011115Copyright © Раповка В.Г., Заводов К.А., Соболевская О.А., Сарванов И.А., 20182018Раповка В.Г., Заводов К.А., Соболевская О.А., Сарванов И.А.Rapovka V.G., Zavodov K.A., Sobolevskaya O.A., Sarvanov I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/198

Проанализирована роль полиморфизма генов в развитии деструктивных форм острого панкреатита. На основании обзора литературных данных установлено, что для профилактики деструктивного панкреатита наиболее перспективно определение мутаций гена секреторного ингибитора трипсина SP1NK1. Литературные данные указывают, что мутации гена катионного трипсиногена и гена трансмембранного регуляторного белка муковисцидоза могут иметь значение только в комплексе с другими маркерами. Наиболее высокий риск развития деструктивного панкреатита возникает у пациентов с сочетанными мутациями.

The role of gene polymorphism in the development of destructive forms of acute pancreatitis was analyzed. Based on the review of literature data, it has been established that the most promising for the prevention of destructive pancreatitis is the determination of mutations in the secretory trypsin inhibitor gene SP1NK1. The literature data indicate that the mutations of the cationic trypsinogen gene and the gene of the transmembrane regulatory protein of cystic fibrosis can only be important in conjunction with other markers. Patients with combined mutations have the highest risk of developing destructive pancreatitis.

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The authors declare that there are no conflicts of interest present.