<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34215/1609-1175-2020-4-59-62</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-2125</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>Генерация вторичного излучения на поверхности эндопротезов, используемых для реконструкции молочной железы при мастэктомии, после проведения лучевой терапии</article-title><trans-title-group xml:lang="en"><trans-title>Generation of secondary radiation on the surface of endoprostheses used for breast reconstruction during mastectomy, after radiation therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7072-1688</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гулян</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Gulian</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент института хирургии, 690002, г. Владивосток, пр-т Острякова, 2;</p><p>врач Медицинского центра </p></bio><bio xml:lang="en"><p>MD, assistant, Institute of Surgery, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">isabella.g@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никифорова</surname><given-names>Н. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikiforova</surname><given-names>N. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>student, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">12089515@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кустов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kustov</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ведущий научный сотрудник,</p><p>690034, г. Владивосток, ул. Фадеева, 31</p></bio><bio xml:lang="en"><p>leading researcher, </p><p>31 Fadeeva St., Vladivostok, 690034</p></bio><email xlink:type="simple">kvn-om@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Темченко</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Temchenko</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ведущий научный сотрудник,</p><p>690034, г. Владивосток, ул. Фадеева, 31</p></bio><bio xml:lang="en"><p>leading researcher, </p><p>31 Fadeeva St., Vladivostok, 690034</p></bio><email xlink:type="simple">umc_tkdrm@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мандрыко</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Mandryko</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>student, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Невожай</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Nevozhay</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор  Института хирургии,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>MD, PhD, professor of the Institute of Surgery, </p><p>(2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">nevozhai@mail.primorye.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панкратов</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pankratov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший медицинский физик,</p><p>690069, г. Владивосток, ул. Русская, 57а</p></bio><bio xml:lang="en"><p>senior medical physicist, </p><p>57a Russkaya St., Vladivostok, 690069</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Матвиенко</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Matvienko</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>медицинский физик,</p><p>690069, г. Владивосток, ул. Русская, 57а</p></bio><bio xml:lang="en"><p>medical physicist, </p><p>57a Russkaya St., Vladivostok, 690069</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рудюк</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudyuk</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>медицинский физик,</p><p>690069, г. Владивосток, ул. Русская, 57а</p></bio><bio xml:lang="en"><p>medical physicist, </p><p>57a Russkaya St., Vladivostok, 690069</p></bio><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет;&#13;
Дальневосточный федеральный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University;&#13;
Far East Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Владивостокский филиал Государственной таможенной академии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vladivostok Branch of the Customs Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет;&#13;
Приморский краевой онкологический диспансер</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University;&#13;
Primorsky Regional Oncologic Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Приморский краевой онкологический диспансер</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Primorsky Regional Oncologic Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2020</year></pub-date><volume>0</volume><issue>4</issue><fpage>59</fpage><lpage>62</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гулян И.С., Никифорова Н.О., Кустов В.Н., Темченко В.В., Мандрыко А.С., Невожай В.И., Панкратов И.В., Матвиенко Н.А., Рудюк В.П., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Гулян И.С., Никифорова Н.О., Кустов В.Н., Темченко В.В., Мандрыко А.С., Невожай В.И., Панкратов И.В., Матвиенко Н.А., Рудюк В.П.</copyright-holder><copyright-holder xml:lang="en">Gulian I.S., Nikiforova N.O., Kustov V.N., Temchenko V.V., Mandryko A.S., Nevozhay V.I., Pankratov I.V., Matvienko N.A., Rudyuk V.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/2125">https://www.tmj-vgmu.ru/jour/article/view/2125</self-uri><abstract><sec><title>Цель</title><p>Цель: экспериментальная оценка вторичного излучения на поверхности имплантатов и  экспандеров, используемых для реконструкции молочной железы при мастэктомии, после проведения лучевой терапии.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. На базе радиологического отделения ПКОД была собрана установка, состоящая из линейного ускорителя, как источника ионизирующего излучения, и гамма-спектрометра с детектором на основе сверхчистого германия. Объектами исследования были имплантаты и экспандер различных производителей.</p></sec><sec><title>Результаты</title><p>Результаты. Максимальное число вторичных фотонов на имплантатах и эспандере генерировалось при энергиях ниже 700 кэВ. На поверхности имплантатов уровень генерации вторичных фотонов в зоне энергий 600–300 кэВ был выше, чем на поверхности экспандера, заполненного физиологическим раствором.</p></sec><sec><title>Заключение</title><p>Заключение. При воздействии тормозного ионизирующего излучения на силиконовые имплантаты и тканевой экспандер, заполненный физиологическим раствором, генерируются фотоны вторичного излучения с энергией в диапазоне от 100 до 700 кэВ, что может служить одной из причин развития капсулярных контрактур после мастэктомии. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: Experimental estimate of the secondary radiation on the surface of implants and expanders, used for breast reconstruction in case of mastectomy, after making radiation therapy.</p></sec><sec><title>Methods</title><p>Methods: Special equipment was constructed by radiation study department. It consists of linear accelerator as a source of ionizing radiation and a gamma-ray spectrometer with the detector on the basis of ultrapure germanium. The objects of research were the implants and expanders of the different producers.</p></sec><sec><title>Results</title><p>Results: The maximum amount of the secondary photons on the implants and expanders was generated on the energy level lower than 700 KEV. The level of photons’ generation between 600–300 KEV was higher on the surface of the implants than on the surface of expander filled with saline.</p></sec><sec><title>Conclusion</title><p>Conclusion: The photons of the secondary radiation with the energy level from 100 to 700 KEV are generated under the influence of ionizing radiation on the implants and tissue expander filled with saline. It can be one of the causes of capsular contractures development after mastectomy. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>лечение</kwd><kwd>имплантат</kwd><kwd>экспандер</kwd><kwd>капсулярная контрактура</kwd></kwd-group><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>treatment</kwd><kwd>implant</kwd><kwd>expander</kwd><kwd>capsular contracture</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Состояние онкологической помощи населению России в 2017 году. Под редакцией А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М., 2018.</mixed-citation><mixed-citation xml:lang="en">Kaprin AD, Starinsky VV, Petrova GV, eds. The situation of oncological assistance to the population of Russia in 2017. Moscow; 2018 (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Зернов К.Ю., Дашян Г.А., Криворотько П.В., Новиков С.Н., Палтуев Р.М., Табагуа Т.Т. и др. Реконструкция молочной железы и лучевая терапия. Злокачественные опухоли. 2017;22(1):30–6.</mixed-citation><mixed-citation xml:lang="en">Zernov KY, Dashyan GA, Krivorotko PV, Novikov SN, Paltuev RM, Tabagua TT, et al. Breast reconstruction and radiotherapy. Malignant Tumors. 2017;22(1):30–6 (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Зикиряходжаев А.Д., Широких И.М., Аблицова Н.В. , Ермощенкова Н.В., Харченко Н.В., Сарибекян Н.К. и др. Использование биологических и синтетических материалов в реконструктивной хирургии при раке молочной железы (обзор литературы). Опухоли женской репродуктивной системы. 2018;14(1):28–37.</mixed-citation><mixed-citation xml:lang="en">Zikiryakhodzhaev AD, Shirokikh IM, Ablitsova NV, Ermoshchenkova MV, Kharchenko NV, Saribekyan EK, et al. Biological and synthetic materials in reconstructive surgery for breast cancer treatment (Literature review). Tumors of Female Reproductive System. 2018;14(1):28–37 (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hennequin C, Barillot I, Azria D, Belkacemi Y, Bollet M, Chauvet B, et al. Radiotherapy of breast cancer. Cancer Radiotherapy. 2016;20:139–46.</mixed-citation><mixed-citation xml:lang="en">Hennequin C, Barillot I, Azria D, Belkacemi Y, Bollet M, Chauvet B, et al. Radiotherapy of breast cancer. Cancer Radiotherapy. 2016;20:139–46.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Aristei C, Falcinelli L, Bini V. Expander/implant breast reconstruction before radiotherapy: outcomes in a single-institute cohort. Strahlenther Onkol. 2012;188(12):1074–9.</mixed-citation><mixed-citation xml:lang="en">Aristei C, Falcinelli L, Bini V. Expander/implant breast reconstruction before radiotherapy: outcomes in a single-institute cohort. Strahlenther Onkol. 2012;188(12):1074–9.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Benediktsson K, Perbeck L. Capsular contracture around salinefilled and textured subcutaneously-placed implants in irradiated and non-irradiated breast cancer patients: five years of monitoring of a prospective trial. J Plast Reconstr Aesthet Surg. 2006;59(1):27–34.</mixed-citation><mixed-citation xml:lang="en">Benediktsson K, Perbeck L. Capsular contracture around salinefilled and textured subcutaneously-placed implants in irradiated and non-irradiated breast cancer patients: five years of monitoring of a prospective trial. J Plast Reconstr Aesthet Surg. 2006;59(1):27–34.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kim I, Park SO, Chang H. Ung Sik Jin. inhibition mechanism of acellular dermal matrix on capsule formation in expander–implant breast reconstruction after postmastectomy radiotherapy. Ann Surg Oncol. 2018;25:2279–87.</mixed-citation><mixed-citation xml:lang="en">Kim I, Park SO, Chang H. Ung Sik Jin. inhibition mechanism of acellular dermal matrix on capsule formation in expander–implant breast reconstruction after postmastectomy radiotherapy. Ann Surg Oncol. 2018;25:2279–87.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Salzberg CA, Ashikari AY, Berry C, Hunsicker LM. Acellular dermal matrix-assisted direct-to-implant breast reconstruction and capsular contracture: A 13-year experience. Plast Reconstr Surg. 2016;138(2):329–37.</mixed-citation><mixed-citation xml:lang="en">Salzberg CA, Ashikari AY, Berry C, Hunsicker LM. Acellular dermal matrix-assisted direct-to-implant breast reconstruction and capsular contracture: A 13-year experience. Plast Reconstr Surg. 2016;138(2):329–37.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Valdatta L, Cattaneo AG, Pellegatta I, Scamoni S, Minuti A, Cherubino M. Acellular dermal matrices and radiotherapy in breast reconstruction: A systematic review and meta-analysis of the literature. Plast Surg Int. 2014;472604. doi: 10.1155/2014/472604</mixed-citation><mixed-citation xml:lang="en">Valdatta L, Cattaneo AG, Pellegatta I, Scamoni S, Minuti A, Cherubino M. Acellular dermal matrices and radiotherapy in breast reconstruction: A systematic review and meta-analysis of the literature. Plast Surg Int. 2014;472604. doi: 10.1155/2014/472604</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pompei S, Arelli F, Labardi L, Marcasciano F, Evangelidou D, Ferrante G. Polyurethane implants in 2-stage breast reconstruction: 9-year clinical experience. Aesthet Surg J. 2017;37(2):171–6.</mixed-citation><mixed-citation xml:lang="en">Pompei S, Arelli F, Labardi L, Marcasciano F, Evangelidou D, Ferrante G. Polyurethane implants in 2-stage breast reconstruction: 9-year clinical experience. Aesthet Surg J. 2017;37(2):171–6.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Amoresano A, Stefano L, Rea I. Chemical and structural characterization of several mid-term explanted breast prostheses. Materials (Basel). 2016;9(8):E678. doi: 10.3390/ma9080678</mixed-citation><mixed-citation xml:lang="en">Amoresano A, Stefano L, Rea I. Chemical and structural characterization of several mid-term explanted breast prostheses. Materials (Basel). 2016;9(8):E678. doi: 10.3390/ma9080678</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Freitas RA Jr. Human body chemical composition. Nanomedicine. 1999. URL: https://foresight.org/Nanomedicine/Ch03_1.php (Accessed: 4 June 2020).</mixed-citation><mixed-citation xml:lang="en">Freitas RA Jr. Human body chemical composition. Nanomedicine. 1999. URL: https://foresight.org/Nanomedicine/Ch03_1.php (Accessed: 4 June 2020).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Костылев В.А., Наркевич Б.Я. Медицинская физика. М.: Медицина, 2008. [Kostylev VA, Narkevich BYa. Medical physics. Moscow: Medicine; 2008. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Kostylev VA, Narkevich BYa. Medical physics. Moscow: Medicine; 2008. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chuba PJ, Stefani WA, Dul C, Szpunar S, Falk J, Wagner R, et al. Radiation and depression associated with complications of tissue expander reconstruction. Breast Cancer Res Treat. 2017;164(3):641–7.</mixed-citation><mixed-citation xml:lang="en">Chuba PJ, Stefani WA, Dul C, Szpunar S, Falk J, Wagner R, et al. Radiation and depression associated with complications of tissue expander reconstruction. Breast Cancer Res Treat. 2017;164(3):641–7.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
