<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34215/1609-1175-2020-4-90-92</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-2133</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТОДИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METHODS</subject></subj-group></article-categories><title-group><article-title>Практическое использование метода клеточных блоков для диагностики новообразований поджелудочной железы и опухолевых процессов других локализаций</article-title><trans-title-group xml:lang="en"><trans-title>Practical application of the cell block technique for the diagnostics of the tumors of the pancreas and of other localizations</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4382-7046</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коцюрбий</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotsyrbiy</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, заведующий кафедрой патологической анатомии и судебной медицины, </p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>MD, PhD, head of the Dept. of Pathology and Medical Jurisprudence, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">gpab@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тихонов</surname><given-names>Я. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tychonov</surname><given-names>Y. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший преподаватель кафедры патологической анатомии и судебной медицины, 690002, г. Владивосток, пр-т Острякова, 2;</p><p> врач, 690002, г. Владивосток, пр-т Острякова, 4</p></bio><bio xml:lang="en"><p>MD, senior lecturer of the Dept. of Pathology and Medical Jurisprudence, 2 Ostryakova Ave., Vladivostok, 690002;</p><p>pathologist, 4 Ostryakova Ave., Vladivostok, 690002</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9186-2914</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Назарова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nazarova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, врач,</p><p>690002, г. Владивосток, пр-т Острякова, 4</p></bio><bio xml:lang="en"><p>MD, PhD, </p><p>4 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">inazarova.cyto@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Резничек</surname><given-names>И. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Reznichek</surname><given-names>I. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студент,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>student, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">iliaone@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Туманина</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tumanina</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующая эндоскопическим отделением,</p><p>690105, г. Владивосток, ул. Русская, 59</p></bio><bio xml:lang="en"><p>MD, head of the Endoscopic Department, </p><p>59 Russkaya St., Vladivostok, 690105</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горелик</surname><given-names>М. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorelik</surname><given-names>M. Z.</given-names></name></name-alternatives><bio xml:lang="ru"><p>начальник,</p><p>690002, г. Владивосток, пр-т Острякова, 4</p></bio><bio xml:lang="en"><p>MD, head,</p><p>4 Ostryakova Ave., Vladivostok, 690002</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет;&#13;
Приморское краевое патологоанатомическое бюро</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University;&#13;
Primorkiy Regional Pathology Bureau</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Приморское краевое патологоанатомическое бюро</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Primorkiy Regional Pathology Bureau</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Приморский краевой онкологический диспансер</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Primorskiy Regional Oncological Dispensary</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2020</year></pub-date><volume>0</volume><issue>4</issue><fpage>90</fpage><lpage>92</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коцюрбий Е.А., Тихонов Я.Н., Назарова И.В., Резничек И.О., Туманина А.Н., Горелик М.З., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Коцюрбий Е.А., Тихонов Я.Н., Назарова И.В., Резничек И.О., Туманина А.Н., Горелик М.З.</copyright-holder><copyright-holder xml:lang="en">Kotsyrbiy E.A., Tychonov Y.N., Nazarova I.V., Reznichek I.O., Tumanina A.N., Gorelik M.Z.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/2133">https://www.tmj-vgmu.ru/jour/article/view/2133</self-uri><abstract><p>Проведен анализ жидкостного материала и  традиционных цитологических мазков, полученных при тонкоигольных биопсиях различных опухолей. Из жидкостного материала в зависимости от объема клеточных структур изготавливались клеточные блоки или монослойные препараты. При создании клеточных блоков для уплотнения и консолидации осадка после центрифугирования применялась оригинальная методика с использованием донорской тромбомассы. После 73 пункций образований поджелудочной железы, выполненных в различных медицинских учреждениях Владивостока в 2017–2019 гг., клеточные блоки удалось сформировать в 71 случае. Из них в 9 наблюдениях (12,7%) материал был признан диагностически неинформативным, в 15 (21,2%) – достаточным для морфологического исследования, но непригодным для иммуногистохимии. В 47 случаях (66,1%) выполнено 206 иммуногистохимических тестов с использованием 34 типов биомаркеров.</p></abstract><trans-abstract xml:lang="en"><p>Liquid-based material and traditional pap smears got during fine-needle biopsies of different tumors were analyzed. Cell-cycle blocks and monolayer pills were made from liquid-based material depending on the amount of cell structures. Original method using donor thrombocyte mass was implemented to create cell-cycle blocks, especially to condense and consolidate the sediment after centrifugation. After taking pancreas punctures different medical institutions in Vladivostok managed to form cell-cycle blocks in 71 cases from 2017 to 2019. In 9 cases (12.7%) the material was found to be diagnostically noninformative, in 15 cases (21.2%) – sufficient for morphological research, but inappropriate for immunohistochemistry. In 47 cases (66.1%) 206 immunohistochemical tests were made using 34 types of biomarkers.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>клеточный блок</kwd><kwd>жидкостная цитология</kwd><kwd>морфологическая диагностика</kwd><kwd>иммуногистохимия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cell block</kwd><kwd>liquid-based cytology</kwd><kwd>morphological diagnostics</kwd><kwd>immunohistochemistry</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Волченко Н.Н., Борисова О.В. Технология «клеточный блок» в цитологической практике. Новости клинической цитологии России. 2014;18(1–2);31–2.</mixed-citation><mixed-citation xml:lang="en">Volchenko NN, Borisova OV. Technology “Cell block” in the cytology practice. Russian News of Clinical Cytology. 2014;18(1–2):31–2 (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Волченко Н.Н., Савостикова М.В. Атлас цитологической и иммуноцитохимической диагностики опухолей. М.: Репроцентр М, 2010.</mixed-citation><mixed-citation xml:lang="en">Volchenko NN, Savostikova MV. Atlas of the cytological and immunohistochemical diagnostics of tumors. Moscow: Reprocentr M; 2010 (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Гилл Г.У. Клиническая цитология. Теория и практика цитотехнологии. М.: Практическая медицина, 2015.</mixed-citation><mixed-citation xml:lang="en">Gill GU. Clinical cytology. Theory and practices in cytotechnology. Moscow: Practical Medicine; 2015 (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Nazarova IV, Tychonov YN, Zdor VV. Optimization of the cytological diagnostics by the liquid-based cytology, cell block technique, and immunocytochemistry in the thyroid cytopathology. Acta Cytologica. 2016;60(S1):72. doi: 10.1159/000446388</mixed-citation><mixed-citation xml:lang="en">Nazarova IV, Tychonov YN, Zdor VV. Optimization of the cytological diagnostics by the liquid-based cytology, cell block technique, and immunocytochemistry in the thyroid cytopathology. Acta Cytologica. 2016;60(S1):72. doi: 10.1159/000446388</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Назарова И.В., Тихонов Я.Н., Здор В.В. Модифицированная методика изготовления клеточных блоков для повышения эффективности цитологической диагностики заболеваний щитовидной железы. Тихоокеанский мед. журнал. 2016;3(прил.):81.</mixed-citation><mixed-citation xml:lang="en">Nazarova IV, Tychonov YN, Zdor VV. Modified method of manufacturing cell blocks to increase the efficiency of cytological diagnosis of thyroid diseases. Pacific Medical Journal. 2016;3(S):81 (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hiroshima K, Di Wu, Hasegawa M, Ko E, Sekine Y, Ozaki D, et al. Utility of p16/CDKN2A FISH and BAP1 immunohistochemistry in distinguishing between mesothelioma and reactive mesothelial proliferation. Acta Cytologica. 2016;60(S1):27. doi: 10.1159/000446388</mixed-citation><mixed-citation xml:lang="en">Hiroshima K, Di Wu, Hasegawa M, Ko E, Sekine Y, Ozaki D, et al. Utility of p16/CDKN2A FISH and BAP1 immunohistochemistry in distinguishing between mesothelioma and reactive mesothelial proliferation. Acta Cytologica. 2016;60(S1):27. doi: 10.1159/000446388</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Dong-ge Liu. Cytology and molecular diagnosis in lung cancer. Acta Cytologica. 2016;60(S1):1. doi: 10.1159/000446388</mixed-citation><mixed-citation xml:lang="en">Dong-ge Liu. Cytology and molecular diagnosis in lung cancer. Acta Cytologica. 2016;60(S1):1. doi: 10.1159/000446388</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tamazyan N, Vorobyev S, Kostyuchek I, Protasov D, Petrunkin A. Effectiveness of the cell block technique in the diagnosis of metastatic effusions. Acta Cytologica. 2016;60(S1):70. doi: 10.1159/000446388</mixed-citation><mixed-citation xml:lang="en">Tamazyan N, Vorobyev S, Kostyuchek I, Protasov D, Petrunkin A. Effectiveness of the cell block technique in the diagnosis of metastatic effusions. Acta Cytologica. 2016;60(S1):70. doi: 10.1159/000446388</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
