<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34215/1609-1175-2021-1-37-41</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-2159</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>Значимость эпидемиологических факторов риска развития туберкулеза у детей и подростков в современных условиях</article-title><trans-title-group xml:lang="en"><trans-title>The significance of epidemiological risk factors for tuberculosis progression among children and teenagers under current conditions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попкова</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Popkova</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попкова Галина Георгиевна – кандидат медицинских наук, врач-фтизиатр.</p><p>127055, Москва, пл. Борьбы, 11/1</p></bio><bio xml:lang="en"><p>Galina G. Popkova, MD, PhD.</p><p>11/1 Borby Sq., Moscow, 127055</p></bio><email xlink:type="simple">galinapopkova@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смердин</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smerdin</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смердин Сергей Викторович – доктор медицинских наук, профессор, главный врач.</p><p>127055, Москва, пл. Борьбы, 11/1</p></bio><bio xml:lang="en"><p>Sergey V. Smerdin, MD, PhD, professor, chief physician.</p><p>11/1 Borby Sq., Moscow, 127055</p></bio><email xlink:type="simple">guz1980@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1687-7598</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плеханова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Plekhanova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плеханова Мария Александровна – доктор медицинских наук, доцент, заместитель главного врача по научно-клинической работе.</p><p>127055, Москва, пл. Борьбы, 11/1</p></bio><bio xml:lang="en"><p>Maria A. Plekhanova, MD, PhD, associate professor.</p><p>11/1 Borby Sq., Moscow, 127055</p></bio><email xlink:type="simple">dina-plus@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский областной клинический противотуберкулезный диспансер</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Clinical Tuberculosis Dispensary</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>21</day><month>03</month><year>2021</year></pub-date><volume>0</volume><issue>1</issue><fpage>37</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Попкова Г.Г., Смердин С.В., Плеханова М.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Попкова Г.Г., Смердин С.В., Плеханова М.А.</copyright-holder><copyright-holder xml:lang="en">Popkova G.G., Smerdin S.V., Plekhanova M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/2159">https://www.tmj-vgmu.ru/jour/article/view/2159</self-uri><abstract><sec><title>Цель</title><p>Цель: оценка эпидемиологических факторов риска развития туберкулеза у детей и подростков в современных условиях.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проанализированы эпидемиологические показатели по туберкулезу в Московской области за 2014-2019 гг. по основным формам федерального статистического наблюдения.</p></sec><sec><title>Результаты</title><p>Результаты. Среди детей и подростков Московской области отмечено снижение показателей заболеваемости туберкулезом. Увеличение охвата населения профилактическими осмотрами в 1,6 раза при выявлении туберкулеза позволило своевременно провести профилактические мероприятия и снизить заболеваемость детей и подростков, проживающих в бациллярных очагах в 11,8 раза. Повышение эффективности профилактических мероприятий обусловлено также внедрением пробы с туберкулезным рекомбинантным аллергеном, что увеличило приверженность родителей к профилактическому лечению детей и подростков до 92,9 %.</p></sec><sec><title>Заключение</title><p>Заключение. В условиях снижения заболеваемости туберкулезом сохранили значимость раннее и своевременное выявление этого заболевания и работа в очагах туберкулезной инфекции. Высокие риски развития туберкулеза у детей и подростков определяли контакты с бактериовыделителями и множественная лекарственная устойчивость микобактерий, а также наличие очага сформированного пациентами с ко-инфекцией ВИЧ+туберкулез.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: To estimate epidemiological factors of the tuberculosis progression among children and teenagers under current conditions.</p></sec><sec><title>Methods</title><p>Methods: Epidemiological indicators on tuberculosis in Moscow region for the period from 2014 to 2019 have been analyzed according to the forms of Federal Statistic Survey.</p></sec><sec><title>Results</title><p>Results: There is a decrease of tuberculosis disease rate in Moscow region among children and teenagers. The increase of preventive examination coverage by 1.6 times when tuberculosis was identified allowed to take timely preventive measures and to reduce the morbidity among children and adults living in the outbreaks of the infection by 11.8 times. The enhance of the effectiveness of preventive measures is due to the introduction of the sample of tuberculosis recombinant allergen. It increased the commitment of the parents to the preventive treatment of the children and teenagers up to 92.9 %.</p></sec><sec><title>Conclusions</title><p>Conclusions: Early and timely detection of tuberculosis and working in the outbreaks of tuberculosis infection preserve relevance under the conditions of tuberculosis disease. High risks of tuberculosis progression among children and adults defined contacts with a person discharging bacteria, also multiple drug resistance of the mycobacteria and the availability of the outbreak formed by patients having co-infection HIV+tuberculosis.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>подростки</kwd><kwd>очаг туберкулезной инфекции</kwd><kwd>профилактика</kwd><kwd>диагностика</kwd><kwd>Московская область</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>teenagers</kwd><kwd>outbreak of tuberculosis infection</kwd><kwd>prevention</kwd><kwd>diagnostics</kwd><kwd>Moscow region</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Global Tuberculosis Report 2016 [Electronic resource]. World Health Organization. Geneva: WHO Press; 2016. URL: https://www.afro.who.int/sites/default/files/2017-06/9789241565394-eng.pdf (Accessed 24 December 2020).</mixed-citation><mixed-citation xml:lang="en">Global Tuberculosis Report 2016 [Electronic resource]. World Health Organization. Geneva: WHO Press; 2016. URL: https://www.afro.who.int/sites/default/files/2017-06/9789241565394-eng.pdf (Accessed 24 December 2020).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Global tuberculosis Report 2017 [Electronic resource]. World Health Organization. Geneva: WHO Press; 2017. URL: https://reliefweb.int/sites/reliefweb.int/files/resources/9789241565516-eng.pdf (Accessed 24 December 2020).</mixed-citation><mixed-citation xml:lang="en">Global tuberculosis Report 2017 [Electronic resource]. World Health Organization. Geneva: WHO Press; 2017. URL: https://reliefweb.int/sites/reliefweb.int/files/resources/9789241565516-eng.pdf (Accessed 24 December 2020).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta N, Kumar R, Agrawal B. New payers in immunity to tuberculosis: The host microbiome, lung epithelium, and innate immune cells. Front Immunol. 2018;9:709.</mixed-citation><mixed-citation xml:lang="en">Gupta N, Kumar R, Agrawal B. New payers in immunity to tuberculosis: The host microbiome, lung epithelium, and innate immune cells. Front Immunol. 2018;9:709.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Floyd K, Glaziou P, Zumla A, Raviglione M. The global tuberculosis epidemic and progress in care, prevention, and research: An overview in year 3 of the End TB era. Lancet Respir Med. 2018;6(4):299-314.</mixed-citation><mixed-citation xml:lang="en">Floyd K, Glaziou P, Zumla A, Raviglione M. The global tuberculosis epidemic and progress in care, prevention, and research: An overview in year 3 of the End TB era. Lancet Respir Med. 2018;6(4):299-314.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Поддубная Л.В. Туберкулез у детей, его значение в оценке эпидемической ситуации по туберкулезу. Журнал клинической и экспериментальной медицины. 2005;156-65.</mixed-citation><mixed-citation xml:lang="en">Poddubnaya LV. Tuberkulez u detej, ego znachenie v otsenke epide-miologicheskoj situatsii po tuberkulezu. Zhurnal klinicheskoy i yeksperimentalnoy meditsiny. 2005;156-65 (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Мотанова Л.Н., Русских Н.Ю. Особенности клинического течения туберкулеза у детей и подростков из социально-дезадаптированных семей. Туберкулез и болезни легких. 2011;88(1):16-21.</mixed-citation><mixed-citation xml:lang="en">Motanova LN, Russkih NYu. The clinical features of tuberculosis in children and adolescents from socially disadapted families. Tuberculosis and Lung Diseases. 2011;88(1):16-21 (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Постановление Правительства РФ от 01.12.2004 г. № 715 «Об утверждении перечня социально значимых заболеваний и перечня заболеваний, представляющих опасность для окружающих». URL: http://www.referent.ru/1/68092 (Accessed 24 December 2020).</mixed-citation><mixed-citation xml:lang="en">Postanovlenie Pravitelstva RF ot 01.12.2004 g. No. 715 “Ob utverzhdenii perechnya social'no znachimyh zabolevanij i perechnya zabolevanij, predstavlyayushchih opasnost' dlya okruzhayushchih” (In Russ). URL: http://www.referent.ru/1/68092 (Accessed 24 December 2020).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Орел В.И., Кривохиж В.Н., Ким А.Г., Сокуров В.П. Медикосоциальная оценка здоровья детей с туберкулезной инфекцией. Вестник Педиатрической академии. 2005;3:101-5.</mixed-citation><mixed-citation xml:lang="en">Orel VI, Krivokhizh VN, Kim AG, Sokurov VP. Mediko-sotsi-alnaya otsenka zdorov'ya detej s tuberkuleznoj infekciey. Vestnik Pediatricheskoy Akademii. 2005;3:101-5 (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Walker V, Selby G, Wacogne I. Does neonatal BCG vaccination protect against tuberculous meningitis? Arch Dis Child. 2006;91(9):789-91.</mixed-citation><mixed-citation xml:lang="en">Walker V, Selby G, Wacogne I. Does neonatal BCG vaccination protect against tuberculous meningitis? Arch Dis Child. 2006;91(9):789-91.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Gideon HP, Flynn JL. Latent tuberculosis: What the host “sees”? Immunol Res. 2011;50(2-3):202-12.</mixed-citation><mixed-citation xml:lang="en">Gideon HP, Flynn JL. Latent tuberculosis: What the host “sees”? Immunol Res. 2011;50(2-3):202-12.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Шилова М.В. Туберкулез в России в 2012-2013 году. М., 2014.</mixed-citation><mixed-citation xml:lang="en">Шилова М.В. Туберкулез в России в 2012-2013 году. М., 2014. [Shilova MV. Tuberculosis in Russia in 2012-2013. Moscow; 2014 (In Russ).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
