pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.34215/1609-1175-2021-2-19-24pmj-2191Research ArticleОБЗОРЫREVIEWSДиагностика и контроль клеточного иммунитета пациентов с туберкулезомDiagnostics and control of cellular immunity of patients having tuberculosishttps://orcid.org/0000-0002-7822-2477КорсунскийИ. А.KorsunskiyI. A.

 д-р мед. наук, заведующий центром аллергологии и иммунологии

123317, г. Москва, Шмитовский пр-д, 29

 MD, PhD, head of the Center for Allergology and Immunology

20 Shmitovsky Pr., Moscow, 123317, Russian Federation 

iliakors@gmail.comhttps://orcid.org/0000-0003-1878-4467КудлайД. А.KudlayD. A.

д-р мед. наук, профессор кафедры фармакологии Института фармации; ведущий научный сотрудник лаборатории персонализированной медицины и молекулярной иммунологии № 71

119991, г. Москва, ул. Трубецкая, 8/2

115478, г. Москва, Каширское шоссе, 24

MD, PhD, professor of the Pharmacology Department; leading researcher of the Laboratory of Personalized Medicine and Molecular Immunology No. 71

8/2 Trubetskaya St., Moscow, 119991, Russian Federation

24 Kahirskoe Shosse, Moscow, 115478, Russian Federation

d624254@gmail.comДетская городская клиническая больница № 9 им. Г. Н. СперанскогоРоссияSperanskiy Children HospitalRussian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова; Государственный научный центр «Институт иммунологии» ФМБА РоссииРоссияSechenov First Moscow State Medical University; NRC Institute of Immunology FMBA of RussiaRussian Federation202120062021021924Copyright © Корсунский И.А., Кудлай Д.А., 20212021Корсунский И.А., Кудлай Д.А.Korsunskiy I.A., Kudlay D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/2191

 Туберкулез – одно из самых смертоносных и заразных заболеваний человека. Заболеваемость туберкулезом увеличилась из-за появления штаммов, устойчивых к лекарствам, и сочетания туберкулеза и ВИЧ. Последние технологические достижения, в том числе те, которые  используются для борьбы с туберкулезом, раздвинули границы  нашего понимания взаимодействия организма-хозяина и  патогена. Эта информация позволяет лучше понять, как  работает врожденный и адаптивный иммунитет при  туберкулезе. Появляется возможность разработать новые  методы лабораторной диагностики и наблюдения за больными  туберкулезом и больными с подозрением на туберкулез. В  обзоре представлены последние данные о функционировании иммунной системы при туберкулезе и новые подходы к  диагностике этого заболевания. 

 Tuberculosis is one of the most deadly and contagious diseases for people. Tuberculosis disease rate has increased because of the emergence of drug-resistant strains and HIV co-infection. Last technological achievements including those used to cure tuberculosis have extended our understanding of the interaction between the host organism and pathogen. This information allows getting a better understanding of how natural and adaptive immunities work in  the presence of tuberculosis. It gives an opportunity to develop new methods of  laboratory diagnostics and observe tuberculosis patients and patients having suspected tuberculosis. Latest research data on immune system functioning in case of tuberculosis and new approaches to diagnosing tuberculosis are presented in the survey. 

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The authors declare that there are no conflicts of interest present.