pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.34215/1609-1175-2021-2-25-30pmj-2192Research ArticleОБЗОРЫREVIEWSСердечная недостаточность: смена парадигмы о ведущих факторах риска и возможностях улучшения прогнозаHeart failure: A paradigm shift on the leading risk factors and opportunities for improving the prognosishttps://orcid.org/0000-0002-0117-0349НевзороваВ. А.NevzorovaV. A.

д-р мед. наук, профессор, директор Института терапии и инструментальной диагностики

690002, г. Владивосток, пр-т Острякова, 2

MD, PhD, professor, head of the Institute of Therapy

2 Ostryakova Ave., Vladivostok, 690002, Russian Federation

nevzorova@inbox.ruСелюковаП. А.SelyukovaP. A.

аспирант Института терапии и инструментальной диагностики 

690002, г. Владивосток, пр-т Острякова, 2

MD, post-graduate student of the Institute of Therapy and Instrumental Diagnostics

2 Ostryakova Ave, Vladivostok, 690002, Russian Federation

polina.selyukova@gmail.comhttps://orcid.org/0000-0002-6579-8936ПотаповаЕ. С.PotapovaE. S.

 канд. мед. наук, доцент Института терапии и инструментальной диагностики

690002, г. Владивосток, пр-т Острякова, 2

ORCID: ; e-mail: 

MD, PhD, associate professor, Institute of Therapy and Instrumental Diagnostics

2 Ostryakova Ave, Vladivostok, 690002, Russian Federation

virgo79@mail.ruТихоокеанский государственный медицинский университетРоссияPacific State Medical UniversityRussian Federation202120062021022530Copyright © Невзорова В.А., Селюкова П.А., Потапова Е.С., 20212021Невзорова В.А., Селюкова П.А., Потапова Е.С.Nevzorova V.A., Selyukova P.A., Potapova E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/2192

 Сердечная недостаточность (СН) остается актуальной проблемой современного общества в силу неуклонного роста, как ее распространенности, так и вклада в заболеваемость и смертность. Большинство пациентов с СН  имеют высокий индекс коморбидности. К одной из значимых и обсуждаемых позиций среди факторов риска и  заболеваний, вносящих весомый вклад в развитие СН,  относится сахарный диабет (СД). Существуют мнения о  важной роли СД в развитии сердечно-сосудистого ремоделирования при СН независимо от ее фенотипа, но  есть и альтернативные точки зрения, отрицающие самостоятельную роль СД как фактора риска СН.  Ингибиторы натрий-зависимых переносчиков глюкозы 2 типа, изначально позиционировавшиеся как средства  контроля гликемии, продемонстрировали  кардиопротективные эффекты и снижение риска развития СН у пациентов с СД и улучшения прогноза ее течения  независимо от наличия или отсутствия СД 2 типа. 

 Heart failure (HF) is still an urgent problem of the modern society due to constant growth of the both its spread rate and its influence on the disease and death rates. Most patients having HF have a high comorbidity index. Diabetes mellitus (DM) is considered to be one of the most significant and discussed risk factors and diseases influencing the development of HF. There are different opinions on the important role of DM in the development of cardiovascular remodeling in case of HF regardless its phenotype, but there are alternative points of view which refuse the independent role of DM as a  risk factor of HF. Inhibitors of type 2 glucose sodium-dependent cotransporters were originally positioned as a means to control glycaemia. They demonstrated cardio-protective effects and reduction of the risk of HF  development among patients having DM and better prognosis of the course of disease regardless presence or absence of the type 2 DM.  

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The authors declare that there are no conflicts of interest present.