pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.34215/1609-1175-2021-3-24-28pmj-2219Research ArticleОБЗОРЫREVIEWSАнтоцианы в практической медицинеAnthocyanins in practical medicinehttps://orcid.org/0000-0002-6206-200XКолдаевВ. М.KoldaevV. M.

д-р биол. наук, профессор, ведущий научный сотрудник лаборатории лекарственных растений,

690022, г. Владивосток, пр-т 100-летия Владивостока, 159

PhD, professor, leading researcher, 

159 100-letiya Vladivostoka Ave., Vladivostok, 690022

kolvm42@rambler.ruКропотовА. В.KropotovA. V.

д-р мед. наук, профессор кафедры общей и клинической фармакологии,

690002, г. Владивосток, пр-т Острякова, 2

MD, PhD, professor, Department of General and Clinical Pharmacology, 

2 Ostryakova Ave., Vladivostok, 690002

Федеральный научный центр биоразнообразия наземной биоты Восточной Азии Дальневосточного отделения Российской академии наукРоссияFederal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of SciencesRussian FederationТихоокенский государственный медицинский университетРоссияPacific State Medical UniversityRussian Federation202127092021032428Copyright © Колдаев В.М., Кропотов А.В., 20212021Колдаев В.М., Кропотов А.В.Koldaev V.M., Kropotov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/2219

Обзор публикаций о цитопротективных, антидиабетических, антимикробных, противоопухолевых и нейропротекторных свойствах гетероцикличных растительных гликозидов антоцианов, а также об использовании их для коррекции обменных процессов при ожирении. На основе анализа материалов публикаций можно заключить, что широкий спектр профилактических и лечебных эффектов этих гликозидов главным образом обусловлен их высокой антиоксидантной активностью, обеспечивающей инактивацию свободных радикалов, а также способностью модулировать внутриклеточные энергетические системы митохондрий. Устранение проявлений и  последствий окислительного стресса с  помощью антоцианов – перспективная стратегия нормализации метаболических нарушений при сердечно-сосудистой патологии. Высокая лабильность антоцианов ограничивает их использование в  пищевых и  медицинских продуктах, что относится к  сложным и  нерешенным пока проблемам. Исследования в  этой области в  первую очередь должны быть направлены на повышение устойчивости антоцианов, предотвращение их деградации при обработке и хранении растительного сырья. 

The survey of the publications on cytoprotective antidiabetic, antimicrobial, antitumor and neuroprotective effects of the heterocyclic plant anthocyan glycosides, and also on their use to adjust metabolic processes in case of obesity. Having analyzed of publications it was concluded that wide spectrum of preventive and therapeutic effects of these glycosides mainly depends on their high antioxidant activity. It provides inactivation of the free radicals and also the ability to modulate intracellular energy systems of the mitochondria. Elimination of the manifestation and consequences of the oxidative stress using anthocyans is a forward-looking strategy to normalize metabolic disorders in case of cardiovascular pathology. High lability of anthocyans limits their usage in food and medical products. It is considered to be a complex and unsolved problem. The research in this field should primarily be aimed at increasing anthocyans’ resistance and preventing their degradation during processing and storage of the plant material. 

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The authors declare that there are no conflicts of interest present.