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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34215/1609-1175-2021-3-45-48</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-2224</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>Вопросы унификации доклинической диагностики поражения миокарда у пациентов с сочетанной кардиореспираторной патологией</article-title><trans-title-group xml:lang="en"><trans-title>Questions of unification of preclinical diagnosis of myocardial damage among patients with combined cardiorespiratory pathology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7693-7404</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондрашова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kondrashova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач ВКБ № 1, 690078, г. Владивосток, ул. Садовая, 22;</p><p>ассистент Института терапии и инструментальной диагностики</p></bio><bio xml:lang="en"><p>MD, 22 Sadovaya St., Vladivostok, 690078;</p><p>assistant of the Institute of Therapy</p></bio><email xlink:type="simple">eak912@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0117-0349</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Невзорова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nevzorova</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, директор Института терапии и инструментальной диагностики,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>MD, PhD, professor, head of the Institute of Therapy, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">nevzorova@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондрашов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kondrashov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студент 6-го курса лечебного факультета,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>student, </p><p>92 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">oduvash111@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9348-3413</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шестакова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shestakova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доцент Института терапии и инструментальной диагностики,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>MD, PhD, associate professor, Institute of Therapy, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">shestakovanv@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Владивостокская клиническая больница №1;&#13;
Тихоокеанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vladivostok Clinical Hospital No. 1;&#13;
Pacific State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2021</year></pub-date><volume>0</volume><issue>3</issue><fpage>45</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кондрашова Е.А., Невзорова В.А., Кондрашов Д.В., Шестакова Н.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Кондрашова Е.А., Невзорова В.А., Кондрашов Д.В., Шестакова Н.В.</copyright-holder><copyright-holder xml:lang="en">Kondrashova E.A., Nevzorova V.A., Kondrashov D.V., Shestakova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/2224">https://www.tmj-vgmu.ru/jour/article/view/2224</self-uri><abstract><p>Цель – разработка способа диагностики раннего поражения левого желудочка (ЛЖ) сердца у курильщиков с ранними стадиями хронической обструктивной болезни легких (ХОБЛ) и артериальной гипертензии (АГ) методом спекл-трекинг эхокардиографии (ЭхоКГ) с применением новых индексов и возможностью их воспроизведения независимо от производителя ультразвукового сканера и его программного обеспечения.</p><sec><title>Материал и методы</title><p>Материал и методы. Обследованы 99 курильщиков, средний возраст 48,8 года. Пациенты были разделены на четыре группы в зависимости от наличия ХОБЛ и АГ. Выполнена стрейн-ЭхоКГ с оценкой локальной и продольной глобальной деформации ЛЖ.</p></sec><sec><title>Результаты</title><p>Результаты. Диастолическая дисфункция ЛЖ обнаружена во всех наблюдениях, но преобладала у пациентов с ХОБЛ и АГ. Глобальная и локальная продольная деформация ЛЖ была в пределах стандартных значений. Выявлено уменьшение деформации базальных сегментов ЛЖ среди пациентов с ХОБЛ и АГ, также средние значения деформации в базальных сегментах ЛЖ оказались меньше у пациентов с АГ независимо от наличия ХОБЛ.</p></sec><sec><title>Заключение</title><p>Заключение. Ранние признаки поражения миокарда ЛЖ у курильщиков более выражены на фоне ХОБЛ и АГ. Нормальные показатели стандартной ЭхоКГ, а также нормальные показатели глобальной и  локальной продольной деформации ЛЖ не исключают раннего повреждения миокарда. Относительные показатели продольной деформации ЛЖ  – более чувствительные маркеры поражения миокарда у  курильщиков на доклиническом этапе. Стрейн-ЭхоКГ может быть использована как аппаратно-независимый метод диагностики ранних признаков поражения миокарда ЛЖ. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: The development of the way of diagnosing early damage of left ventricle (LV) of heart among smokers with early stages of the chronic obstructive pulmonary disease (COPD) and arterial hypertension (AH) by speckle-tracking of echocardiography using new indexes and possibility of its reproduction regardless the manufacturer of ultrasound scanner and its software.</p></sec><sec><title>Methods</title><p>Methods: 99 smokers 48.8 years old on average were observed. Patients were divided into four groups depending on the presence of COPD and AH. Strain-echocardiography with the estimate of the local and left ventricular global longitudinal strain was performed.</p></sec><sec><title>Results</title><p>Results: Diastolic dysfunction of LV was defined during all observations, but it prevailed among patients having COPD and AH. Ventricular global and local longitudinal strains were within default values. The decrease in deformation of basal segments of LV among patients having COPD and AH was registered. Average value of the deformation in basal segments of LV turned out to be less among patients having AH regardless of existence of COPD.</p></sec><sec><title>Conclusions</title><p>Conclusions: Early signs of LV myocardial injuries among smokers are highly presented in case of COPD and AH. Both normal indexes of standard echocardiography and normal indexes of ventricular global and local longitudinal strains don’t exclude early myocardial damage. Relative indicators of ventricular longitudinal strains are more sensitive markers of myocardial damages among smokers in preclinical stage. Strain-echocardiography can be used as hardware-independent diagnostic method of the early signs of myocardial damage of LV. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>курильщики</kwd><kwd>стрейн-эхокардиография</kwd><kwd>продольная деформация миокарда</kwd><kwd>унифицированные индексы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>smokers</kwd><kwd>strain echocardiography</kwd><kwd>longitudinal myocardial deformation</kwd><kwd>unified indexes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Богданов Д.Ю., Кондрашова Е.А., Кулакова Н.В., Шестакова Н.В, Мокшина М.В., Мартыненко И.М. 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