pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.17238/PmJ1609-1175.2018.2.15-20pmj-227Research ArticleОБЗОРЫREVIEWSСемейство интерлейкина-17 при атопии и аллергических заболеванияхInterleukin-17 family in atopy and allergic diseasesПросековаЕ. В.ProsekovaE. V.pros.ev@mail.ruТурянскаяА. И.TuryanskayaA. I.noemail@neicon.ruДолгополовМ. С.DolgopolovM. S.noemail@neicon.ruТихоокеанский государственный медицинский университетРоссияPacific State Medical UniversityRussian Federation201828062018021520Copyright © Просекова Е.В., Турянская А.И., Долгополов М.С., 20182018Просекова Е.В., Турянская А.И., Долгополов М.С.Prosekova E.V., Turyanskaya A.I., Dolgopolov M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/227

Обзор представляет информацию об особенностях молекулярно-генетических механизмов и биологических эффектах представителей семейства интерлейкина-17 в иммунопатогенезе атопии и реализации аллергопатологии. Проведен анализ взаимосвязей интерлейкинов семейства 17 в системе цитокиновой регуляции инициации, развитии и течении аллергических заболеваний. Обсуждается значимость генетических предикторов и дисбаланса цитокинового профиля семейства интерлейкина-17 для прогноза реализации эндо- и фенотипических особенностей течения бронхиальной астмы, аллергического ринита и атопического дерматита.

The review provides the information about the features of molecular and genetic mechanisms and biological effects of Interleukin-17 family members in immunopathogenesis of atopy and design of allergic pathology. The correlation of Interleukin-17 family members in the system of cytokine initial regulation, development and course of allergic diseases was analyzed. The significance of genetic predictors and imbalance of cytokine profile of Interleukin-17 family is discussed to foresee the design of endo- and phenotypic features of the course of bronchial asthma, allergic rhinitis, and atopic dermatitis.

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The authors declare that there are no conflicts of interest present.