pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.17238/PmJ1609-1175.2018.2.21-25pmj-228Research ArticleОБЗОРЫREVIEWSМолекулы клеточной адгезии ICAM-1 и VCAM-1 при инфекционной патологииMolecules of cellular adhesion ICAM-1 and VCAM-1 in infectious pathologyМоскалецО. В.MoskaletsO. V.6816000@mail.ruМосковский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоРоссияMoscow Regional Scientific Research Clinical InstituteRussian Federation201828062018022125Copyright © Москалец О.В., 20182018Москалец О.В.Moskalets O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/228

Активация эндотелия - важное звено иммунного ответа на инфекцию. От состояния эндотелия зависят процессы миграции лейкоцитов в ткани из кровеносного русла. При активации эндотелия, сменяющейся затем его дисфункцией, происходит усиление экспрессии на мембране эндотелиальных клеток молекул клеточной адгезии, в частности молекулы межклеточной адгезии 1-го типа (intercellular adhesion molecule 1 - ICAM-1) и молекулы адгезии сосудистого эндотелия 1-го типа (vascular cell adhesion molecule 1 - VCAM-1), которые обеспечивают прочное прилипание лейкоцитов к эндотелию. Растворимые формы этих молекул можно рассматривать как суррогатные биомаркеры активации эндотелия. В обзоре приводятся данные мировой литературы об изменении экспрессии этих биомаркеров при сепсисе, гемолитико-уремическом синдроме, малярии, лихорадке денге, средиземноморской пятнистой лихорадке, вирусных гепатитах, туберкулезе. Несмотря на неоднозначные результаты исследований, можно сделать вывод, что ICAM-1 и VCAM-1 перспективны для дальнейшего изучения как в отношении прогнозирования течения и исходов при разной инфекционной патологии, так и для разработки новой терапевтической стратегии.

Endothelial activation is an important part of immune response to an infection. Processes of leukocytes migration in the tissue of blood vessels depend on endothelium condition. With the activation of the endothelium followed by its dysfunction, there is an increase in expression on the membrane of endothelial cells of molecules of cell adhesion, in particular, the molecule of intercellular adhesion molecule 1-type (ICAM-1) and the molecule of adhesion of vascular endothelium of the 1-type (vascular cell adhesion molecule 1 - VCAM-1), which provide a strong adhesion of leukocytes to the endothelium. Soluble forms of these molecules can be considered as surrogate biomarkers of endothelial activation. The review provides the data of the world literature of changes in the expression of these biomarkers in sepsis, hemolytic-uremic syndrome, malaria, dengue haemor-rhagic fever, boutonneuse fever, viral hepatitis, tuberculosis. Despite the ambiguous results it can be concluded that ICAM-1 и VCAM-1 are promising for further study both to foresee the course and outcomes in different infectious pathology, and to develop new therapeutic strategy.

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The authors declare that there are no conflicts of interest present.