pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.34215/1609-1175-2022-1-36-45pmj-2298Research ArticleОБЗОРЫREVIEWSРоль серотонина, ацетилхолина, оксида азота и FMRF-амида в адаптации морских гребешков к гипоксииThe role of serotonin, acetylcholine, nitric oxide and FMRF-amide in the adaptation of scallops to hypoxiahttps://orcid.org/0000-0003-0887-0257КоцюбаЕ. П.KotsyubaE. P.

Коцюба Елена Пантелеймоновна – старший научный сотрудник ННЦМБ ДВО РАН.

690041, Владивосток, ул. Пальчевского, 17

Kotsyuba Elena Panteleimonovna

17 Palchevsky str., Vladivostok, 690041

epkotsuba@mail.ruДячукВ. А.DyachukV. A.

Вячеслав Алексеевич Дячук - ННЦМБ ДВО РАН.

690041, Владивосток

Dyachuk Vyacheslav Alekseevich

Vladivostok 690041

Национальный научный центр морской биологии им. А.В. Жирмунского, Дальневосточное отделение Российской академии наук (ННЦМБ ДВО РАН)РоссияA.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of SciencesRussian Federation202226032022013645Copyright © Коцюба Е.П., Дячук В.А., 20222022Коцюба Е.П., Дячук В.А.Kotsyuba E.P., Dyachuk V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/2298

Проблема адаптации к кислородной недостаточности, ее роль в развитии заболеваний многие десятилетия изучается на моделях животных с разной устойчивостью к гипоксии. В данном обзоре обсуждаются данные литературы и результаты собственных исследований гормональных и медиаторных систем ЦНС, а также выяснение их роли в адаптивных физиологических и поведенческих реакциях у двустворчатых моллюсков. Анализ материалов по топографии серотонина (5-HT), ацетилхолина (ACh), оксида азота (NO) и FMRF-амид-содержащих нейронов в висцеральном ганглии и динамике их активности свидетельствует об участии нейротрансмиттеров и ферментов их синтеза в устойчивости  и пластичности нервной системы морских гребешков при гипоксии.

The problem of adaptation to oxygen deficiency and its role in the development of diseases have been studied for many decades on animal models having different level of resistance to hypoxia. This review discusses the literature data and the results of our own studies of hormonal and mediator systems of the central nervous system, as well as the clarification of their role in adaptive physiological and behavioral reactions in bivalves. The analysis of data on serotonin topography  (5-HT), acetylcholine (ACh), nitric oxide (NO) and FMRF-amide-containing neurons in the visceral ganglion and the dynamics of their activity provides evidence of the participation of neurotransmitters and enzymes of their synthesis in the stability and plasticity of the nervous system of scallops suffering hypoxia.

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The authors declare that there are no conflicts of interest present.