pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.34215/1609-1175-2022-1-65-71pmj-2301Research ArticleОБЗОРЫREVIEWSКаротиноиды в практической медицинеCarotenoids in practical medicinehttps://orcid.org/0000-0002-6206-200XКолдаевВ. М.KoldaevV. M.

Колдаев Владимир Михайлович - доктор биологических наук, профессор, ведущий научный сотрудник лаборатории лекарственных растений.

690022, Владивосток, проспект 100-летия Владивостока, 159

Vladimir M. Koldaev - Doctor of Biological Sciences, prof. Leading researcher, laboratory of medicinal plants, Federal scientific center of the East Asia terrestrial biodiversity.

690022, 159 Avenue of 100-years Vladivostok, Vladivostok 690022; 25-A, 27 Uborevich Ave. Vladivostok 690091; Tel.: +7(908)4487692

kolvm42@rambler.ruКропотовА. В.KropotovA. V.

Кропотов Александр Валентинович - доктор медицинских наук, профессор кафедры фармакологии.

690002, Владивосток, пр-т Острякова, 2; домашний адрес: 690048 Владивосток, ул. Невская, д. 33, кв. 135. Тел.: +7(914)6964607

Alexandr V. Kropotov - MD, phd, prof. Dept. of Pharmacology.

2 Ostryakova Ave. Vladivostok 690002. Home address: 33, 135 Nevskaya Ave. Vladivostok 690048. Tel.: +7(914)6964607

avkropotov2020@gmail.comФедеральный научный центр биоразнообразия наземной биоты Восточной Азии, Дальневосточное отделение Российской академии наукРоссияFederal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of SciencesRussian FederationТихоокенский государственный медицинский университетРоссияPacific State Medical UniversityRussian Federation202226032022016571Copyright © Колдаев В.М., Кропотов А.В., 20222022Колдаев В.М., Кропотов А.В.Koldaev V.M., Kropotov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/2301

В обзоре приводятся данные о применении каротиноидов при наиболее угрожающих патологических состояниях. Лечебно-профилактическое действие каротиноидов обусловлено инактивацией активных форм кислорода и свободных радикалов. Устраняя явления и последствия окислительного стресса, каротиноиды эффективны как в коррекции метаболических нарушений сахарного диабета и абдоминального ожирения, так и в снижении риска сердечно-сосудистых заболеваний. Обогащенные каротиноидами диеты проявляют широкий спектр противораковых эффектов, модуляций апоптоза и блокад метастазирования. Каротиноиды защищают от окислительных повреждений дофаминэргические нейроны головного мозга и снижают выраженность нейродегенеративных расстройств, болезней Альцгеймера и Паркинсона. Однако каротиноиды имеют ограниченную биодоступность из-за своей низкой водорастворимости. Будущие исследования должны быть направлены на разработку свободных от этого недостатка лекарственных форм каротинсодержащих фитопрепаратов.

The review presents data on the use of carotenoids in the most threatening pathological conditions. The therapeutic and preventive effect of carotenoids is due to the inactivation of active oxygen species and free radicals. By eliminating the phenomena and consequences of oxidative stress, carotenoids are effective both in treating metabolic disorders in diabetes mellitus and abdominal obesity, and in reducing the risk of cardiovascular diseases. Diets enriched with carotenoids have a wide range of anti-cancer effects, apoptosis modulations and metastasis blocks. Carotenoids protect dopaminergic neurons of the brain from oxidative damage and reduce the severity of neurodegenerative disorders, Alzheimer's and Parkinson's diseases. However, carotenoids have limited bioavailability due to their low water solubility. Future research should be directed to the development of medicinal forms of carotene-containing phytopreparations that don’t have such disadvantage.

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The authors declare that there are no conflicts of interest present.