pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.34215/1609-1175-2022-4-5-10pmj-2402Research ArticleОБЗОРЫREVIEWSАртериальная гипертензия и противоопухолевая лекарственная терапия: патофизиологические взаимосвязи и клиническое значениеArterial hypertension and anticancer drug therapy: pathophysiological relationships and clinical significancehttps://orcid.org/0000-0002-5192-4911СаталкинаТ. С.SatalkinaT. S.

Саталкина Татьяна Сергеевна – аспирант Департамента клинической медицины Школы медицины 

690922, г. Владивосток, о. Русский, п. Аякс, 10, Кампус ДВФУ, корпус М (25)

Tatyana S. Satalkina, postgraduate at the Department of Clinical Medicine 

690922, Vladivostok, Russian Island, 10 Ajax Bay, FEFU Campus, building М (25)

sts_sava1997@mail.ruБродскаяТ. А.BrodskayaT. A.

Владивосток

Vladivostok

ГельцерБ. И.GeltserB. I.

Владивосток

Vladivostok

Дальневосточный федеральный университетРоссияFar Eastern Federal UniversityRussian FederationДальневосточный федеральный университет; Тихоокеанский государственный медицинский университетРоссияFar Eastern Federal University; Pacific State Medical UniversityRussian Federation20221701202304510Copyright © Саталкина Т.С., Бродская Т.А., Гельцер Б.И., 20232023Саталкина Т.С., Бродская Т.А., Гельцер Б.И.Satalkina T.S., Brodskaya T.A., Geltser B.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/2402

Артериальная гипертензия (АГ) относится к наиболее частым кардиоваскулярным осложнениям противоопухолевой лекарственной терапии. В обзоре рассмотрены основные группы препаратов, индуцирующих развитие ятрогенной АГ при лечении злокачественных новообразований, патофизиологические механизмы повышения артериального давления (АД), а также клиническое значение развития АГ на фоне лечения цитостатиками и таргетными препаратами. Так, наиболее часто АГ регистрируется при применении ингибиторов ангиогенеза, а также алкилирующих цитостатиков, антиметаболитов, таксанов, ингибиторов протеасом. Кроме того, повышению АД могут способствовать эритропоэтины, глюкокортикостероиды и нестероидные противовоспалительные средства, применяемые в рамках симптоматической терапии. Контроль и своевременная коррекция АД у пациентов, получающих противоопухолевую лекарственную терапию, позволит в полном объеме осуществить программу лечения и улучшить их качество жизни. 

Arterial hypertension (AH) is one of the most common cardiovascular complications of anticancer drug therapy. In this review article, we consider the main groups of anticancer drugs that may cause the development of iatrogenic AH, the pathophysiological mechanisms of increased blood pressure, as well as the clinical significance of AH developed during treatment with cytostatics and targeted drugs in the practice of an oncologist and a cardiologist. It was found that AH is frequently associated with the use of angiogenesis inhibitors, as well as alkylating cytostatics, antimetabolites, taxanes, and proteasome inhibitors. In addition, erythropoietins, glucocorticosteroids, and non-steroidal anti-inflammatory drugs used as part of supportive therapy may contribute to an increase in blood pressure. Management of hypertension in cancer patients is an important part of antitumor treatment therapy whose implementation contributes to improving their quality of life. Research into various clinical and pathophysiological aspects of cardiovascular disorders in cancer patients is becoming increasingly relevant, which is indicated by the rapid development of cardio-oncology, a new interdisciplinary field of knowledge aimed at developing practical recommendations for the prevention, diagnosis, and treatment of cardiovascular toxicity caused by anticancer therapy.

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The authors declare that there are no conflicts of interest present.