pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.17238/PmJ1609-1175.2018.3.24-28pmj-252Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESКомплексное влияние медико-социальных и средовых факторов риска на вероятность развития колоректального ракаCOMPLEX IMPACT OF MEDICO-SOCIAL AND ENVIRONMENTAL RISK FACTORS ON PROBABILITY OF COLORECTAL CANCER DEVELOPMENTФельдблюмИ. В.FeldblyumI. V.epidperm@mail.ruАлыеваМ. Х.AlyevaM. H.noemail@neicon.ruРадионоваМ. В.RadionovaM. V.noemail@neicon.ruПермский государственный медицинский университет им. академика Е.А. ВагнераРоссияPerm State Medical University named after Academician E.A. WagnerRussian FederationНациональный исследовательский университет «Высшая школа экономики»РоссияNational Research University Higher School of EconomicsRussian Federation201828092018032428Copyright © Фельдблюм И.В., Алыева М.Х., Радионова М.В., 20182018Фельдблюм И.В., Алыева М.Х., Радионова М.В.Feldblyum I.V., Alyeva M.H., Radionova M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/252

Представлены результаты аналитического эпидемиологического исследования «случай-контроль» по изучению комплексного влияния медико-социальных и средовых факторов риска на вероятность развития колоректального рака (КРР). Группу «случай» составили 204 пациента с гистологически верифицированным КРР, контрольную - 205 человек, у которых КРР был исключен по результатам колоноскопии. Построены logit-модели вероятности развития опухоли в зависимости от влияния медико-социальных и средовых факторов. Установлено, что заболеваемость КРР среди населения Пермского края в целом детерминирована исследованными факторами на 56,4 % (мужчин - на 39,26 %, женщин - на 48,36 %). Наибольшее значение при сочетанном воздействии имели такие факторы, как полипоз толстой кишки, употребление острой пищи, нерегулярное прохождение профилактических медицинских осмотров и длительность запоров.

Objective. We analyzed the complex impact of medico-social and environmental risk factors on probability of colorectal cancer development. Methods. The epidemiological analytical sampling analysis 'case-control' was carried out. The group 'case' included 204 patients with colorectal cancer (79 patients with colon cancer, 125 -with rectum cancer). The medico-social and environmental risk factors were assessed with survey questionnaire (patterned interview). Results. A binary choice model shows that the most significant factors, increasing the probability of colorectal cancer development with combined impact on population, were spicy food intake, polyposis of large intestine, duration of constipation; factors decreasing the probability of colorectal cancer were boiled tap water intake and frequent medical examinations. At the 5 % level, factors such as age, the presence of precancerous diseases and relatives of the 1st and/or 2nd degree of kinship with malignant neoplasms of the gastrointestinal tract or the reproductive system demonstrated significance. With an increase in age by one year, the probability of developing colorectal cancer increased by 1.5 %. The total results of the combined impact of studied factors showed that the incidence of colorectal cancer by 56.4 % was determined by above-mentioned risk factors. Conclusions. Determined associations of medico-social and environmental factors require in-depth study to identify additional risk factors and their interactions with genetic determinants in order to develop a primary prevention system of colorectal cancer.

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The authors declare that there are no conflicts of interest present.