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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34215/1609-1175-2023-2-65-68</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-2520</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>Особенности регионального кровотока у лиц молодого возраста на фоне витамин В12-дефицитной анемии</article-title><trans-title-group xml:lang="en"><trans-title>Features of regional blood flow in young people with vitamin B12 deficiency anemia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жекотов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhekotov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5830-1322</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котельников</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotelnikov</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Котельников Владимир Николаевич – доктор медицинских наук, профессор, заведующий кафедрой медицины катастроф и безопасности жизнедеятельности Тихоокеанского МУ; профессор департамента клинической медицины Школы медицины ДФУ.</p><p>690002, Владивосток, пр-т Острякова, 2; 690922, Приморский край, Владивосток, о. Русский, п. Аякс, 10</p></bio><bio xml:lang="en"><p>Vladimir N. Kotelnikov - Dr. Sci. (Med.), Professor. Head of the Chair of Disaster Medicine and Life Safety of the Pacific MU; Prof. of the Department of Clinical Medicine, School of Medicine of the Far Eastern FU.</p><p>2 Ostryakova Ave., Vladivostok, 690002; 10, Ajax, Russian Island, Vladivostok, 690922</p></bio><email xlink:type="simple">671235@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гельцер</surname><given-names>Б. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Geltser</surname><given-names>B. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попов</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Popov</surname><given-names>A. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет; Дальневосточный филиал Государственного научно-исследовательского испытательного института военной медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University; Far Eastern Branch of the State Research and Testing Institute of Military Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Дальневосточный федеральный университет, Школа медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Far Eastern Federal University, School of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>14</day><month>06</month><year>2023</year></pub-date><volume>0</volume><issue>2</issue><fpage>65</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Жекотов А.Н., Котельников В.Н., Гельцер Б.И., Попов А.Ф., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Жекотов А.Н., Котельников В.Н., Гельцер Б.И., Попов А.Ф.</copyright-holder><copyright-holder xml:lang="en">Zhekotov A.N., Kotelnikov V.N., Geltser B.I., Popov A.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/2520">https://www.tmj-vgmu.ru/jour/article/view/2520</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: выявление особенностей регионального кровотока в печени кровотока у лиц молодого возраста на фоне витамин В12-дефицитной анемии (ВБДА).</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Обследованы 64 пациента в возрасте с медианой 38 лет и 95% доверительным интервалом [26; 49], с диагностированной ВБДА. Оценивали показатели гемодинамики печени и центрального кровообращения при УЗИ допплерографическим методом в импульсно-волновом режиме, цветового и энергетического картирования. Статистическая обработка данных проводилась с использованием программы Statistica 25,0.</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что нарушения гемодинамики при ВБДА в дебюте заболевания прежде всего ассоциируются со снижением на 13,8% соотношения линейной скорости портального потока и диаметра воротной вены и как следствие «застоя» крови в печени. У лиц с длительным анамнезом ВБДА выявлено вовлечение венозного коллектора печеночной гемодинамики и снижение объёмных величин (16,8%) на фоне повышенного периферического тонуса печеночных сосудов (23,5%). Выявлена корреляционная зависимость показателей регионального кровотока в печени от типа центральной гемодинамики наиболее выраженная при тяжелой ВБДА и гипокинетическим типом.</p></sec><sec><title>Заключение</title><p>Заключение. Оценка регионального кровотока печени является эффективным методом диагностики состояния органовмишеней при ВБДА и является информативным инструментом для верификации предикторов и прогнозирования тяжести данной патологии.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To investigate specific features of regional blood flow in the liver of young people with vitamin B12 deficiency anemia (VBDA).</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A total of 64 patients diagnosed with VBDA with the median age of 38 years and 95% confidence interval [26; 49] were examined. Hemodynamic parameters of the liver and central circulation were assessed using pulsedwave Doppler ultrasound with color and power imaging. Statistical data was processed by Statistica 25.0.</p></sec><sec><title>Results</title><p>Results. At the onset of VBDA, the revealed hemodynamic disorders are primarily associated with a 13.8% decrease in the ratio of the linear velocity of the portal flow and the diameter of the portal vein, which leads to liver blood stagnation. A long medical history of VBDA is associated with the venous collector of hepatic hemodynamics and a decrease in the volume values (16.8%) against the background of increased peripheral vascular tone of hepatic vessels (23.5%). A correlation between the indicators of regional blood flow in the liver and the type of central hemodynamics was revealed, being most pronounced in severe VBDA and the hypokinetic hemodynamics type.</p></sec><sec><title>Conclusion</title><p>Conclusion. Assessment of the regional blood flow of the liver was found to be an effective method for diagnosing the state of target organs in VBDA and for verifying the predictors of VBDA severity.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>гемодинамика печени</kwd><kwd>витамин В12-дефицитная анемия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver hemodynamics</kwd><kwd>vitamin B12 deficiency anemia</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">работа выполнена при частичной финансовой поддержке гранта РФФИ в рамках научного проекта 18-29-03131</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gao X, Lindqvist A, Sandberg M, Groop L, Wierup N, Jansson L. Effects of GIP on regional blood flow during normoglycemia and hyperglycemia in anesthetized rats. 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