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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34215/1609-1175-2023-4-69-71</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-2604</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>Анализ клинических случаев прогрессирования диабетической ретинопатии у беременных c сахарным диабетом 1-го типа</article-title><trans-title-group xml:lang="en"><trans-title>Аnalysis of clinical cases of diabetic retinopathy progression in pregnant women with type 1 diabetes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3757-8351</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Помыткина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pomytkina</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Помыткина Наталья Викторовна – канд. мед. наук, врач-офтальмолог отделения лазерной хирургии Хабаровского филиала МНТК «“Микрохирургия глаза” им. акад. С.Н. Федорова» Минздрава России</p><p>680033, г. Хабаровск, ул. Тихоокеанская, 211</p><p>тел.: +7 (421) 290-56-17</p></bio><bio xml:lang="en"><p>Natalia V. Pomytkina, Cand. Sci. (Med.), ophthalmologist of the Department of Laser Surgery Fyodorov Eye Microsurgery Federal State Institution</p><p>211 Tikhookeanskaya str., Khabarovsk, 680033</p><p>phone: +7 (421) 290-56-17</p></bio><email xlink:type="simple">naukakhvmntk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>МНТК «“Микрохирургия глаза” им. акад. С.Н. Федорова» Минздрава России, Хабаровский филиал; Дальневосточный государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch; Far Eastern State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>02</day><month>02</month><year>2024</year></pub-date><volume>0</volume><issue>4</issue><fpage>69</fpage><lpage>71</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Помыткина Н.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Помыткина Н.В.</copyright-holder><copyright-holder xml:lang="en">Pomytkina N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/2604">https://www.tmj-vgmu.ru/jour/article/view/2604</self-uri><abstract><p>Представлены клинические случаи прогрессирования диабетической ретинопатии (ДР) у беременных с сахарным диабетом 1-го типа. При манифестации препролиферативной ДР установлено формирование фокального макулярного отека обоих глаз, с зонами неперфузии перимакулярной локализации. На обоих глазах проведена лазеркоагуляция сетчатки. Через 1 месяц обнаружен регресс макулярного отека на левом глазу и геморрагических явлений на обоих глазах, но с появлением новых зон неперфузии. Прогрессирование ДР во время беременности и в послеродовом периоде определяется рядом факторов: компенсацией сахарного диабета, стабилизацией ретинопатии, наличием сопутствующей патологии. При агрессивном течении пролиферативной ДР выявлена локальная тракционная отслойка сетчатки, частичный гемофтальм левого глаза. Проведены 3 этапа панретинальной лазеркоагуляции обоих глаз, эндовитреальное вмешательство с силиконовой тампонадой на левом глазу. В 28 недель беременности на правом глазу наблюдалось прогрессирование ретинальной неоваскуляризации, обширные зоны неперфузии в заднем полюсе. Проведено уплотнение зон лазеркоагуляции сетчатки на правом глазу.</p></abstract><trans-abstract xml:lang="en"><p>This paper presents clinical cases of diabetic retinopathy (DR) progression in pregnant women with type 1 diabetes. In preproliferative DR, the formation of focal macular edema in both eyes with nonperfusion areas of perimacular localization was observed. Both eyes were subjected to laser coagulation of the retina. After one month, a regression of macular edema in the left eye and hemorrhagic phenomena in both eyes was established with the emergence of new nonperfusion zones. DR progression during pregnancy and in the postpartum period is determined by a number of factors, including diabetes mellitus compensation, retinopathy stabilization, and the presence of concomitant pathologies. In the aggressive course of proliferative DR, local traction retinal detachment and partial hemophthalmos of the left eye were revealed. In this case, three stages of panretinal laser coagulation of both eyes and endovitreal intervention with silicone tamponade on the left eye were performed. At 28 weeks of gestation, progression of retinal neovascularization was observed in the right eye, extensive areas of nonperfusion in the posterior pole. The areas of laser coagulation of the retina were compacted in the right eye.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>беременность</kwd><kwd>прогрессирование диабетической ретинопатии</kwd><kwd>лазеркоагуляция сетчатки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>diabetic retinopathy progression</kwd><kwd>retinal laser photocoagulation</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Автор заявляет о финансировании проведенного исследования из собственных средств.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chew EY, Mills JL, Metzger BE, Remaley NA, Jovanovic-Peterson L, Knopp RH, Conley M, Rand L, Simpson JL, Holmes LB, Aarons JH. Metabolic control and progression of retinopathy. The diabetes in early pregnancy study. 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