pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.34215/1609-1175-2024-1-5-10pmj-2681Research ArticleПЕРЕДОВАЯ СТАТЬЯEDITORIALСравнительная характеристика генотипов интерлейкинов и риски реализации фенотипов бронхиальной астмы у детейComparative characterization of interleukin genotypes and risks of bronchial asthma phenotypes in childrenШуматовВ. Б.ShumatovV. B.

Владивосток

Vladivostok 

https://orcid.org/0000-0001-6632-9800ПросековаЕ. В.ProsekovaE. V.

Просекова Елена Викторовна – д-р мед. наук, профессор, заведующий кафедрой клинической лабораторной диагностики, общей и клинической иммунологии

тел.: +7 (908) 993-09-04 

69002, г. Владивосток, пр-т Острякова, 2 

Elena V. Prosekova, Dr. Sci. (Med.), Full Professor, Head of Department of Clinical Laboratory Diagnostics and General and Clinical Immunology

2 Ostryakova Ave, Vladivostok, 690002 

pros.ev@mail.ruДолгополовМ. С.DolgopolovM. S.

Владивосток 

Vladivostok 

ТурянскаяА. И.TuryanskayaA. I.

Владивосток 

Vladivostok 

КовальчукВ. К.KovalchukV. K.

Владивосток 

Vladivostok 

СабынычВ. А.SabynychV. A.

Владивосток 

Vladivostok 

Тихоокеанский государственный медицинский университетPacific State Medical UniversityRussian Federation20241805202401510Copyright © Шуматов В.Б., Просекова Е.В., Долгополов М.С., Турянская А.И., Ковальчук В.К., Сабыныч В.А., 20242024Шуматов В.Б., Просекова Е.В., Долгополов М.С., Турянская А.И., Ковальчук В.К., Сабыныч В.А.Shumatov V.B., Prosekova E.V., Dolgopolov M.S., Turyanskaya A.I., Kovalchuk V.K., Sabynych V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/2681

В статье представлен анализ генетических предикторов развития различных эндотипических и фенотипических вариантов бронхиальной астмы у детей. Обзор данных по структуре и встречаемости однонуклеотидных полиморфизмов генов интерлейкинов показывает их взаимосвязь с риском реализации вирус-индуцированного и аллерген-индуцированного фенотипов бронхиальной астмы. Значимые различия генотипов коррелируют с аберрантной продукцией интерлейкинов и с шансами развития разных фенотипов заболевания. Исследования генетических факторов предоставляет информацию о значимости функциональных полиморфизмов генов интерлейкинов как предикторов, ассоциированных с риском развития и фенотипическими особенностями заболевания.

The present paper analyses genetic predictors of various endotypes and phenotypes of bronchial asthma in children. The review of data on the structure and prevalence of single-nucleotide polymorphisms of interleukin genes demonstrates their correlation with the risk of virus-induced and allergen-induced phenotypes of bronchial asthma. Significant differences in genotypes correlate with aberrant production of interleukin and the risks for developing various phenotypes of the disease. The studies into genetic factors indicate the significance of functional polymorphisms of interleukin genes as predictors associated with phenotypes and risk of the disease.

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The authors declare that there are no conflicts of interest present.