pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.34215/1609-1175-2024-1-43-47pmj-2688Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESStenotrophomonas maltophilia как возбудитель имплантат-ассоциированной инфекции у пациентов травматолого-ортопедического профиляStenotrophomonas maltophilia as a causative agent of implant-associated infection in trauma and orthopedic patientshttps://orcid.org/0000-0003-2326-7413ГординаЕ. М.GordinaE. M.

Гордина Екатерина Михайловна – канд. мед. наук, старший научный сотрудник отделения профилактики и лечения раневой инфекции

195427, г. Санкт-Петербург, ул. Академика Байкова, 8 

Ekaterina M. Gordina, Cand. Sci. (Med.), senior researcher of the division of wound infection treatment and prevention 

8, Akademika Baykova street, St. Petersburg, 195427 

emgordina@win.rniito.ruБожковаС. А.BozhkovaS. A.

Санкт-Петербург 

St. Petersburg 

РукинаА. Н.RukinaA. N.

Санкт-Петербург 

St. Petersburg 

Национальный медицинский исследовательский центр травматологии и ортопедии им. Р.Р. ВреденаРоссияVreden National Medical Research Center of Traumatology and OrthopedicsRussian Federation202418052024014347Copyright © Гордина Е.М., Божкова С.А., Рукина А.Н., 20242024Гордина Е.М., Божкова С.А., Рукина А.Н.Gordina E.M., Bozhkova S.A., Rukina A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/2688

Цель: оценка этиологической значимости S. maltophilia в развитии ортопедической имплантат-ассоциированной инфекции. Материалы и методы. Выполнен ретроспективный анализ частоты выделения S. maltophilia от пациентов с перипротезной инфекцией и остеомиелитом c 2005 по 2020 г. с применением программы «Микроб-2». Выделение клинических изолятов проводили в соответствии со стандартными методиками. Идентификацию осуществляли на панелях Microlatest с помощью iEMS Reader MF. Антибиотикочувствительность культур изучали в соответствии с требованиями EUCAST. Результаты. За 16 лет идентифицировано 69 штаммов S. maltophilia – 0,33% от всех выделенных возбудителей (n = 20 631). В 50% случаев изолировали из тканевых биоптатов, в 30% – в раневом отделяемом. В 89% S. Maltophilia выделяли в микробных ассоциациях, в том числе в 65% случаев совместно с грамположительными бактериями, в 18% – с другими неферментирующими грамотрицательными бактериями и в 6% – с другими патогенами. К триметоприму/ сульфаметоксазолу были чувствительны 63%, устойчивы – 25,5% изолятов. Установлено увеличение доли чувствительных культур к данному препарату с 63% в 2011–2014 гг. до 81% в 2015–2019 гг. (р = 0,08). Заключение. S. maltophilia необходимо рассматривать как возможный этиологический агент, способный вызывать тяжелые хронические ортопедические инфекции.

Objective. To evaluate an etiologic significance of S. maltophilia in the development of orthopedic implant-associated infections. Materials and methods. The study involved a retrospective analysis of the frequency of excretion of S. maltophilia in patients with periprosthetic infection and osteomyelitis, using the Microbe-2 program in period of 2005–2020. Clinical isolates were excreted according to standard methods. Identification was performed via Microlatest panels using iEMS Reader MF. Antibiotic susceptibility was studied in accordance with EUCAST. Results. Over 16 years 69 strains of S. maltophilia have been identified, comprising 0.33% of all isolated pathogens (n=20631). 50% of isolates were excreted from tissue biopsies, 30% – from wound exudates. In 89% of cases, S. maltophilia was isolated in microbial associations, including 65% of cases together with Grampositive bacteria, 18% with other non-fermenting Gram-negative bacteria, and 6% with other pathogens. 63% appeared sensitive to trimethoprim/sulfamethoxazole and 25.5% of isolates were resistant. The proportion of cultures sensitive to this drug was found to increase from 63% in 2011–2014 to 81% in 2015–2019 (p = 0.08). Conclusion. S. maltophilia should be considered as a causative etiologic agent of severe chronic orthopedic infections.

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The authors declare that there are no conflicts of interest present.