pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.34215/1609-1175-2024-1-48-52pmj-2689Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESГенетические маркеры эндотелиальной дисфункции при хронической обструктивной болезни легкихGenetic markers of endothelial dysfunction in chronic obstructive pulmonary diseasehttps://orcid.org/0000-0002-6902-7784ДаушеваА. Х.DaushevaA. Kh.

Даушева Айсылу Хаировна – канд. мед. наук, доцент кафедры внутренних болезней, врач 

443001, г. Самара, ул. Чапаевская, 227 

Aisylu Kh. Dausheva, Cand. Sci. (Med.), Associate Professor of the Department of Internal Medicine, doctor  

227 Chapayevskaya street, Samara, 443001 

daushevaah@mail.ruЗарубинаЕ. Г.ZarubinaE. G.

Самара

Samara

БогдановаЮ. В.BogdanovaYu. V.

Самара

Samara 

Медицинский университет «Реавиз» ; Самарская областная клиническая больница им. В.Д. СередавинаРоссияMedical University “Reaviz” ; Samara Regional Clinical Hospital named after V.D. Seredavin (Public Funded Health Facility Samara Regional Clinical Hospital after V.D. Seredavin)Russian FederationМедицинский университет «Реавиз»РоссияMedical University “Reaviz”Russian FederationСамарская областная клиническая больница им. В.Д. СередавинаРоссияSamara Regional Clinical Hospital named after V.D. Seredavin (Public Funded Health Facility Samara Regional Clinical Hospital after V.D. Seredavin)Russian Federation202418052024014852Copyright © Даушева А.Х., Зарубина Е.Г., Богданова Ю.В., 20242024Даушева А.Х., Зарубина Е.Г., Богданова Ю.В.Dausheva A.K., Zarubina E.G., Bogdanova Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/2689

Цель: анализ генетических маркеров дисфункции эндотелия при хронической обструктивной болезни легких. Материалы и методы. Обследовано 285 пациентов с хронической обструктивной болезнью легких в возрасте 67,12 ± 1,82 года, в гендерном соотношении 73,68% мужчин и 26,32% женщин. 70 респондентов составили группу контроля, из них 45 практически здоровых людей, из них 64,3% мужчин и 35,7% женщин. Методом ПЦР исследованы полиморфизмы генов эндотелиальной синтазы оксида азота NOS3 (C786T), эндотелина-1 EDN1 Lys198Asn. Результаты. В когорте пациентов ХОБЛ отмечено преобладание патологического гомозиготного генотипа 786СС NOS3 (χ2 = 12,84, df = 1, p = 0,0003). Носительство гетерозиготного варианта LysAsn полиморфного маркера Lys198Asn гена EDN1 у пациентов ХОБЛ выявлено в 32,5%. Заключение. Манифестация эндотелиальной дисфункции у пациентов ХОБЛ обусловлена генотипической предрасположенностью, ассоциированной с носительством полиморфизмов 786СС гена NOS3 (OR 7,01, 95% ДИ 1,59–30,81) и Lys198Asn гена EDN1 (OR 2,53, 95% ДИ 0,69–9,22).

Objective. To analyze genetic markers of endothelial dysfunction in chronic obstructive pulmonary disease. Materials and methods. The study involved an examination of 285 patients with chronic obstructive pulmonary disease aged 67.12 ± 1.82, including males (73.68%) and females (26.32%). A control group consisted of 70 respondents, including 45 relatively healthy people, among whom males constituted 64.3% and females 35.7%. Polymorphisms of endothelial nitric oxide synthase NOS3 (C786T), endothelin-1 EDN1 Lys198Asn genes were examined by PCR method. Results. The cohort of COPD patients revealed a prevalence of pathological homozygous genotype 786SS NOS3 (χ2=12.84, df=1, p=0.0003). Carriage of heterozygous variant of LysAsn polymorphic marker Lys198Asn of EDN1 gene in COPD patients was detected in 32.5%. Conclusion. Manifestation of endothelial dysfunction in COPD patients is due to genotypic predisposition associated with carrying polymorphisms 786SS of NOS3 gene (OR 7.01, 95% CI 1.59-30.81) and Lys198Asn of EDN1 gene (OR 2.53, 95% CI 0.69-9.22)

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The authors declare that there are no conflicts of interest present.