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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34215/1609-1175-2024-2-55-59</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-2731</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>Анализ устойчивости бактерий рода Enterococcus к антибиотикам</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of antibiotic resistance in Enterococcus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6823-5971</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мартынова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Martynova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мартынова Алина Викторовна – д-р мед. наук, профессор кафедры эпидемиологии и военной эпидемиологии; профессор кафедры биоразнообразия и морских биоресурсов </p><p>690922, г. Владивосток, о. Русский, п. Аякс, 10</p><p>+7 (914) 701-69-08</p></bio><bio xml:lang="en"><p>Alina V. Martynova, Dr. Sci. (Med.), Professor of the Epidemiology Department; Professor of the Department of Biodiversity and Marine Bioresources</p><p>2 Ostryakova Ave, Vladivostok, 690002</p></bio><email xlink:type="simple">clinmicro@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ускова</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Uskova</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет; Дальневосточный федеральный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University; Far Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Дальневосточный федеральный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Far Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>02</day><month>08</month><year>2024</year></pub-date><volume>0</volume><issue>2</issue><fpage>55</fpage><lpage>59</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мартынова А.В., Ускова С.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Мартынова А.В., Ускова С.С.</copyright-holder><copyright-holder xml:lang="en">Martynova A.V., Uskova S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/2731">https://www.tmj-vgmu.ru/jour/article/view/2731</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучить влияние антибактериальных веществ на бактерии рода Enterococcus, выделенных из водной среды с антропогенной нагрузкой.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Исследование 61 штамма рода Enterococcus, выделенных в водных пробах реки Вторая речка, полученных на территории г. Владивостока, производилось в период с 17 января 2018 г. по 27 сентября 2020 г. Устойчивость к антибиотикам изучалась при помощи диско-диффузионного метода. Статистическая обработка данных производилась в программе Statistica 10. Графики формировались в программе Excel 10.</p></sec><sec><title>Результаты</title><p>Результаты. Исследование чувствительности 61 штамма рода Enterococcus к антибиотикам показало, что большинство штаммов были резистентными к стрептомицину 66% (n = 40), к эритромицину 56% (n = 33) промежуточно устойчивых штаммов, к рифампицину было обнаружено 72% (n = 44) резистентных штаммов, к гентамицину – 87% (n = 52) чувствительных штаммов, а к ванкомицину – 25% (n = 15) промежуточно устойчивых и 3% (n = 2) резистентных изолятов.</p></sec><sec><title>Заключение</title><p>Заключение. Изучение антибиотикорезистентности у штаммов рода Еnterococcus выделенных из р. Вторая Речка, показало повышенный уровень устойчивых к рифампицину и стрептомицину штаммов. Выделенная в р. Вторая Речка популяция штаммов энтерококков характеризовалась резистентностью к двум антибиотикам 41% (n = 25), однако один штамм обладает полирезистентностью к шести антибиотикам. Чаще всего встречалась резистентность к сочетанию таких антибиотиков, как стрептомицин, рифампицин и эритромицин.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To study the effect of antibacterial substances on bacteria Enterococcus isolated from the aquatic environment with anthropogenic load. </p></sec><sec><title>Materials and methods</title><p>Materials and methods. Study of 61 strains of Enterococcus isolated from water samples of the Vtoraya Rechka river, the Vladivostok territory, was conducted in the period from January 17, 2018 to September 27, 2020. The antibiotic resistance was determined using the disc diffusion test. Statistical data processing was carried out by the Statistica 10 program. Graphs were performed in Excel 10.</p></sec><sec><title>Results</title><p>Results. The study into susceptibility of 61 strains of Enterococcus to antibiotics revealed the majority of resistant strains to streptomycin (66%, n=40), 56% (n=33) intermediate strains to erythromycin, 72% (n=44) resistant strains to rifampicin, 87% (n=52) susceptible strains to gentamicin, 25% (n=15) intermediate resistant isolates, and 3% (n=2) resistant isolates.</p></sec><sec><title>Conclusion</title><p>Conclusion. The study of antibiotic resistance in strains of Еnterococcus isolated from the Vtoraya Rechka river showed high levels of rifampicin and streptomycin resistant strains. The population of enterococci strains isolated from the Vtoraya Rechka river appeared 41%-resistant to two antibiotics (n=25), however, one strain proved multidrug resistance to six antibiotics. Resistance to a combination of streptomycin, rifampicin, and erythromycin antibiotics was most commonly detected.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>Enterococcus</kwd><kwd>антибиотики</kwd><kwd>полирезистентность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Enterococcus</kwd><kwd>antibiotics</kwd><kwd>multidrug resistance</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Красная Ю.В., Нестеров А.С., Потатуркина-Нестерова Н.И. Значение бактерий рода Enterococcus в жизнедеятельности человека. Современные проблемы науки и образования. 2014;(3):1169–78</mixed-citation><mixed-citation xml:lang="en">Krasnaya YuV, Nesterov AS, PotaturkinaNesterova NI. Signifi cance of the bacterial species Enterococcus in human life. 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