pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.17238/PmJ1609-1175.2018.4.41-45pmj-281Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHESИммунные комплексы и их роль в активации иммунитета при ВИЧ-инфекцииImmune complexes and their role in activation of immunity in HIV-infectionКоролевскаяЛ. Б.KorolevskayaL. B.bioqueen@mail.ruСайдаковаЕ. В.SaydakovaE. V.noemail@neicon.ruШмагельК. В.ShmagelK. V.noemail@neicon.ruШмагельН. Г.ShmagelN. G.noemail@neicon.ruПермский федеральный исследовательский центр УрО РАНРоссияPerm Scientific Centre of the Ural Branch of the Russian Academy of SciencesRussian FederationПермский федеральный исследовательский центр УрО РАН; Пермский краевой центр по профилактике и борьбе со СПИД и инфекционными заболеваниямиРоссияPerm Scientific Centre of the Ural Branch of the Russian Academy of Sciences; AIDS Prevention CentreRussian Federation201828122018044144Copyright © Королевская Л.Б., Сайдакова Е.В., Шмагель К.В., Шмагель Н.Г., 20182018Королевская Л.Б., Сайдакова Е.В., Шмагель К.В., Шмагель Н.Г.Korolevskaya L.B., Saydakova E.V., Shmagel K.V., Shmagel N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/281

У 30 ВИЧ-инфицированных пациентов определено содержание циркулирующих иммунных комплексов (ЦИК) и относительное количество активированных Т-лимфоцитов. Установлены прямые корреляционные связи между концентрацией ЦИК и активацией Т-клеток. Исследована роль иммунных комплексов, содержащих антигены ВИЧ и противовирусные антитела, в активации клеток врожденного иммунитета. Выявлено, что стимуляция мононуклеаров неифицирован-ных доноров такими иммунными агрегатами приводит к усилению генерации кислорода и значительному увеличению относительного количества СD14+-клеток, синтезирующих интерлейкин-6. По-видимому, иммунные комплексы могут считаться еще одним из факторов активации иммунитета при ВИЧ-инфекции.

Objective. Immune activation is the main predictor of the progression of infection caused by the human immunodeficiency virus (HIV). The reasons remain incomprehensible and, probably, can be multifactorial. We suggest that immune complexes are also capable of stimulating immunocompetent cells. Methods. We examined 30 HIV-infected patients who had concentrations of circulating immune complexes and the relative amount of activated T-lymphocytes. In vitro interaction of mononuclear cells of peripheral blood of uninfected donors with immune complexes containing HIV-antigens and antiviral antibodies. Results. It was found that the concentration of circulating immune complexes is directly related to the activation of T-lymphocytes. It has been shown that the interaction of mononuclear cells of healthy donors with immune complexes leads to a significant increase in the proportion of CD14+ monocytes producing interleukin-6 and to enhance the production of reactive oxygen species. Conclusions. Immune complexes containing HIV-antigens and antiviral antibodies are able to activate immunocompetent cells. Such complexes may be another factor in the activation of immunity in HIV-infection.

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The authors declare that there are no conflicts of interest present.