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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34215/1609-1175-2024-4-97-100</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-2837</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЯ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICE OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Дебют острого лимфобластного лейкоза под маской ювенильного идиопатического артрита</article-title><trans-title-group xml:lang="en"><trans-title>The debut of acute lymphoblastic leukemia under the guise of juvenile idiopathic arthritis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапина</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapina</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Волгоград</p></bio><bio xml:lang="en"><p>Volgograd</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белан</surname><given-names>Э. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Belan</surname><given-names>E. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Волгоград</p></bio><bio xml:lang="en"><p>Volgograd</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5521-7915</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чуева</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chueva</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Александровна Чуева, канд. мед. наук, доцент</p><p>кафедра иммунологии и аллергологии</p><p>400131;  пл. Павших Борцов, 1; Волгоград</p><p>тел.: +7 (927) 502-32-78</p></bio><bio xml:lang="en"><p>Maria A. Chueva, Cand. Sci. (Med.),, Associate Professor</p><p>Department of Immunology and Allergology</p><p>400131; 1 pl. Pavshih Borcov; Volgograd</p><p>phone: +7 (927) 502-32-78</p></bio><email xlink:type="simple">chuevamaria2008@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Волгоградский государственный медицинский университет; Детская клиническая больница № 8</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University; Children's Clinical Hospital No. 8</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Волгоградский государственный медицинский университет; Консультативно-диагностическая поликлиника № 2</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University; Consultative and Diagnostic Polyclinic No. 2</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>16</day><month>02</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>97</fpage><lpage>100</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лапина В.А., Белан Э.Б., Чуева М.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Лапина В.А., Белан Э.Б., Чуева М.А.</copyright-holder><copyright-holder xml:lang="en">Lapina V.A., Belan E.B., Chueva M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/2837">https://www.tmj-vgmu.ru/jour/article/view/2837</self-uri><abstract><p>   Костно-суставной синдром наблюдается у каждого третьего пациента с острым лимфобластным лейкозом. В некоторых случаях артралгии и артрит являются первым и единственным проявлением заболевания. Это затрудняет диагностический поиск и ведет к запоздалой постановке правильного диагноза. Представлен клинический случай дебюта острого лейкоза у ребенка с поражением костно-суставной системы. Развитие суставного синдрома при остром лимфобластном лейкозе актуализирует внимательное изучение анамнеза, клинических и лабораторных данных пациентов с предполагаемым диагнозом ювенильного идиопатического артрита.</p></abstract><trans-abstract xml:lang="en"><p>   The bone and joint syndrome is observed in one out of every three patients with acute lymphoblastic leukemia. In some cases, arthralgia and arthritis comprise the first and only manifestations of the disease. This complicates the diagnostic process and leads to a late diagnosis. The study presents a clinical case of the onset of acute leukemia in a child with bone and joint involvement. The development of joint syndrome in acute lymphoblastic leukemia highlights the necessity for careful examination of the medical history, clinical findings, and laboratory data in patients with a suspected diagnosis of juvenile idiopathic arthritis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый лейкоз</kwd><kwd>ювенильный идиопатический артрит</kwd><kwd>дифференциальная диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute leukemia</kwd><kwd>juvenile idiopathic arthritis</kwd><kwd>differential diagnosis</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Авторы заявляют о финансировании проведенного исследования из собственных средств</funding-statement><funding-statement xml:lang="en">The authors declare funding for the study from their own funds.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Tafaghodi F, Aghighi Y, Rokni Yazdi H, Shakiba M, Adibi A. 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