pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMU10.34215/1609-1175-2025-2-18-23pmj-2921Research ArticleОБЗОРЫREVIEWSХлорофилл и его дериваты в практической медицинеChlorophyll and its derivatives in practical medicinehttps://orcid.org/0000-0002-6206-200XКолдаевВ. М.KoldaevV. M.

Колдаев Владимир Михайлович – д-р биол. наук, профессор, ведущий научный сотрудник лаборатории лекарственных растений

690022, г. Владивосток, проспект 100-летия Владивостока, 159

Vladimir M. Koldaev, Dr. Sci. (Biol), Prof., Leading researcher, laboratory of medicinal plants

59 Avenue of 100-years Vladivostok, Vladivostok, 690022

kolvm42@rambler.ruКропотовА. В.KropotovA. V.Федеральный научный центр биоразнообразия наземной биоты Восточной Азии Дальневосточного отделения Российской академии наукРоссияFederal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of SciencesRussian FederationТихоокеанский государственный медицинский университетРоссияPacific State Medical UniversityRussian Federation202511082025021823Copyright © Колдаев В.М., Кропотов А.В., 20252025Колдаев В.М., Кропотов А.В.Koldaev V.M., Kropotov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/2921

Хлорофиллы – пигменты зеленых растений с антиоксидантной активностью – снижают риски хронических заболеваний. В обзоре суммированы данные о лечебно-профилактических эффектах хлорофиллов. Обогащенная хлорофиллами диета оказывает широкий спектр противоракового действия. Хлорофиллы защищают от окислительных повреждений дофаминэргические нейроны головного мозга и снижают выраженность нейродегенеративных расстройств при болезнях Альцгеймера и Паркинсона. Хлорофиллы индуцируют апоптоз адипоцитов и могут использоваться как средства профилактики развития ожирения. Однако метаболические пути хлорофиллов при употреблении с пищей и переваривании в желудочно-кишечном тракте изучены недостаточно. Хлорофиллы малоустойчивы и подвергаются деградации при переработке и хранении растительного сырья. В будущих исследованиях необходимы сопоставления терапевтических эффективностей хлорофиллов и соответствующих лекарственных препаратов в клинических условиях

Chlorophylls are pigments of green plants with antioxidant activity that reduce the risk of chronic diseases. The review summarizes data on the therapeutic and preventive effects of chlorophylls. A chlorophyll-enriched diet demonstrates a broad spectrum of anticancer activity. Chlorophylls protect dopaminergic neurons of the brain from oxidative damage and reduce the severity of neurodegenerative disorders in Alzheimer's and Parkinson's diseases. They also induce apoptosis in adipocytes and may serve as preventive agents against obesity. However, the metabolic pathways of chlorophylls when consumed with food and digested in the gastrointestinal tract remain insufficiently studied. Chlorophylls are relatively unstable and undergo degradation during the processing and storage of plant materials. Future research should focus on comparing the therapeutic efficacy of chlorophylls and corresponding pharmaceutical drugs under clinical conditions.

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The authors declare that there are no conflicts of interest present.