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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17238/PmJ1609-1175.2019.1.5-12</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-295</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EDITORIALS</subject></subj-group></article-categories><title-group><article-title>Дискуссионные вопросы терапии хронической обструктивной болезни легких (материалы совета экспертов ДФО от 13.06.2018 г., Владивосток)</article-title><trans-title-group xml:lang="en"><trans-title>Argumentative issues of chronic obstructive pulmonary disease (materials of panel of experts, Far Eastern Federal District from 06/13/2018, Vladivostok)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Невзорова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nevzorova</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авдеев</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Avdeev</surname><given-names>S. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондрашова</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kondrashova</surname><given-names>N. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шуматов</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Shumatov</surname><given-names>V. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куделя</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudelya</surname><given-names>L. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суханова</surname><given-names>Г. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sukhanova</surname><given-names>G. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киняйкин</surname><given-names>М. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Kinyaykin</surname><given-names>M. F.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumova</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудрявцева</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudryavtseva</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хижняк</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Khizhnyak</surname><given-names>Yu. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мусатов</surname><given-names>И. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Musatov</surname><given-names>I. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Государственная Новосибирская областная клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Novosibirsk Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Владивостокский клинико-диагностический центр</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vladivostok Clinical and Diagnostic Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Городская поликлиника № 4 Южно-Сахалинска</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yuzhno-Sakhalinsk City Outpatient Clinic No. 4</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Спасская городская поликлиника</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Spassk City Outpatient Clinic</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>28</day><month>03</month><year>2019</year></pub-date><volume>0</volume><issue>1</issue><fpage>5</fpage><lpage>12</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Невзорова В.А., Авдеев С.Н., Кондрашова Н.М., Шуматов В.Б., Куделя Л.М., Суханова Г.И., Киняйкин М.Ф., Наумова И.В., Кудрявцева В.А., Хижняк Ю.Ю., Мусатов И.Б., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Невзорова В.А., Авдеев С.Н., Кондрашова Н.М., Шуматов В.Б., Куделя Л.М., Суханова Г.И., Киняйкин М.Ф., Наумова И.В., Кудрявцева В.А., Хижняк Ю.Ю., Мусатов И.Б.</copyright-holder><copyright-holder xml:lang="en">Nevzorova V.A., Avdeev S.N., Kondrashova N.M., Shumatov V.B., Kudelya L.M., Sukhanova G.I., Kinyaykin M.F., Naumova I.V., Kudryavtseva V.A., Khizhnyak Y.Y., Musatov I.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/295">https://www.tmj-vgmu.ru/jour/article/view/295</self-uri><abstract><p>В статье отражены дискуссионные вопросы лечения хронической обструктивной болезни легких (ХОБЛ), представляющей глобальную проблему современной медицины. По данным ВОЗ, ХОБЛ - третья лидирующая причина смерти в мире. Ежегодно от этого заболевания умирает около 2,8 млн человек, и за последние двадцать лет данная статистика не изменилась. В развитых странах наибольшие затраты для систем здравоохранения в лечении заболеваний дыхательных путей связаны с обострениями ХОБЛ, которые негативно влияют на течение этого заболевания, вызывая необратимое прогрессирующее снижение функции легких, ухудшение качества жизни, увеличивают частоту повторных госпитализаций и смертность. Таким образом, предотвращение обострений ХОБЛ имеет социальную и экономическую значимость и должно стать первостепенной задачей при лечении данного заболевания.</p></abstract><trans-abstract xml:lang="en"><p>The article represents argumentative issues of Chronic Obstructive Pulmonary Disease (COPD) treatment which is a global problem of modern medicine. According to WHO data COPD is the third leading cause of death worldwide, annually about 2.8 million people die because of this disease, and over 20 years this statistics never changed. In developed countries the highest costs for health systems in the treatment of respiratory diseases are associated with COPD which affect the course of this disease causing an irreversible progressive decline in lung function, deteriorating quality of life, increasing the frequency of readmissions and mortality. Thus, the prevention of exacerbations of COPD is of social and economic importance and should be a priority in the treatment of this disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>обострение хронической обструктивной болезни легких</kwd><kwd>противовоспалительная терапия</kwd><kwd>экстрамелкодисперсные ингаляционные глюкокортикостероиды</kwd></kwd-group><kwd-group xml:lang="en"><kwd>exacerbations of chronic obstructive pulmonary disease</kwd><kwd>anti-inflammatory therapy</kwd><kwd>extra-micronisedinhaled glucocorticosteroids</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">ВОЗ. Информационный листок № 297. 2018. URL: http:// www.who.int/mediacentre/factsheets/fs297/en/ (дата доступа: 03.11.2018).</mixed-citation><mixed-citation xml:lang="en">ВОЗ. Информационный листок № 297. 2018. 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