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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34215/1609-1175-2026-2-82-85</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-3148</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЯ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICE OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Прогнозирование обструктивного поражения коронарных артерий у пациента с острым коронарным синдромом без подъема сегмента ST (клинический случай)</article-title><trans-title-group xml:lang="en"><trans-title>Prediction of obstructive coronary artery disease in patients with non-ST elevation acute coronary syndrome (a clinical case)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3545-3862</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Циванюк</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsivanyuk</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Циванюк Михаил Михайлович – к.м.н., старший научный сотрудник лаборатории анализа больших данных в здравоохранении и медицине Дальневосточного ФУ; заведующий отделением рентгенохирургических методов диагностики и лечения Владивостокской клинической больницы № 1</p><p>690922, Владивосток, о. Русский, п. Аякс, 10; 690078, Владивосток, ул. Садовая, 22; тел.: +7 (914) 791-60-63</p></bio><bio xml:lang="en"><p>Mikhail M. Tsivanyuk - Cand. Sci. (Med.), Senior Researcher at the Laboratory for Big Data Analysis in Healthcare and Medicine, Far EFU, Head of the Department of Department of Interventional Radiology, Vladivostok Clinical Hospital No. 1.</p><p>10 Ajax Bay, Russky Island, Vladivostok, 690922; 22 Sadovaya str., Vladivostok, 690078; tel.: +7 (914) 791-60-63</p></bio><email xlink:type="simple">m_tsivanyuk@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гельцер</surname><given-names>Б. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Geltser</surname><given-names>B. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Владивостокская клиническая больница № 1; Дальневосточный федеральный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vladivostok Clinical Hospital No 1; Far Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Дальневосточный федеральный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Vladivostok Clinical Hospital No 1</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>19</day><month>07</month><year>2026</year></pub-date><volume>0</volume><issue>2</issue><fpage>82</fpage><lpage>85</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Циванюк М.М., Гельцер Б.И., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Циванюк М.М., Гельцер Б.И.</copyright-holder><copyright-holder xml:lang="en">Tsivanyuk M.M., Geltser B.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/3148">https://www.tmj-vgmu.ru/jour/article/view/3148</self-uri><abstract><p>Актуальные клинические подходы подчеркивают значимость ранней стратификации риска у пациентов с острым коронарным синдромом без подъема сегмента ST. В то же время определение оптимальной стратегии ведения пациентов с невысоким риском неблагоприятных исходов остается сложной клинической задачей. Разработанная нами модель на основе стохастического градиентного бустинга обеспечивает точную оценку вероятности обструктивного поражения коронарных артерий в первые часы госпитализации, поэтапно интегрируя данные первичного осмотра, а также исследований через 1 и 3 часа. В работе представлен клинический случай, иллюстрирующий ее практическое применение.</p></abstract><trans-abstract xml:lang="en"><p>Current clinical guidelines emphasize the need for early risk stratification in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Meanwhile, the choice between invasive and conservative strategies for patients at low risk for adverse outcomes remains challenging. Our predictive model, developed using stochastic gradient boosting, highly accurately assesses the probability of obstructive coronary artery disease in the first hours of hospitalization. Data from three time points are sequentially integrated: the initial examination, one hour later (complete blood count), and three hours later (biochemistry and echocardiography). This article presents a clinical case that illustrates the practical application of the model.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>прогностические модели</kwd><kwd>стохастический градиентный бустинг</kwd><kwd>коронарные артерии</kwd><kwd>острый коронарный синдром</kwd><kwd>стратификация риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>predictive models</kwd><kwd>stochastic gradient boosting</kwd><kwd>coronary arteries</kwd><kwd>acute coronary syndrome</kwd><kwd>risk stratification</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">работа выполнена при финансовой поддержке проекта FZNS-2026-0014 Госзадания ДВФУ</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Khera R, Haimovich J, Hurley NC, McNamara R, Spertus JA, Desai N, et al. Use of Machine Learning Models to Predict Death After Acute Myocardial Infarction. JAMA Cardiol. 2021;6(6):633–641. doi: 10.1001/jamacardio.2021.0122</mixed-citation><mixed-citation xml:lang="en">Khera R, Haimovich J, Hurley NC, McNamara R, Spertus JA, Desai N, et al. Use of Machine Learning Models to Predict Death After Acute Myocardial Infarction. JAMA Cardiol. 2021;6(6):633–641. doi: 10.1001/jamacardio.2021.0122</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Badertscher P, Boeddinghaus J, Twerenbold R, Nestelberger T, Wildi K, Wussler D, et al. Direct Comparison of the 0/1h and 0/3h Algorithms for Early Rule-Out of Acute Myocardial Infarction. Circulation. 2018;137(23):2536–2538. doi: 10.1161/CIRCULATIONAHA.118.034260</mixed-citation><mixed-citation xml:lang="en">Badertscher P, Boeddinghaus J, Twerenbold R, Nestelberger T, Wildi K, Wussler D, et al. Direct Comparison of the 0/1h and 0/3h Algorithms for Early Rule-Out of Acute Myocardial Infarction. Circulation. 2018;137(23):2536–2538. doi: 10.1161/CIRCULATIONAHA.118.034260</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mueller C, Giannitsis E, Christ M, Ordóñez-Llanos J, deFilippi C, McCord J, et al. Multicenter Evaluation of a 0-Hour/1-Hour Algorithm in the Diagnosis of Myocardial Infarction With High-Sensitivity Cardiac Troponin T. Annals of emergency medicine. 2016;68(1):76-87.e4. doi: 10.1016/j.annemergmed.2015.11.013</mixed-citation><mixed-citation xml:lang="en">Mueller C, Giannitsis E, Christ M, Ordóñez-Llanos J, deFilippi C, McCord J, et al. Multicenter Evaluation of a 0-Hour/1-Hour Algorithm in the Diagnosis of Myocardial Infarction With HighSensitivity Cardiac Troponin T. Annals of emergency medicine. 2016;68(1):76-87.e4. doi: 10.1016/j.annemergmed.2015.11.013</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Foy AJ, Liu G, Davidson WR Jr, Sciamanna C, Leslie DL. Comparative effectiveness of diagnostic testing strategies in emergency department patients with chest pain: an analysis of downstream testing, interventions, and outcomes. JAMA internal medicine. 2015;175(3):428–436. doi: 10.1001/jamainternmed.2014.7657</mixed-citation><mixed-citation xml:lang="en">Foy AJ, Liu G, Davidson WR Jr, Sciamanna C, Leslie DL. Comparative effectiveness of diagnostic testing strategies in emergency department patients with chest pain: an analysis of downstream testing, interventions, and outcomes. JAMA internal medicine. 2015;175(3):428–436. doi: 10.1001/jamainternmed.2014.7657</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Geltser BI, Tsivanyuk MM, Shakhgeldyan KI, Emtseva ED, Vishnevskiy AA. Cardiometabolic risk factors in predicting obstructive coronary artery disease in patients with non-ST-segment elevation acute coronary syndrome. Russian Journal of Cardiology. 2021;26(11):4494. (In Russ.). doi: 10.15829/1560-4071-2021-4494</mixed-citation><mixed-citation xml:lang="en">Geltser BI, Tsivanyuk MM, Shakhgeldyan KI, Emtseva ED, Vishnevskiy AA. Cardiometabolic risk factors in predicting obstructive coronary artery disease in patients with non-ST-segment elevation acute coronary syndrome. Russian Journal of Cardiology. 2021;26(11):4494. (In Russ.). doi: 10.15829/1560-4071-2021-4494</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann U, Truong QA, Schoenfeld DA, Chou ET, Woodard PK, Nagurney JT, et al. Coronary CT angiography versus standard evaluation in acute chest pain. The New England journal of medicine. 2012;26;367(4):299–308. doi: 10.1056/NEJMoa1201161</mixed-citation><mixed-citation xml:lang="en">Hoffmann U, Truong QA, Schoenfeld DA, Chou ET, Woodard PK, Nagurney JT, et al. Coronary CT angiography versus standard evaluation in acute chest pain. The New England journal of medicine. 2012;26;367(4):299–308. doi: 10.1056/NEJMoa1201161</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, et al. The HEART Pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Circulation. Cardiovascular quality and outcomes. 2015;8(2):195–203. doi: 10.1161/CIRCOUTCOMES.114.001384</mixed-citation><mixed-citation xml:lang="en">Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, et al. The HEART Pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Circulation. Cardiovascular quality and outcomes. 2015;8(2):195–203. doi: 10.1161/CIRCOUTCOMES.114.001384</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tsivanyuk MM, Shakhgeldyan KI, Markov MA, Shirobokov VG, Geltser BI. Machine Learning Efficiency in Predicting Obstructive Coronary Artery Disease in Patients with Non-ST Elevation Acute Coronary Syndrome in the First Hours of Admission. Sovremennye tekhnologii v meditsine. 2025;17(3):50–60. (In Russ.) doi: 10.17691/stm2025.17.3.05</mixed-citation><mixed-citation xml:lang="en">Tsivanyuk MM, Shakhgeldyan KI, Markov MA, Shirobokov VG, Geltser BI. Machine Learning Efficiency in Predicting Obstructive Coronary Artery Disease in Patients with Non-ST Elevation Acute Coronary Syndrome in the First Hours of Admission. Sovremennye tekhnologii v meditsine. 2025;17(3):50–60. (In Russ.) doi: 10.17691/stm2025.17.3.05</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tsivanyuk MM, Geltser BI, Shakhgeldyan KI, Vishnevskiy AA, Shekunova OI. Parameters of complete blood count, lipid profile and their ratios in predicting obstructive coronary artery disease in patients with non-ST elevation acute coronary syndrome. Russian Journal of Cardiology. 2022;27(8):5079. (In Russ.). doi: 10.15829/1560-4071-2022-5079</mixed-citation><mixed-citation xml:lang="en">Tsivanyuk MM, Geltser BI, Shakhgeldyan KI, Vishnevskiy AA, Shekunova OI. Parameters of complete blood count, lipid profile and their ratios in predicting obstructive coronary artery disease in patients with non-ST elevation acute coronary syndrome. Russian Journal of Cardiology. 2022;27(8):5079. (In Russ.). doi: 10.15829/1560-4071-2022-5079</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Fox KA, Dabbous OH, Goldberg RJ, Pieper KS, Eagle KA, Van de Werf F, et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). BMJ. 2006;333(7578):1091. doi: 10.1136/bmj.38985.646481.55</mixed-citation><mixed-citation xml:lang="en">Fox KA, Dabbous OH, Goldberg RJ, Pieper KS, Eagle KA, Van de Werf F, et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). BMJ. 2006;333(7578):1091. doi: 10.1136/bmj.38985.646481.55</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Antman EM, Cohen M, Bernink PJ, McCabe CH, Horacek T, Papuchis G, et al. The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making. JAMA. 2000;284(7):835–842. doi: 10.1001/jama.284.7.835</mixed-citation><mixed-citation xml:lang="en">Antman EM, Cohen M, Bernink PJ, McCabe CH, Horacek T, Papuchis G, et al. The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making. JAMA. 2000;284(7):835–842. doi: 10.1001/jama.284.7.835</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Beam AL, Kohane IS. Big Data and Machine Learning in Health Care. JAMA. 2018;319(13):1317–1318. doi: 10.1001/jama.2017.18391</mixed-citation><mixed-citation xml:lang="en">Beam AL, Kohane IS. Big Data and Machine Learning in Health Care. JAMA. 2018;319(13):1317–1318. doi: 10.1001/jama.2017.18391</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson KW, Torres Soto J, Glicksberg BS, Shameer K, Miotto R, Ali M, et al. Artificial Intelligence in Cardiology. JACC. 2018;71(23):2668–2679. doi: 10.1016/j.jacc.2018.03.521</mixed-citation><mixed-citation xml:lang="en">Johnson KW, Torres Soto J, Glicksberg BS, Shameer K, Miotto R, Ali M, et al. Artificial Intelligence in Cardiology. JACC. 2018;71(23):2668–2679. doi: 10.1016/j.jacc.2018.03.521</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Shameer K, Johnson KW, Glicksberg BS, Dudley JT, Sengupta PP. Machine learning in cardiovascular medicine: are we there yet? Heart. 2018;104(14):1156–64. doi: 10.1136/heartjnl-2017-311198</mixed-citation><mixed-citation xml:lang="en">Shameer K, Johnson KW, Glicksberg BS, Dudley JT, Sengupta PP. Machine learning in cardiovascular medicine: are we there yet? Heart. 2018;104(14):1156–64. doi: 10.1136/heartjnl-2017-311198</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Attia ZI, Kapa S, Lopez-Jimenez F, McKie PM, Ladewig DJ, Satam G, et al. Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram. Nature medicine. 2019;25(1):70–74. doi: 10.1038/s41591-018-0240-2</mixed-citation><mixed-citation xml:lang="en">Attia ZI, Kapa S, Lopez-Jimenez F, McKie PM, Ladewig DJ, Satam G, et al. Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram. Nature medicine. 2019;25(1):70–74. doi: 10.1038/s41591-018-0240-2</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
