pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-34Research ArticleОБЗОРЫREVIEWSСосудистая дисфункция и периадвентициальная жировая тканьVascular dysfunction and periadventitial adipose tissueЦветковД. ..TsvetkovD. ..noemail@neicon.ruСийартоИ. А.SzijârtoI. A.noemail@neicon.ruВангН. ..WangN. ..noemail@neicon.ruТаноЙ. И.TanoJ. -Y.noemail@neicon.ruГоллахМ. ..GollaschM. ..maik.gollasch@charite.deУниверситетский медицинский комплекс ШаритеРоссияCharite University Medicine BerlinRussian Federation201628062016023133Copyright © Цветков Д..., Сийарто И.А., Ванг Н..., Тано Й.И., Голлах М..., 20162016Цветков Д..., Сийарто И.А., Ванг Н..., Тано Й.И., Голлах М...Tsvetkov D..., Szijârto I.A., Wang N..., Tano J.-., Gollasch M...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/34

К настоящему времени расшифрованы основные механизмы регуляции сосудистого тонуса. Считается, в частности, что жировая ткань, окружающая сосуды, служит источником ADRF (adipocyte-derived relaxing factor). Важно отметить, что именно локальные паракринные расстройства могут стать причиной сосудистой дисфункции. Наиболее вероятным кандидатом на роль ADRF называют сероводород (H2S). На экспериментальных моделях ожирения, артериальной гипертонии и метаболического синдрома доказано наличие и других соединений, участвующих в периадвентициальной регуляции сосудистого тонуса посредством влияния на калиевые каналы клеточных мембран. Вазоактивные структуры жировых клеток или их рецепторы могут оказаться перспективными мишенями для разработки новых сердечно-сосудистых препаратов.

Over the last years, concerted efforts have helped to uncover and understand the basic mechanisms of periadventitial regulation of arterial tone by perivascular adipose tissue. Basically, perivascular adipose tissue serves as source for “Adipocyte-derived relaxing factor” (ADRF), an essential player in the control of vascular tone of visceral and other arteries. Importantly, its disturbed local, paracrine activity is able to cause vascular dysfunction. Hydrogen sulfide (H2S) is a putative candidate for ADRF, which has received increased attention. The importance of this and other candidates for periadventitial vasoregulation has been recently explored in rodent models of obesity, hypertension and metabolic syndrome. Pharmacological tools have been successfully used to clarify the role of potassium channels involved in these conditions. Vasoactive factors of adipocytes or their receptors could represent targets for the development of novel cardiovascular drugs.

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The authors declare that there are no conflicts of interest present.