<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title-group><journal-title xml:lang="ru">Тихоокеанский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Pacific Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1609-1175</issn><publisher><publisher-name>TGMU</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34215/1609-1175-2020-3-88-89</article-id><article-id custom-type="elpub" pub-id-type="custom">pmj-501</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТОДИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METHODS</subject></subj-group></article-categories><title-group><article-title>Дисперсный биокомпозит на основе волластонита/гидроксиаппатита: остеопластический потенциал с точки зрения рентгенологии</article-title><trans-title-group xml:lang="en"><trans-title>Dispersed biocomposite based on wollastonite/hydroxyapatite: Osteoplastic potential in terms of radiology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Апанасевич</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Apanasevich</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор Института хирургии,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>MD, PhD, professor, Institute of Surgery, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">oncolog222@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Папынов</surname><given-names>Е. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Papynov</surname><given-names>E. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток</p></bio><bio xml:lang="en"><p>Vladivostok</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5564-7579</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Афонин</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Afonin</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант Института хирургии,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>MD, postgraduate student, Institute of Surgery, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">igor23-45@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евдокимов</surname><given-names>И. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Evdokimov</surname><given-names>I. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант Школы биомедицины,</p><p>690922, г. Владивосток, бухта Аякс, 10</p></bio><bio xml:lang="en"><p>MD, postgraduate student, </p><p>10 Ajax Bay, Russky Island, Vladivostok, 690922</p></bio><email xlink:type="simple">evdokimov.ivan111@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шичалин</surname><given-names>О. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Shichalin</surname><given-names>O. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант,</p><p>690022, г. Владивосток, пр-т 100-летия Владивостока, 159</p></bio><bio xml:lang="en"><p>postgraduate student, </p><p>159 Stoletiya Vladivostoka Ave., Vladivostok, 690022</p></bio><email xlink:type="simple">oleg_shich@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанюгина</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanyugina</surname><given-names>A. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка лечебного факультета,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>student, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">stepanyugina@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панкратов</surname><given-names>Н. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Pankratov</surname><given-names>N. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студент лечебного факультета,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>student, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">razorrbox@gmail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коршунова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korshunova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, старший преподаватель кафедры фармакологии,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>MD, PhD, assistant, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">farmaoks@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Агафонова</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Agafonova</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. биол. наук, старший научный сотрудник лаборатории биоиспытаний и механизма действия биологически активных веществ,</p><p>690022, г. Владивосток, пр-т 100-летия Владивостока, 159/2</p></bio><bio xml:lang="en"><p>PhD, senior researcher, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, </p><p>159/2 Stoletiya Vladivostoka Ave., Vladivostok, 690022</p></bio><email xlink:type="simple">agafonova@piboc.dvo.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зиновьев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zinoviev</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, старший научный сотрудник центральной научно-исследовательской лаборатории,</p><p>690002, г. Владивосток, пр-т Острякова, 2</p></bio><bio xml:lang="en"><p>MD, PhD, senior researcher, </p><p>2 Ostryakova Ave., Vladivostok, 690002</p></bio><email xlink:type="simple">sinowev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гельцер</surname><given-names>Б. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Geltser</surname><given-names>B. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, член-корреспондент РАН, директор департамента клинической медицины Школы биомедицины,</p><p>690922, г. Владивосток, бухта Аякс, 10</p></bio><bio xml:lang="en"><p>MD, PhD, professor, director of the Clinical Medicine Department, </p><p>10 Ajax Bay, Russky Island, Vladivostok, 690922</p></bio><email xlink:type="simple">geltce.bi@dvfu.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тихоокеанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт химии ДВО РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Chemistry, Far Eastern Branch of Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Дальневосточный федеральный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Far Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Тихоокеанский институт биоорганической химии им. Г.Б. Елякова ДВО РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2020</year></pub-date><volume>0</volume><issue>3</issue><fpage>88</fpage><lpage>89</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Апанасевич В.И., Папынов Е.К., Афонин И.С., Евдокимов И.О., Шичалин О.О., Степанюгина А.С., Панкратов Н.Р., Коршунова О.В., Агафонова И.Г., Зиновьев С.В., Гельцер Б.И., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Апанасевич В.И., Папынов Е.К., Афонин И.С., Евдокимов И.О., Шичалин О.О., Степанюгина А.С., Панкратов Н.Р., Коршунова О.В., Агафонова И.Г., Зиновьев С.В., Гельцер Б.И.</copyright-holder><copyright-holder xml:lang="en">Apanasevich V.I., Papynov E.K., Afonin I.S., Evdokimov I.O., Shichalin O.O., Stepanyugina A.K., Pankratov N.R., Korshunova O.V., Agafonova I.G., Zinoviev S.V., Geltser B.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tmj-vgmu.ru/jour/article/view/501">https://www.tmj-vgmu.ru/jour/article/view/501</self-uri><abstract><sec><title>Цель</title><p>Цель: оценка регенерации костной ткани альвеолярного отростка при имплантации биокомпозита на основе волластонита/гидроксиаппатита (ГАП) в  эксперименте.</p></sec><sec><title>Материал и  методы</title><p>Материал и  методы. Четырем кроликам-самкам под общим наркозом и местной анестезией выполнена экстракция нижних левых резцов с последующей аугментацией биокомпозитом. Результаты оценивались посредством конусно-лучевой компьютерной томографии.</p></sec><sec><title>Результаты</title><p>Результаты. В первые сутки средняя плотность костной структуры альвеолярной лунки равнялась 37 HU, на 60-е она достигала 1090 HU. Контур альвеолярной лунки не прослеживался уже на 35-е сутки. Признаков остеолиза не наблюдалось.</p></sec><sec><title>Заключение</title><p>Заключение. Результат эксперимента подтверждает участие биокомпозита на основе CaSiO₃/ГАП в регенерации костной ткани, о чем свидетельствует динамика увеличения объема кости в области альвеол удаленных зубов нижней челюсти подопытных животных. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: assessment of the bone tissue regeneration of alveolar ridge during implantation of biocomposite based on wollastonite/hydroxyapatite (HA) in the experiment.</p></sec><sec><title>Methods</title><p>Methods: Four female rabbits were performed the extraction of lower left incisors under the general and local anesthesia followed by the augmentation with biocomposite. The results were assessed with cone beam computed tomography.</p></sec><sec><title>Results</title><p>Results: On the first day, the average density of bone structure of the alveolar socket was 37 HU; on the 60th day, it reached 1090 HU. The contour of the alveolar socket was not already visible on the 35th day. There were no signs of the osteolysis.</p></sec><sec><title>Conclusions</title><p>Conclusions: The experiment result confirms the the participation of a CaSiO3/HA biocomposite in bone tissue regeneration, as evidenced by the dynamics of the increase in bone volume in the alveoli of the removed teeth of the lower jaw of experimental animals. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>силикат кальция</kwd><kwd>гидроксиаппатит</kwd><kwd>регенерация кости</kwd><kwd>эксперимент</kwd></kwd-group><kwd-group xml:lang="en"><kwd>calcium silicate</kwd><kwd>hydroxyapatite</kwd><kwd>bone regeneration</kwd><kwd>experiment</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при финансовой поддержке Российского научного фонда (грант № 18-73-10107).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Juhasz JA, Best SM. Bioactive ceramics: Processing, structures and properties. J Mater Sci. 2012;47:610–24.</mixed-citation><mixed-citation xml:lang="en">Juhasz JA, Best SM. Bioactive ceramics: Processing, structures and properties. J Mater Sci. 2012;47:610–24.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Fini M, Giavaresi G, Torricelli P, Borsari V, Giardino R, Nicolini A, Carpi A. Osteoporosis and biomaterial osteointegration. Biomed Pharmacother. 2004;58(9):487–93.</mixed-citation><mixed-citation xml:lang="en">Fini M, Giavaresi G, Torricelli P, Borsari V, Giardino R, Nicolini A, Carpi A. Osteoporosis and biomaterial osteointegration. Biomed Pharmacother. 2004;58(9):487–93.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Stevens MM. Biomaterials for bone tissue engineering. Mater Today. 2008;11(5):18–25.</mixed-citation><mixed-citation xml:lang="en">Stevens MM. Biomaterials for bone tissue engineering. Mater Today. 2008;11(5):18–25.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Dubok VA. Bioceramics – yesterday, today, tomorrow, powder metall. Met Ceram. 2001;39:381–94.</mixed-citation><mixed-citation xml:lang="en">Dubok VA. Bioceramics – yesterday, today, tomorrow, powder metall. Met Ceram. 2001;39:381–94.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Papynov EK, Shichalin OO, Medkov MA, Grishchenko DN, Portnyagin AS, Merkulov EB, et al. ZrO2-phosphates porous ceramic obtained via sps-rs “in situ” technique: Bacteria test assessment. Ceram Int. 2019;45(11):13838–46.</mixed-citation><mixed-citation xml:lang="en">Papynov EK, Shichalin OO, Medkov MA, Grishchenko DN, Portnyagin AS, Merkulov EB, et al. ZrO2-phosphates porous ceramic obtained via sps-rs “in situ” technique: Bacteria test assessment. Ceram Int. 2019;45(11):13838–46.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">World Medical Association Declaration of Helsinki. JAMA. 2013;310(20):2191–4. doi:10.1001/jama.2013.281053.</mixed-citation><mixed-citation xml:lang="en">World Medical Association Declaration of Helsinki. JAMA. 2013;310(20):2191–4. doi:10.1001/jama.2013.281053.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
