pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-507Research ArticleОБЗОРЫREVIEWSЛечение опухолей головного мозга методом бор-нейтронзахватной терапии: трудности и современные решенияTreatment of brain tumors by the method of the boron neutron capturing therapy: challenges and modern solutionsЯруллинаА. И.YarullinaA. I.yarullinaai@yahoo.comКаныгинВ. В.KanyginV. V.noemail@neicon.ruКичигинА. И.KichiginA. I.noemail@neicon.ruЖдановаМ. Г.ZhdanovaM. G.noemail@neicon.ruМухамадияровР. А.MukhamadiyarovR. A.noemail@neicon.ruТаскаевС. Ю.TaskaevS. Ju.noemail@neicon.ruИнститут ядерной физики им. Г.И. Будкеpа; Иркутский государственный медицинский университетРоссияBudker Institute of Nuclear Physics; Irkutsk State Medical UniversityRussian FederationИнститут ядерной физики им. Г.И. Будкеpа; Новосибирский государственный медицинский университет; Дорожная клиническая больница на ст. Новосибирск-ГлавныйРоссияBudker Institute of Nuclear Physics; Novosibirsk State Medical University; Railway Clinical Hospital on the station NovosibirskRussian FederationИнститут ядерной физики им. Г.И. Будкеpа; Дорожная клиническая больница на ст. Новосибирск-ГлавныйРоссияBudker Institute of Nuclear Physics; Railway Clinical Hospital on the station NovosibirskRussian FederationИнститут ядерной физики им. Г.И. БудкеpаРоссияBudker Institute of Nuclear PhysicsRussian FederationНИИ комплексных проблем сердечно-сосудистых заболеванийРоссияScientific Research Institute of Complex Problems of Cardiovascular DiseasesRussian FederationИнститут ядерной физики им. Г.И. Будкеpа; Новосибирский государственный университетРоссияBudker Institute of Nuclear Physics; Novosibirsk State UniversityRussian Federation20152812201504410Copyright © Яруллина А.И., Каныгин В.В., Кичигин А.И., Жданова М.Г., Мухамадияров Р.А., Таскаев С.Ю., 20152015Яруллина А.И., Каныгин В.В., Кичигин А.И., Жданова М.Г., Мухамадияров Р.А., Таскаев С.Ю.Yarullina A.I., Kanygin V.V., Kichigin A.I., Zhdanova M.G., Mukhamadiyarov R.A., Taskaev S.J.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/507

Статья знакомит с методом бор-нейтронзахватной терапии (БНЗТ) и возможностями ее клинического применения для лечения опухолей головного мозга. Приводятся анализ и обзор данных литературы о БНЗТ, а также статистика выживаемости пациентов. Дается сравнительная характеристика различных источников нейтронов, используемых для этого метода лечения. Рассматривается решение двух проблем клинического внедрения БНЗТ: создание автономного источника эпитепловых нейтронов и избирательной доставки бор-содержащих препаратов к центральной нервной системе. Анализ решения данных проблем дополняется результатами разработок и экспериментальными данными лаборатории БНЗТ Института ядерной физики СО РАН.

The article introduces the method of boron neutron capturing therapy (BNCT) and its potential clinical application for treatment of malignant brain tumors. The analysis and literature review of the use of BNCT in the world, citing statistics on the survival rate of patients with brain tumor after a session of BNCT. Comparative characteristics of various neutron sources used for BNCT in the world. A review of pharmacological agents used in BNCT as a delivery agent 10B. Based on the review of the literature produced outlining the recognized problems of the method. We consider the two challenges for clinical implementation of BNCT - create an independent source of epithermal neutrons and selective delivery of boron-containing drugs to the central nervous system. Analysis of the solution of these difficulties is complemented by the results of development and experimental data of the laboratory of BNCT of Budker Institute of Nuclear Physics.

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The authors declare that there are no conflicts of interest present.