pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-510Research ArticleОБЗОРЫREVIEWSРоль матричных металлопротеиназ и провоспалительных цитокинов в регенерации межпозвонкового дискаRole of matrix matalloproteinases and proinflamatory cytokines in regeneration of the intervertebral discБардоноваЛ. А.BardonovaL. A.noemail@neicon.ruБелыхЕ. Г.BelykhE. G.noemail@neicon.ruСтепановИ. А.StepanovI. A.noemail@neicon.ruБывальцевВ. А.Byval’TsevV. A.byval75vadim@yandex.ruИркутский государственный медицинский университетРоссияIrkutsk State Medical UniversityRussian FederationИркутский научный центр хирургии и травматологииРоссияIrkutsk Scientific Center of Surgery and TraumatologyRussian FederationИркутский государственный медицинский университет; Иркутский научный центр хирургии и травматологии; Дорожная клиническая больница на ст. Иркутск-ПассажирскийРоссия10 Botkina St. Irkutsk 664082 Russian FederationRussian Federation201528122015042125Copyright © Бардонова Л.А., Белых Е.Г., Степанов И.А., Бывальцев В.А., 20152015Бардонова Л.А., Белых Е.Г., Степанов И.А., Бывальцев В.А.Bardonova L.A., Belykh E.G., Stepanov I.A., Byval’Tsev V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/510

В настоящее время дегенеративные процессы межпозвонкового диска - предельно актуальная проблема современной медицины. Наиболее частым проявлением дегенерации межпозвонкового диска считается боль спине, которая сопряжена с ранней утратой трудоспособности пациентов. Гибель клеток межпозвонкового диска, уменьшение синтеза белков и деградация основного вещества межклеточного матрикса диска за счет активации матриксных металлопротеиназ являются одним из важных звеньев патогенеза дегенерирующего диска, происходящего при участии провоспалительных цитокинов. Современная терапия дегенеративных процессов межпозвонкового диска направлена не только на устранение болевого синдрома, но и на восстановление функций диска с помощью различных методов биологического воздействия. Для активации регенераторных процессов межпозвонкового диска разрабатываются различные подходы, включающие инъекции белков-активаторов различных типов клеток или клеточных популяций и стимуляторы секреции внеклеточного матрикса, а также методы генной инженерии. Именно молекулярные методы биологической терапии дегенерации межпозвонкового диска представляются наиболее перспективными и в будущем могут быть транслированы в клиническую практику.

Intervertebral disc degeneration is an urgent problem of modern medicine. The most frequent symptom associated with intervertebral disc degeneration is back pain with leads to early disability of patients. Cell death, reduction of synthesis of extracellular matrix proteins and destruction of the basic substance due to activation of matrix metalloproteinases are one of the main chain link of intervertebral degeneration which is progressed with the contribution from the proinflammatory cytokines. Modern therapy of intervertebral disc degeneration is aimed not only in reducing the pain, but also in restoration of the functions of the disc through a variety of methods of biological therapy. Different approaches currently under development are targeted at activation of the regenerative processes in the intervertebral disc using injections of bioactive proteins, different types of cells or cell populations, and the stimulators of extracellular matrix production, as well as methods of gene engineering. These methods of biological treatment of degenerated intervertebral discs are promising and could be translated into clinical practice.

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