pmjТихоокеанский медицинский журналPacific Medical Journal1609-1175TGMUpmj-536Research ArticleОБЗОРЫREVIEWSФармакологические свойства, экспериментальные исследования и клиническое применение тафлупростаThe pharmacological properties, experimental research and clinical application of tafluprostПетровС. Ю.PetrovS. Yu.post@glaucomajournal.ruСафоноваД. М.SafonovaD. M.noemail@neicon.ruНИИ глазных болезнейРоссияScientific Research Institute of Eye DiseasesRussian Federation201528092015031113Copyright © Петров С.Ю., Сафонова Д.М., 20152015Петров С.Ю., Сафонова Д.М.Petrov S.Y., Safonova D.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tmj-vgmu.ru/jour/article/view/536

В обзоре представлена информация о тафлупросте -первом коммерчески доступном аналоге простагландина без консерванта в форме юнит-дозы. Описана фармакодинамика препарата, дана характеристика экспериментальных доклинических исследований, а также первых трех фаз клинических испытаний препарата. Показан высокий гипотензивный эффект тафлупроста при местном применении у пациентов с офтальмогипертензией и первичной открытоугольной глаукомой. Проведен анализ пострегистрационных исследований сравнительной эффективности и переносимости. Дана оценка перспектив применения нового препарата.

Pharmacodynamics of tafluprost, the first commercially available preservative-free unit-dose prostaglandin analogue, is analyzed in the article. Characteristic of the experimental pre-clinical studies, as well as the first three phases of tafluprost clinical trials are presented. A strong IOP-lowering effect of a once a day local administration of tafluprost in the patients with ocular hypertension and primary open-angle glaucoma is described. The review also analyzes post-approval studies of the comparative efficacy and tolerability of tafluprost and assesses the prospects of the new drug.

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The authors declare that there are no conflicts of interest present.